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GenomicsProtein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy
Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy
PRJNA854161 | ENA
ProteomicsInteractors of trapped protein from mitochondria from HeLa cells with stalled import TMT-MS
This study explores the consequences of import failure in mammalian cells; wherein, blocking the import machinery has profound effects on mitochondrial ultra-structure and dynamics, but, surprisingly, does not impact import. The explanation is an astonishing response involving intercellular mitochon...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD040098 | Pride
Mitochondria Hela Import Galactose 
ProteomicsHuman mitochondrial protein import proteomics LFQ
Most mitochondrial proteins are encoded in the nucleus and require mitochondrial import after translation in the cytosol. A number of mutations in the mitochondrial protein import machinery have been shown to lead to human pathologies. However, a lack suitable tools to measure mitochondrial protein ...
ORGANISM(S): Homo sapiens (Human) 
2021-12-18 | PXD024054 | Pride
Meprod Mitochondrial import Lfq Human 
ProteomicsHuman mitochondrial protein import proteomics - Proteinase K control
Most mitochondrial proteins are encoded in the nucleus and require mitochondrial import after translation in the cytosol. A number of mutations in the mitochondrial protein import machinery have been shown to lead to human pathologies. However, a lack suitable tools to measure mitochondrial protein ...
ORGANISM(S): Homo sapiens (Human) 
2021-12-20 | PXD024066 | Pride
Meprod Tmd Tmt Mitochondrial protein import Human Dda 
ProteomicsHuman mitochondrial protein import proteomics
Most mitochondrial proteins are encoded in the nucleus and require mitochondrial import after translation in the cytosol. A number of mutations in the mitochondrial protein import machinery have been shown to lead to human pathologies. However, a lack suitable tools to measure mitochondrial protein ...
ORGANISM(S): Homo sapiens (Human) 
2021-12-18 | PXD022521 | Pride
Meprod Tmt Mitochondrial import Human Pulsed silac 
GenomicsMitochondrial protein import clogging as a mechanism of disease
Mitochondrial protein import clogging as a mechanism of disease
PRJNA944597 | ENA
UnknownRole of the Mitochondrial Protein Import Machinery and Protein Processing in Heart Disease.
Not available
S-EPMC8505727 | biostudies-literature
ProteomicsProtein import defects induce mitophagy without membrane depolarization
Upon mitochondrial dysfunction, mitophagy has been described to be activated by a breakdown of membrane potential leading to PINK1 accumulation on the outer membrane and engulfment of mitochondria for degradation. However, recent findings have indicated that mitophagy may also be triggered in the ab...
ORGANISM(S): Homo sapiens (Human) 
2022-09-03 | PXD022560 | Pride
Mitophagy Protein misfolding Mitochondrial protein import Pulsed-silac 
UnknownThe selectivity filter of the mitochondrial protein import machinery.
Not available
S-EPMC7596997 | biostudies-literature
UnknownReconstructing the mitochondrial protein import machinery of Chlamydomonas reinhardtii.
Not available
S-EPMC2390594 | biostudies-literature
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