Sort   by:  
 Page size 
MetabolomicsRecombinant Production of Biliverdin IXβ and δ Isomers in the T7 Promoter Compatible Escherichia coli Nissle
The ability to obtain purified biliverdin IX (BVIX) isomers other than the commercially available BVIXα is limited due to the low yields obtained by the chemical coupled oxidation of heme. Chemical oxidation requires toxic chemicals, has very poor BVIX yields (<0.05%), and is not conducive to scalab...
2021-12-16 | MTBLS3555 | MetaboLights
GenomicsEpigenetic profiling in CD4 and CD8 T cells from Gravesâ?? disease patients reveals changes in genes associated with T cell receptor signaling [ChIP-seq]
In Gravesâ?? disease (GD), a combination of genetic, epigenetic and environmental factors causes an autoimmune response to the thyroid gland, characterized by lymphocytic infiltrations and autoantibodies targeting the thyroid stimulating hormone receptor (TSHR) and other thyroid antigens. To identif...
ORGANISM(S): Homo sapiens 
2015-11-06 | E-GEOD-71952 | biostudies-arrayexpress
TranscriptomicsT cell acute leukaemia development and chemo-resistance are mediated by dynamic interactions with heterogeneous bone marrow microenvironments.
It is widely accepted that complex interactions between cancer cells and their surrounding microenvironment contribute to disease development, chemo-resistance and disease relapse. In light of this observed interdependency, novel therapeutic interventions that target specific cancer stroma cell line...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-MTAB-4889 | biostudies-arrayexpress
GenomicsSTAT5 paralog dose governs T cell effector and regulatory function
The transcription factor STAT5 is fundamental to the mammalian immune system. However, the relationship between its two paralogs, STAT5A and STAT5B, and the extent to which they are functionally distinct, remains controversial. We addressed this longstanding question in primary CD4+ 'helper' T cells...
ORGANISM(S): Mus musculus 
2016-03-28 | E-GEOD-77656 | biostudies-arrayexpress
TranscriptomicsRNA-seq of CD8+ T cells from JSLE patients and healthy controls
Transcriptional profiling of peripheral blood CD8+ T cells from juvenile systemic lupus erythematosus (JSLE) patients and healthy controls.
ORGANISM(S): Homo sapiens 
2025-01-10 | E-MTAB-14531 | biostudies-arrayexpress
TranscriptomicsCXCR3+ Treg cells suppress Th1-immune responses through expression of the co-inhibitory receptors CD85k and Lag-3
CD4+Foxp3+ Treg cells are essential for maintaining self-tolerance and preventing excessive immune responses. In the context of Th1 immune responses, co-expression of the Th1 transcription factor T-bet with Foxp3 is essential for Treg cells to control Th1 responses. T-bet-dependent expression of CXC...
ORGANISM(S): Mus musculus 
2018-06-30 | E-MTAB-6156 | biostudies-arrayexpress
ProteomicsWhole Proteomics of 24 hr pan Pim kinase inhibitor treatment of IL2 cultured CD8 T cells
T cell antigen-receptor (TCR) and cytokine receptor engagement trigger large changes in Serine/Threonine kinase signalling networks to drive T cell activation and differentiation. The role of only few kinase signalling pathways have been studied in detail, and in this context, Pim kinases are an int...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-15 | PXD051214 | Pride
Lc-msms Pim447 Azd1208 Tofacitinib Mouse Pim1 Pim2 Cd8 t cell Cytotoxic t lymphocyte Pim kinase 
ProteomicsProteomics of 24 h TCR activated wild-type and Pim1/Pim2 double knockout CD4 and CD8 T cells
T cell antigen-receptor (TCR) and cytokine receptor engagement trigger large changes in Serine/Threonine kinase signalling networks to drive T cell activation and differentiation. The role of only few kinase signalling pathways have been studied in detail, and in this context, Pim kinases are an int...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-15 | PXD051198 | Pride
Lc-msms Mouse Pim1 Pim2 T lymphocyte Pim kinase 
ProteomicsProteomics of Day 6 IL-2 or IL-15 expanded wild-type and Pim1/Pim2 double knockout CD8+ T cells.
T cell antigen-receptor (TCR) and cytokine receptor engagement trigger large changes in Serine/Threonine kinase signalling networks to drive T cell activation and differentiation. The role of only few kinase signalling pathways have been studied in detail, and in this context, Pim kinases are an int...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-15 | PXD051213 | Pride
Lc-msms Mouse Pim1 Pim2 Cytotoxic t lymphocyte Pim kinase Il-2 Il-15 
TranscriptomicsRegulatory and effector T cells in Lymphocytic choriomeningitis virus WE infection
In this study, we determined the signature of CD4+Foxp3- effector T cells and CD4+Foxp3+ Treg cells in naive animals and following LCMV WE infection. In addition, transcriptional signatures were determined in CXCR3+ CD4+Foxp3+ Treg cells arising in Th1 settings following LCMV infection.
ORGANISM(S): Mus musculus 
2020-03-11 | E-MTAB-8861 | biostudies-arrayexpress
Sort   by:  
 Page size