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MetabolomicsLiquid Chromatography-High-Resolution Mass Spectrometry-Based In Vitro Toxicometabolomics of the Synthetic Cathinones 4-MPD and 4-MEAP in Pooled Human Liver Microsomes
Synthetic cathinones belong to the most often seized new psychoactive substances on an international level. This study investigated the toxicometabolomics, particularly the in vitro metabolism of 2-(methylamino)-1-(4-methylphenyl)-1-pentanone (4-MPD) and 2-(ethylamino)-1-(4-methylphenyl)-1-pentanone...
2023-11-28 | MTBLS2218 | MetaboLights
ProteomicsProteomic Analysis of Rat Liver Microsomes by 2D-LC-MSMS
Liver plays a crucial role in numerous metabolic processes and therefore is the primary target of study in drug discovery and molecular toxicology. Devising an appropriate analytical strategy for an efficient analysis of the liver samples has been a major concern in proteomics. The aim of this study...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-03-26 | PXD000720 | Pride
2d-lc-msms Tripletof Rat liver microsomes Proteinpilot 
ProteomicsRat Liver Microsomes by 2D-LC-MS/MS
Rat liver microsomes were analysed using offline strong cation exchange fractionation followed by reverse-phase chromatography coupled to quadrupole-time-of-flight high-resolution mass spectrometry using trypsin and pepsin parallel digestions. MS/MS files were searched against the UniProt protein da...
ORGANISM(S): Rattus norvegicus (Rat) 
2013-02-19 | PXD000128 | Pride
Rat Strong cation exchange Microsomes Pepsin Liver Trypsin Qqtof 
ProteomicsProteomic Analysis of Human Liver Microsomes by 2D-LC-MSMS
Liver plays a crucial role in numerous metabolic processes and therefore is the primary target of study in drug discovery and molecular toxicology. Devising an appropriate analytical strategy for an efficient analysis of the liver samples has been a major concern in proteomics. The aim of this study...
ORGANISM(S): Homo sapiens (Human) 
2015-03-26 | PXD000721 | Pride
2d-lc-msms Tripletof Proteinpilot Human liver microsomes 
ProteomicsProteomic Analysis of Mouse Liver Microsomes by 2D-LC-MSMS
Liver plays a crucial role in numerous metabolic processes and therefore is the primary target of study in drug discovery and molecular toxicology. Devising an appropriate analytical strategy for an efficient analysis of the liver samples has been a major concern in proteomics. The aim of this study...
ORGANISM(S): Mus musculus (Mouse) 
2015-03-26 | PXD000731 | Pride
Mouse liver microsomes 2d-lc-msms Tripletof Proteinpilot 
ProteomicsFunctional proteomics of membrane lipid domains after Brij 98 solubilization of uninduced and phenobarbital-induced rat liver microsomes: Defining the membrane localization of the P450 enzyme system
In this study, we use Brij 98 to determine the lipid domain distribution of the ER proteome in rat liver microsomes with emphasis on that of the P450 enzyme system. Because of the profound effects of phenobarbital treatment on protein expression and lipid biosynthesis, we will examine the liver ER p...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-04-27 | PXD022460 | Pride
Tmt discovery based proteomics P450s Liver microsomes 
ProteomicsProteomic Analysis of Rat Liver S9 Fraction by 2D-LC-MSMS
Liver plays a crucial role in numerous metabolic processes and therefore is the primary target of study in drug discovery and molecular toxicology. Devising an appropriate analytical strategy for an efficient analysis of the liver samples has been a major concern in proteomics. The aim of this study...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-03-26 | PXD000717 | Pride
2d-lc-msms Tripletof Proteinpilot Rat liver s9 fraction 
ProteomicsAcetaminophen Adducts of Rat Liver Microsomal Proteins using LC-MSMS
The metabolism of xenobiotics in the liver can give rise to reactive metabolites that may covalently bind to tissue macromolecules, such as proteins. Determination of proteins which are targeted by reactive metabolites is of importance in drug discovery and molecular toxicology. However, there are d...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-11-04 | PXD002590 | Pride
Napqi High-resolution tandem mass spectrometry Reactive metabolites Acetaminophen Rat liver microsomes Drug-induced liver injury Covalent binding 
ModelsSiramshetty2020 - Assessment of rat liver microsomal stability with QSAR models.
Hepatic metabolic stability is key to ensure the drug attains the desired concentration in the body. The Rat Liver Microsomal (RLM) stability is a good approximation of a compound’s stability in the human body, and NCATS has collected a proprietary dataset of 20216 compounds with its associated RLM ...
2024-04-22 | MODEL2404220002 | BioModels
Machine Learning Model FAIR-AIML Ersilia 
UnknownStructural Features Governing the Metabolic Stability of Tetraethyl-Substituted Nitroxides in Rat Liver Microsomes.
Not available
S-EPMC9952648 | biostudies-literature
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