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ProteomicsNucleolar-nucleoplasmic shuttling of the RNA-binding macrodomain-containing TARG1 is controlled by DNA damage-induced poly-ADP-ribose and implies functions in ribosome biogenesis
In this project we employed affinity purification mass spectrometry to determine the interactome of the macrodomain containing protein TARG1/OARD1. TARG1 functions as a hydrolase towards mono-ADP-ribosylation (MARylation). TARG1 sowed strong binding to ribosomes and proteins associated with rRNA pro...
ORGANISM(S): Homo sapiens (Human) 
2018-04-23 | PXD008748 | Pride
Human Ap-ms Adp-ribosylation 
ProteomicsMultidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal and malignant urothelial cells
Epigenetic regulators, such as the SWI/SNF complex, play an important role in tissue development and homeostasis, and are frequently mutated in cancer. ARID1A, a subunit of the SWI/SNF complex, is mutated in approximately 20% of all bladder tumors, however, our understanding of the consequences ther...
ORGANISM(S): Homo sapiens (Human) 
2025-03-02 | PXD054817 | Pride
Human Ap-ms Urothelial cell lines 
ProteomicsPharmacological induction of selective endoplasmic reticulum retention as a novel strategy for cancer therapy
We analysed the difference in the surface proteome of human cells that were either subjected to ER stress (induced by thapsigargin (Tg)) only or were additionally treated with a pharmacological inhibitor against the eIF2α kinase PERK, which is localized in the endoplasmic reticulum. Compared to sin...
ORGANISM(S): Homo sapiens (Human) 
2020-03-02 | PXD014709 | Pride
Lc-ms Human Plasma membrane 
ProteomicsDual targeting of BCR-ABL1 and IRE1α is a promising therapeutic strategy in Ph+ ALL
BCR-ABL positive acute lymphoblastic leukemia (ALL) cell survival is strongly dependent on the IRE1α-XBP1 branch of the Unfolded Protein Response (UPR). In the study at hand, we have focused on exploring the link between BCR-ABL1 and IRE1α to better understand whether a simultaneous pharmacological ...
ORGANISM(S): Homo sapiens (Human) 
2020-09-21 | PXD012024 | Pride
Cell death Bcr-abl1 Ph+ all Ire1α Map kinase Treatment 
ProteomicsIgG-independent co-aggregation of FceRI and FcgRIIB results in LYN- and SHIP1-dependent tyrosine phosphorylation of FcgRIIB
We used tyrosine phosphorylation profiling by anti-pTyr-antibody mediated enrichment and subsequent analysis by mass spectrometry in order to determine the changes in early signalling after mast cell activation. Mast cells were stimulated with varying concentrations of antigen for one minute and the...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-17 | PXD009318 | Pride
Tyrosine phosphorylation Mouse Mast cell activation 
ProteomicsPolypropylene mesh implantation for hernia repair triggers myeloid cell-dependent persistent inflammatory foreign body reaction
Polypropylene meshes that are commonly used for surgical groin hernia repair may trigger granulomatous foreign body reactions. Here, we show that asymptomatic patients display mesh-associated inflammatory granulomas long after surgery, which are dominated by monocyte-derived macrophages. In mice, su...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-24 | PXD009944 | Pride
Mouse Inflammation Chemokine Granuloma Macrophages Monocytes Biomaterial 
ProteomicsA highly conserved luminal ER exit motif in the pseudoproteases iRhom1 and iRhom2 is indispensable for TNF������ and EGF receptor ligand release
Membrane-tethered signalling proteins such as TNF������ and many EGF receptor ligands undergo shedding by the metalloproteinase ADAM17 to get released. The pseudoproteases iRhom1 and iRhom2 are important for the ER exit and activity of ADAM17. Yet, their structural requirements to promote ER exit re...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-05-25 | PXD016948 | Pride
Tnf������ Receptors Cell biology Egf 
ProteomicsAMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy
The AMP-activated protein kinase (AMPK) is a master sensor of the cellular energy status and is crucial for the adaptive response to limited energy availability. AMPK is implicated in the regulation of many cellular processes, including autophagy. However, the precise mechanisms by which AMPK contro...
ORGANISM(S): Homo sapiens (Human) 
2020-02-17 | PXD009968 | Pride
Human Autophagy Nanolc-msms Phosphorylation 
TranscriptomicsDual function of Jnk1 and Jnk2 in hepatocytes is essential to protect against toxic liver injury
BACKGROUND & AIMS: c-Jun N-terminal kinase (JNK)1 and JNK2 are expressed in hepatocytes and have overlapping and distinct functions. JNK proteins are activated, via phosphorylation, in response to acetaminophen- or CCl4-induced liver damage; the level of activation correlates with the degree of inju...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-59602 | biostudies-arrayexpress
ProteomicsHs_Hela-Ti-IMAC-HILIC_3D_FTETD
Hs_Hela-SCX-Ti-IMAC-HILIC_3D_FTETD
ORGANISM(S): Homo Sapiens (human) 
2013-12-31 | PAe005290 | PeptideAtlas
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