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OtherComprehensive and reproducible phosphopeptide enrichment using iron immobilized metal ion affinity chromatography (Fe-IMAC) columns.
Data from ProteomeXchange, PXD ID: PXD001060. File: 00730_A11_P005652_S00_T01_R1.mzml. Published as part of Mol Cell Proteomics. 2015 Jan;14(1):205-15 . From the Abstract: {{i}} ... Current offline enrichment approaches using TiO(2), Ti, and Fe immobilized metal ion affinity chromatography (IMAC) m...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32310023168 | GPMDB
Resource Reanalysis 
ProteomicsEvaluation of of kinase acitivity profiling using chemical proteomics
Evaluation of kinase binding to immobilized inhibitors upon kinase activation. Comparison of cheomproteomic binding changes to phosphoproteomic activation profiles.
ORGANISM(S): Homo sapiens (Human) 
2016-01-04 | PXD002635 | Pride
Mass spectrometry Phosphoprotoemics Chemical proteomics Activity Kinase 
ProteomicsmiRNA regulation - Proteomic response of mammalian cells to miRNA treatment
Proteomic response of mammalian cells to miRNA treatment
ORGANISM(S): Mus musculus (Mouse) 
2017-08-28 | PXD005569 | Pride
Proteomics Mirna 
ProteomicsFe-IMAC column based phospho enrichment
Fe-IMAC columns for robust and reproducible phosphopeptide ernichment, comparison to TiO2 batch and Ti-IMAC tip enrichment, large scale phosphoproteomics coupling Fe-IMAC column pre-enrichment to subsequent hSAX separation
ORGANISM(S): Homo sapiens (Human) 
2015-08-19 | PXD001060 | Pride
Hsax Tio2 Ti-imac Ptm Phospho Fe-imac 
ProteomicsChemoproteomic profiling to identify activity changes and functional inhibitors of DNA-binding proteins
DNA-binding proteins are promising therapeutic targets but notoriously difficult to drug. Here, we evaluate a chemoproteomic DNA interaction platform as a complementary strategy for parallelized compound profiling. To enable this approach, we determined the proteomic binding landscape of 92 immobili...
ORGANISM(S): Homo sapiens (Human) 
2023-02-03 | PXD037297 | Pride
Reactive side chain profiling Mass spectrometry Drug screening Pull-down Covalency Dna binding Chemical proteomics 
ProteomicsA mass spectrometry-based proteome map of drug action in lung cancer cell lines Part 4
Mass spectrometry-based discovery proteomics is an essential tool for the proximal read-out of cellular drug action. Here, we used a robust proteomic workflow to rapidly and systematically profile the proteomes of five cell lines in response to > 50 drugs. We found that aggregating millions of quant...
ORGANISM(S): Homo sapiens (Human) 
2020-08-17 | PXD018572 | Pride
Mass spectrometry Drug discovery Proteomics Perturbation profiling 
ProteomicsA mass spectrometry-based proteome map of drug action in lung cancer cell lines Part 6
Mass spectrometry-based discovery proteomics is an essential tool for the proximal read-out of cellular drug action. Here, we used a robust proteomic workflow to rapidly and systematically profile the proteomes of five cell lines in response to > 50 drugs. We found that aggregating millions of quant...
ORGANISM(S): Homo sapiens (Human) 
2020-08-17 | PXD018574 | Pride
Mass spectrometry Drug discovery Proteomics Perturbation profiling 
ProteomicsA mass spectrometry-based proteome map of drug action in lung cancer cell lines Part 3
Mass spectrometry-based discovery proteomics is an essential tool for the proximal read-out of cellular drug action. Here, we used a robust proteomic workflow to rapidly and systematically profile the proteomes of five cell lines in response to > 50 drugs. We found that aggregating millions of quant...
ORGANISM(S): Homo sapiens (Human) 
2020-08-17 | PXD018571 | Pride
Mass spectrometry Drug discovery Proteomics Perturbation profiling 
ProteomicsA mass spectrometry-based proteome map of drug action in lung cancer cell lines
Mass spectrometry-based discovery proteomics is an essential tool for the proximal read-out of cellular drug action. Here, we used a robust proteomic workflow to rapidly and systematically profile the proteomes of five cell lines in response to > 50 drugs. We found that aggregating millions of quant...
ORGANISM(S): Homo sapiens (Human) 
2020-08-17 | PXD018569 | Pride
Mass spectrometry Drug discovery Proteomics Perturbation profiling 
ProteomicsA mass spectrometry-based proteome map of drug action in lung cancer cell lines
Mass spectrometry-based discovery proteomics is an essential tool for the proximal read-out of cellular drug action. Here, we used a robust proteomic workflow to rapidly and systematically profile the proteomes of five cell lines in response to > 50 drugs. We found that aggregating millions of quant...
ORGANISM(S): Homo sapiens (Human) 
2020-08-17 | PXD018573 | Pride
Mass spectrometry Drug discovery Proteomics Perturbation profiling 
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