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MetabolomicsRedox proteomics reveal a role for peroxiredoxinylation in stress protection.

The redox state of proteins is essential for their function and guarantees cell fitness. Peroxiredoxins protect cells against oxidative stress, maintain redox homeostasis, act as chaperones, and transmit hydrogen peroxide signals to redox regulators. Despite the profound structural and functional...

2025-07-17 | MTBLS11979 | MetaboLights
ProteomicsRedox Proteomics Analysis of Auranofin Exposed Ovarian Cancer Cells
The effects of Auranofin (AF) on protein expression and protein oxidation in A2780 cancer cells were explored through a robust investigative strategy based on joint expression proteomics and redox proteomics determinations. Bioinformatics analysis of the proteomics data supports the view that the mo...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD028681 | Pride
Cysteine Auranofin Gold Ovarian cancer Redox proteomics 
ProteomicsAnticancer effect of deuterium depleted water - comprehensive proteomics analysis suggests a redox disbalance mechanism
The proteomics data is derived from 4 parts of samples prepared and analysed by nanoLC-MS/MS. In order to make appropriate statistical analysed could be performed, all treatments were performed in biological replicates. The number of replicates was 4 for protein abundances analysis (part 1), 2 for t...
ORGANISM(S): Homo sapiens (Human) 
2019-09-26 | PXD011085 | Pride
Anticancer Proteomics Redox disbalance Deuterium depleted water 
UnknownThiol redox proteomics: Characterization of thiol-based post-translational modifications.
Not available
S-EPMC10764013 | biostudies-literature
UnknownRedox proteome analysis of auranofin exposed ovarian cancer cells (A2780).
Not available
S-EPMC8966199 | biostudies-literature
ProteomicsComprehensive chemical proteomics for target deconvolution of the redox active drug auranofin
Chemical proteomics encompasses novel drug target deconvolution methods in which compound modification is not required. Herein we use Thermal Proteome Profiling, Functional Identification of Target by Expression Proteomics and multiplexed redox proteomics for deconvolution of auranofin targets to ai...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD016776 | Pride
Cancer Nfkb2 Mass spectrometry Hct116 Thioredoxin reductase Expression Chordc1 Database A375 Drug Proteomics Resource Rko Chemotherapeutic Auranofin Compound 
ProteomicsMechano-redox control of Mac-1 de-adhesion from ICAM-1 by protein disulfide isomerase promotes directional movement under flow
Quantification of the redox state of disulfide bonds in the beta 2 subunit of human recombinant Mac-1 integrin.
ORGANISM(S): Homo sapiens (Human) 
2023-04-09 | PXD032688 | Pride
Mac-1 Disulfide bonds Redox state 
ProteomicsSpecificity and dynamics of H2O2 detoxification by the cytosolic redox regulatory network as revealed by in vitro reconstitution
The thiol redox state is a decisive functional characteristic of proteins in cell biology. Plasmatic cell compartments maintain a thiol-based redox regulatory network linked to the glutathione/glutathione disulfide couple (GSH/GSSG) and the NAD(P)H system. The basic network constituents are known an...
ORGANISM(S): Escherichia Coli 
2025-01-21 | PXD048374 | JPOST Repository
ProteomicsRedox proteome analysis identifies reversible oxidized proteins in retinoic acid differentiated SH-SY5Y cells
Retinoic acid stimulated SH-SY5Y cells are a common model system to study the initial phases of neuronal differentiation. Although these processes are associated with redox-sensitive processes, no comprehensive analysis of oxidative modified cysteines, as one of the main targets for reactive oxygen ...
ORGANISM(S): Homo sapiens (Human) 
2020-03-30 | PXD014381 | Pride
Dynamics Neuronal differentiation Redox Redox proteomics 
ProteomicsAnalysis of cysteine redox state with age in flies overexpressing catalase
Dysregulation of redox homeostasis has been implicated in the ageing process and the pathology of age-related diseases. To study redox signalling by hydrogen peroxide in vivo, we upregulated levels of the enzyme catalase in Drosophila.
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-06-30 | PXD060330 | Pride
Drosophila Catalase Ageing 
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