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ProteomicsProteomics of serotonergic autoregulation
Serotonin regulates its own production, degradation and release in the Raphe nuclei of the brain mainly by modifying the level and activity of autoreceptors on serotonin-producing neurons, such as 5-HT1A and 5-HT1B. This autoregulation is probably the reason for the delayed response of patients with...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD055579 | Pride
Serotonin Serotonin transporter Brain Tryptophan hydroxylase Autoregulation Mouse 
ProteomicsUSP15 deubiquitinase safeguards hematopoiesis and genome integrity in hematopoietic stem cells and leukemia cells
To decipher the role of USP15 in DNA damage in leukemia cells, endogenous USP15 was immunoprecipitated from MV4-11 and Kasumi-1 cell lines under naive and DNA stress conditions (Mitomycin C, 30nM, 1h). 355 candidates co-immunoprecipitated with USP15 in all the conditions, in 4 independent experiment...
ORGANISM(S): Homo sapiens (Human) 
2021-01-04 | PXD020612 | Pride
Human Dna damage Ubiquitin 
UnknownGeneralized transduction of small Yersinia enterocolitica plasmids.
Not available
S-EPMC99712 | biostudies-literature
ProteomicsProtective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection
The antiviral immune response to SARS-CoV-2 infection can limit viral spread and prevent development of pneumonic COVID-19. However, the protective immunological response associated with successful viral containment in the upper airways remain unclear. Here, we combine a multiomics approach with lon...
ORGANISM(S): Homo sapiens (Human) 
2022-01-17 | PXD030785 | Pride
Human Plasma Sars-cov-2 Proteomics Covid-19 
ProteomicsDeep Coverage Multi-omic Profiling of C2C12 Dexamethasone Skeletal Muscle Atrophy
Skeletal muscle atrophy and weakness are major contributors to morbidity, prolonged recovery, and long-term disability across a wide range of diseases. Atrophy is caused by breakdown of sarcomeric proteins resulting in loss of muscle mass and strength. Molecular mechanism underlying the onset of mus...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-14 | PXD064871 | Pride
Differentiation C2c12 Skeletal muscle atrophy Dexamethasone Tmt-ms 
ProteomicsPlasma Proteomics Analysis of a Transglutaminase 2 inhibitor in Celiac Disease
Individuals with celiac disease (CeD) on a long-term gluten-free diet (GFD) underwent a 6-week gluten challenge combined with 100mg per day of the transglutaminase 2 enzyme -inhibitor, ZED1227 (PGCd, n = 28) or placebo (PGCp, n = 19). The samples were collected at baseline (GFD) and post-gluten chal...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD069597 | Pride
Human Lc_msms Celiac disease Plasma 
UnknownRole of Muller cell cytochrome P450 2c44 in murine retinal angiogenesis.
Not available
S-EPMC6957927 | biostudies-literature
UnknownAtrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy development.
Not available
S-EPMC10730244 | biostudies-literature
UnknownPublic information needs and preferences on COVID-19: a cross-sectional study.
Not available
S-EPMC9969022 | biostudies-literature
Proteomics2020_Human BAK125 kit _Room Temperature
We assessed the impact of leaving a lyophilized mixture consisting of 125 peptides at room temperature for up to 20 days, and we assessed the effect on the quantitative performance of multiple reaction monitoring-MS (MRM-MS) assays. The findings suggest that there are no significant differences in t...
ORGANISM(S): Homo Sapiens 
2022-09-05 | PXD028179 | panorama
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