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ProteomicsThe composition of reticular adhesions in RPMI-7951 and MDA-MB-435S melanoma cell lines and its comparison with the reticular adhesion composition following talin2 or KANK2 knockdown
Integrins bind extracellular matrix proteins and, when clustered, form integrin adhesion complexes (IACs) that connect to and regulate the cytoskeleton, shaping normal and tumour cell behaviour. In addition to well-known nascent adhesions, focal adhesions (FAs), fibrillar adhesions (FBs), and hemide...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD071922 | Pride
Reticular adhesions Kank2 Matrisome Adhesome Melanoma Rpmi-7951 cells Integrin alphavbeta5 Talin2 Mda-mb-435s cells 
ProteomicsU2OS Adhesion Isolations +/- CytochalasinD and Neomycin
U2OS cells preferentially utilise integrin alphaV beta5 in adhesion complexes when grown under standard cell culture conditions for 3 days. AlphaV beta5 can be found in both classical 'Focal' adhesions and in novel 'Reticular' adhesions that do not associate with F-actin or other known adhesion prot...
ORGANISM(S): Homo sapiens (Human) 
2019-06-03 | PXD008680 | Pride
Human Cytod Reticular U2os Proteomics 
UnknownReticular adhesions are assembled at flat clathrin lattices and opposed by active integrin α5β1.
Not available
S-EPMC10225744 | biostudies-literature
UnknownEvaluation of synthetic reticular hybrid meshes designed for intraperitoneal abdominal wall repair: Preclinical and in vitro behavior.
Not available
S-EPMC6392302 | biostudies-literature
UnknownLocal 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions.
Not available
S-EPMC4643399 | biostudies-literature
UnknownMultitier mechanics control stromal adaptations in the swelling lymph node.
Not available
S-EPMC9355878 | biostudies-literature
UnknownPopulation distributions of single-cell adhesion parameters during the cell cycle from high-throughput robotic fluidic force microscopy.
Not available
S-EPMC9095720 | biostudies-literature
ProteomicsHeLa and U2OS long term culture adhesion isolations
Integrin adhesion complexes have been previously isolated and analysed by mass-spectrometry from cells largely spread on matrix proteins over a couple of hours. Here we wished to determine the composition of adhesion complexes from cells cultured for 72 hours under standard cell culture conditions a...
ORGANISM(S): Homo sapiens (Human) 
2019-06-03 | PXD008645 | Pride
Human Cancer cell Proteomics Integrin Adhesion complex Cell culture 
UnknownNovel roles for scleraxis in regulating adult tenocyte function.
Not available
S-EPMC6081934 | biostudies-literature
UnknownPolycystin-1 Interacting Protein-1 (CU062) Interacts with the Ectodomain of Polycystin-1 (PC1).
Not available
S-EPMC10487028 | biostudies-literature
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