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ProteomicsMicroprotein discovery in HEK293T and K562 cells
The objective of this project is to identify novel microproteins in HEK293T and K562 cell lysates with subsequent fractionation, for the purpose of identifying predicted microproteins from the tool ShortStop.
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD050875 | Pride
Microprotein Lc ms/ms 
ProteomicsImproved Identification and Analysis of Small Open Reading Frame Encoded Polypeptides
Computational, genomic, and proteomic approaches have been used to discover nonannotated proteincoding small open reading frames (smORFs). Some novel smORFs have crucial biological roles in cells and organisms, which motivates the search for additional smORFs. Proteomic smORF discovery methods are a...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-06-26 | MSV000084014 | MassIVE
ProteomicsRegulation of the ER stress response by a mitochondrial microprotein
Cellular homeostasis relies on having dedicated and coordinated responses to a variety of stresses. The accumulation of unfolded proteins in the endoplasmic reticulum (ER) is a common stress that triggers a conserved pathway called the unfolded protein response (UPR) that mitigates damage, and dysre...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD014890 | Pride
Mitochondrial Smorfs Microprotein Er stress response 
ProteomicsImproved Identification and Analysis of Small Open Reading Frame Encoded Polypeptides
Computational, genomic, and proteomic approaches have been used to discover nonannotated proteincoding small open reading frames (smORFs). Some novel smORFs have crucial biological roles in cells and organisms, which motivates the search for additional smORFs. Proteomic smORF discovery methods are a...
ORGANISM(S): Homo sapiens (Human) 
2017-10-17 | PXD005643 | Pride
Smorf-encoded polypeptides (seps) Lc-ms 
ProteomicsAbnormal mitochondrial structure and function in brown adipose tissue of SLC35A4-MP knockout mice
Uncovering the role of upstream ORFs (uORFs) challenges conventional views of one protein per mRNA while also revealing the capacity of some uORFs to encode microproteins that contribute to cellular biology and physiology. This study explores the functional role of a recently identified mitochondria...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-29 | PXD066679 | Pride
Uorfs Microproteins Slc35a4 Upstream orfs 
ProteomicsAIG1 and ADTRP are endogenous FAHFA hydrolases
Fatty acid esters of hydroxy fatty acids (FAHFAs) are a newly discovered class of signaling lipids with anti-inflammatory and anti-diabetic activities. However, the endogenous regulation of FAHFAs remains a pressing but unanswered question. Here, we find that androgen- induced gene 1 (AIG1) and andr...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-09 | PXD017539 | Pride
Threonine hydrolase Metabolism Adtrp Lipid Enzyme inhibitor Fahfa Aig1 Diabetes 
TranscriptomicsK562 polyA RNA-Seq
RNA-Seq reads and TopHat (Trapnell et al. Bioinformatics 2009) alignments of K562 cell-line transcriptome. These were used to validate the expression of short peptides idenitified by Mass-Spectrometry in K562 cells. K562 polyA+ RNA (Batch 1) and total RNA (batch 2) was purchased from Ambion. We use...
ORGANISM(S): Homo sapiens 
2012-11-14 | E-GEOD-34740 | biostudies-arrayexpress
ProteomicsA Class of Anti-inflammatory Lipids Decrease with Aging in the Central Nervous System
Untargeted lipidomics of brain and spinal cord samples from female mice at 4, 12, 25, 48, and 78 weeks of age
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-08-22 | MSV000090179 | MassIVE
MetabolomicsGNPS - A Class of Anti-inflammatory Lipids Decrease with Aging in the Central Nervous System
Untargeted lipidomics of brain and spinal cord samples from female mice at 4, 12, 25, 48, and 78 weeks of age
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-08-22 | MSV000090179 | GNPS
ProteomicsIdentification of Microproteins in AD Using DIA Mass Spectrometry
Alzheimer’s disease (AD) is defined by abnormal protein accumulation and broad disruptions in proteostasis, yet most proteomic studies focus solely on annotated proteins. Microproteins are largely excluded because they are missing from standard reference databases. To address this gap, we performed ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-09 | PXD071500 | Pride
Brain Microproteins Dia 
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