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ProteomicsSystem-level analysis of cancer and stomal cell specific proteomes reveals extensive reprogramming of phosphorylation networks by tumor microenvironment
DLD-1 cells and mouse were treated with DMSO, GDC0941 and CAL101 for 2 hours. Proteins were digested with trypsin and phospho peptides were enriched using TiO2. Enriched phosphopeptides and peptides were analysed by LTQ Orbitrap Velos mass spectrometer. (MS/MS data were converted to mgf files usin...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2014-04-02 | PXD000218 | Pride
Dld-1 cells Proteomics Phosphoproteomics 
UnknownBeta cyclodextrin stabilized cupric oxide nanoparticles assisted thermal therapy for lung tumor and its effective in vitro anticancer activity.
Not available
S-EPMC12332176 | biostudies-literature
UnknownThe Src inhibitor peptide TAT-Cx43<sub>266-283</sub> improves survival in an intracranial murine model of lung cancer brain metastasis.
Not available
S-EPMC12932952 | biostudies-literature
ProteomicsIntegrative proteo-genomic profiling uncovers key biomarkers of lapatinib resistance in HER2-positive breast cancer
To understand the transcriptomic, genomic and proteomics changes between HER2 overexpressingcells and those that have become resistant to lapatinib
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD056848 | Pride
3d Chromatin Proteomics Epigenetics Resistance Her2 Lc-ms/ms 
ProteomicsHuman omentum from patients with High-grade serous ovarian cancer
High-resolution multi-layered profiling of human ovarian cancer metastases.
ORGANISM(S): Homo sapiens (Human) 
2018-02-20 | PXD004060 | Pride
Lc-ms/ms Human Ovarian cancer Matrisome Extracellular matrix 
UnknownThe cytotoxic action of BCI is not dependent on its stated DUSP1 or DUSP6 targets in neuroblastoma cells.
Not available
S-EPMC9249316 | biostudies-literature
UnknownKinase activity ranking using phosphoproteomics data (KARP) quantifies the contribution of protein kinases to the regulation of cell viability.
Not available
S-EPMC5587867 | biostudies-literature
ProteomicsFAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer
Cancer-associated fibroblasts (CAFs), although considered as the most abundant pancreatic ductal adenocarcinoma (PDAC) stromal cells playing a critical role in tumor progression and chemoresistance, are not yet directly druggable. Here we report that focal adhesion kinase (FAK) activity (evaluated b...
ORGANISM(S): Homo sapiens (Human) 
2020-08-19 | PXD018899 | Pride
Fak Cancer-associated fibroblasts Pancreatic cancer Extracellular matrix 
ProteomicsElucidation of BMI1, RYBP and H2AK119ub interactomes in Glioblastoma
Identification of BMI1, RYBP and H2AK119UB interactome in Glioblastoma (GBM) to elucidate BMI1 roles independent of the PRC1-complex in GBM.
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022057 | Pride
H2ak119ub Bmi1 Proteomics Glioblastoma Ipms Chipms Rybp Gbm Lc-ms/ms 
ProteomicsSFX-01 is therapeutic against myeloproliferative disorders caused by activating mutations in Shp2
• Activating mutations of Shp2 cause conditions such as Noonan syndrome and juvenile myelomonocytic leukemia (JMML), with unmet therapeutic needs. • SFX-01, a sulforaphane complex, modifies cysteine residues and targets proteins including Shp2, where it induces an inhibitory modification at the acti...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-12 | PXD061655 | Pride
Shp2 Sfx-01 Myeloid cell proliferation Noonan syndrome Phosphoproteomics Lc-ms/ms 
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