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MetabolomicsExamination of human osteoarchaeological remains as a feasible source of polar and apolar metabolites to study past conditions
Metabolomics is a modern tool that aids in our understanding of the molecular changes in organisms. Archaeological science is a branch of archaeology that explores different archaeological materials using modern analytical tools. Human osteoarchaeological material are a frequent finding in archaeolo...
2022-07-04 | MTBLS4437 | MetaboLights
MetabolomicsThe Role of Annexin A1 in Candida albicans and Candida auris infections in murine neutrophils

Annexin A1 (AnxA1) is an anti-inflammatory protein present in different cells in biological systems, especially expressed in macrophages and neutrophils. Since neutrophils play an important role in infections and inflammatory processes and the AnxA1 and its relation in Candida spp. infections is ...

2021-12-03 | MTBLS2288 | MetaboLights
MetabolomicsPlasma Lipid Profile Reveals Plasmalogens as Potential Biomarkers for Colon Cancer Screening

In this era of precision medicine, there is an increasingly urgent need for highly sensitive tests for detecting tumors such as colon cancer (CC), a silent disease where the first symptoms may take 10-15 yr to appear. Mass spectrometry-based lipidomics is an emerging tool for such clinical diagno...

2023-11-13 | MTBLS1584 | MetaboLights
MetabolomicsSerum Predose Metabolic Profiling For Prediction Of Rosuvastatin Pharmacokinetic Parameters In Healthy Volunteers
Rosuvastatin is a quite known lipid-lowering agent generally used for hypercholesterolemia treatment and coronary artery diseases prevention. There is substantial inter-individual variability in the absorption of statins usually caused by genetic polymorphisms leading to variation in the correspondi...
2021-10-29 | MTBLS3128 | MetaboLights
MetabolomicsBotanical collections as an opportunity to explore nature through the time: An untargeted metabolomic study in historical and modern Nicotiana leaves

The living and dried specimens in botanical collections play an important role in society for scientific and recreational purposes, offering the opportunity to obtain both macroscopic and molecular information for individual plants, ecosystems, and environmental studies. Untargeted metabolomics i...

2024-03-06 | MTBLS4564 | MetaboLights
ProteomicsHydrogen utilization by Methylocystis sp. strain SC2 expands the known metabolic versatility of type IIa methanotrophs
The objective of this study was to assess whether Methylocystis sp. strain SC2, as a representative for Methylocystis spp., can utilize hydrogen to optimize the biomass yield by mixed utilization of CH4 and H2, rather than CH4 as the sole source of energy. Thus, we aimed to show that, in the presenc...
ORGANISM(S): Methylocystis sp. SC2 Bacteria 
2020-06-03 | PXD015700 | Pride
Metabolic model Knallgas bacteria Proteomics Methylocystis Hydogenase Methanotrophs 
ProteomicsThe mitochondrial methylation potential gates early and late ribosome assembly
S-adenosylmethionine (SAM) is the principal methyl group donor of the cell, required to modify various molecules, including DNA, RNA and proteins. Inside mitochondria, SAM is associated with several steps of mitochondrial gene expression. However, the exact role and significance of these modificatio...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-19 | PXD055907 | Pride
Sam Rna processing Elac2 Methylation Rnasep Mitochondrial ribosome Mitochondrial translation S-adenosylmethionine Samc Rnasez Adomet Slc25a26 
ProteomicsBiotinylated MMH2 pulldown LCMS
Here, we present structural and mechanistic studies that define a trans-labeling covalent molecular glue mechanism. We found that a novel series of BRD4 molecular glue degraders act by recruiting the CUL4-DCAF16 ligase to the second bromodomain of BRD4. To gain a deeper understanding into the potent...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051457 | Pride
Human Lc-msms Molecular glue 
MetabolomicsUntargeted metabolomics workshop report: quality control considerations from sample preparation to data analysis

The Metabolomics workshop on experimental and data analysis training for untargeted metabolomics was hosted by the Proteomics Society of India in December 2019. The Workshop included six tutorial lectures and hands-on data analysis training sessions presented by seven speakers. The tutorials and ...

2020-12-17 | MTBLS1301 | MetaboLights
UnknownA genetically distinct pediatric subtype of primary CNS large B-cell lymphoma is associated with favorable clinical outcome.
Not available
S-EPMC9131901 | biostudies-literature
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