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UnknownData on mass spectrometry-based proteomics for studying the involvement of CYLD in the ubiquitination events downstream of EGFR activation.
Not available
S-EPMC5997975 | biostudies-literature
ProteomicsDNA polymerase kappa is the primary translesion synthesis polymerase for aldehyde ICLs
DNA interstrand crosslinks (ICLs) are highly cytotoxic lesions that block essential cellular processes like replication and transcription. Endogenous ICLs can be induced by reactive aldehydes produced during normal cellular metabolism. Defective repair of these aldehyde-induced ICLs is associated wi...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2025-09-29 | PXD066315 | Pride
Dna polymerase kappa Acrolein-icl Translesion synthesis Fanconi anemia pathway Acetaldehyde-icl 
UnknownChanges in Gab2 phosphorylation and interaction partners in response to interleukin (IL)-2 stimulation in T-lymphocytes.
Not available
S-EPMC4812247 | biostudies-literature
UnknownSILAC-based quantification of changes in protein tyrosine phosphorylation induced by Interleukin-2 (IL-2) and IL-15 in T-lymphocytes.
Not available
S-EPMC4564383 | biostudies-literature
ProteomicsEGF-dependent ubiquitinome, phosphorylation and interactome analysis in control and CYLD-deficient cells
The goal of the present project was to investigate the EGF-dependent ubiquitination changes occurring in HeLa cells upon a CYLD deficiency. We applied SILAC-based quantitative mass spectrometry proteomics together with genetic engineering and biochemical approaches, in order to enrich the ubiquitina...
ORGANISM(S): Homo sapiens (Human) 
2017-06-05 | PXD003423 | Pride
Ubiquitination Egf Cyld 
UnknownEffectiveness and safety of first-generation protease inhibitors in clinical practice: Hepatitis C virus patients with advanced fibrosis.
Not available
S-EPMC4533049 | biostudies-literature
UnknownCylindromatosis Tumor Suppressor Protein (CYLD) Deubiquitinase is Necessary for Proper Ubiquitination and Degradation of the Epidermal Growth Factor Receptor.
Not available
S-EPMC5546196 | biostudies-literature
ProteomicsAdipose MDM2 regulates systemic insulin sensitivity through nuclear import of MORC2 and the PPARγ cofactor LIPIN1
The intimate association between obesity and type II diabetes urges for a deeper understanding of adipocyte function. We and others have previously delineated a role for the tumor suppressor p53 in adipocyte biology. Here, we show that mice haploinsufficient for MDM2, a key regulator of p53, in thei...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD020812 | Pride
Morc2 Obesity Pparγ C/ebp Mdm2 Lipin1 
UnknownNormal cell cycle progression requires negative regulation of E2F1 by Groucho during S phase and its relief at G2 phase.
Not available
S-EPMC10281550 | biostudies-literature
ProteomicsMapping functional non-coding variation in individual human genomes through haplotyping, multiomics, and deep learning
Most genetic variants in the human genome reside in non-coding regions, where they can perturb regulatory elements, influence gene expression, and contribute to various phenotypes and diseases. However, identifying such functionally relevant genetic variation remains challenging. Here we integrate p...
ORGANISM(S): Homo sapiens (Human) 
2026-04-22 | PXD069116 | Pride
Lc-msms Non-coding variants Deep learning 
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