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MetabolomicsLipidomic analysis of lipid droplets from murine hepatocytes reveals distinct signatures for nutritional stress
Liver steatosis can be induced by fasting or high-fat diet. We investigated by lipidomic analysis whether such metabolic states are reflected in the lipidome of hepatocyte lipid droplets (LDs) from mice fed normal chow diet (FED), fasted (FAS), or fed a high-fat diet (HFD). LC-MS/MS at levels of lip...
2014-08-19 | MTBLS26 | MetaboLights
ProteomicsMyristic acid induces proteomic changes in primary murine hepatocytes
Myristic acid, the 14-carbon saturated fatty acid (C14:0), is usually associated with negative consequences for human health, and in particular its consumption is correlated to an increased cardiovascular disease risk. Since it is a little abundant into the cells, its specific properties and functio...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-01 | PXD009017 | Pride
Mouse Primary murine hepatocytes Myristic acid Lc-ms/ms 
GenomicsIFN-b treatment of primary murine hepatocytes
IFN-b treatment of primary murine hepatocytes
PRJNA628883 | ENA
GenomicsComparison of primary vs immortalized murine hepatocytes
Comparison of primary vs immortalized murine hepatocytes
PRJNA432701 | ENA
TranscriptomicsTGF-beta1-Induced Gene Expression Changes in Primary Murine Hepatocytes
We here compared gene expression profiles of primary murine hepatocytes (mPC) upon stimulation with 1 ng/ml TGF-beta1 for 20 min, 2 hours and 4 hours with untreated cells. Experiments were done in three independent replicates. The goal of this study was to determine genes regulated by TGF-beta1. 12 ...
ORGANISM(S): Mus musculus 
2013-04-10 | E-GEOD-45942 | biostudies-arrayexpress
TranscriptomicsAberrantly microRNA profiling in cancerous hepatocytes versus normal primary hepatocytes
MicroRNAs is a rapidly expanding area expected to change the way in which diseases will be diagnosed, treated and monitored in the future. Hepatocellular carcinoma (HCC) shows a rising incidence with high mortality but lack of effective targeted therapies. We identified the aberrantly expressed miRN...
ORGANISM(S): Homo sapiens 
2010-12-30 | E-GEOD-20077 | biostudies-arrayexpress
ProteomicsSIK2 phosphorylation in response to glucagon or insulin in murine hepatocytes
The phosphorylation state of human HA-tagged-SIK2, adenovirally introduced in murine hepatocytes (C57/BL/6 strain) was analysed in unstimulated and in response to glucagon- or insulin- treated conditions. Background:- LKB1 is a master kinase that regulates metabolism and growth through AMPK and 12 o...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2014-08-08 | PXD001032 | Pride
Hepatic glucose production Hepatocytes Camp Crtc2 Ampk Glucagon Ampk-related kinase Lkb1 Sik2 Insulin Creb 
TranscriptomicsGenome-wide comparison between IL-17 and combined TNF-alpha/ IL-17 induced genes in primary murine hepatocytes
Cytokines such as TNF-alpha and IL-1beta are known for their contribution to inflammatory processes in liver . In contrast, the cytokine IL-17 has not yet been assigned a role in liver diseases. IL-17 can cooperate with TNF-alpha to induce a synergistic response on several target genes in different ...
ORGANISM(S): Mus musculus 
2010-03-07 | E-GEOD-19272 | biostudies-arrayexpress
TranscriptomicsIFN-b treatment of primary murine hepatocytes
Primary murine hepatocytes were isolated from C57Bl/6J (wild type) animals and treated with 1000 U/mL IFN-b for 24h and compared to time-matched untreated controls.
ORGANISM(S): Mus musculus 
2020-09-28 | GSE149497 | GEO
TranscriptomicsExploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity (miRNA)
The well-defined battery of in vitro systems applied within chemical cancer risk assessment is often characterised by a high false-positive rate, thus repeatedly failing to correctly predict the in vivo genotoxic and carcinogenic properties of test compounds. Toxicogenomics, i.e. mRNA-profiling, has...
ORGANISM(S): Mus musculus 
2016-06-28 | E-GEOD-72014 | biostudies-arrayexpress
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