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ProteomicsSIK2 phosphorylation in response to glucagon or insulin in murine hepatocytes
The phosphorylation state of human HA-tagged-SIK2, adenovirally introduced in murine hepatocytes (C57/BL/6 strain) was analysed in unstimulated and in response to glucagon- or insulin- treated conditions. Background:- LKB1 is a master kinase that regulates metabolism and growth through AMPK and 12 o...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2014-08-08 | PXD001032 | Pride
Hepatic glucose production Hepatocytes Camp Crtc2 Ampk Glucagon Ampk-related kinase Lkb1 Sik2 Insulin Creb 
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
UnknownOrigin of Earth's hydrogen and carbon constrained by their core-mantle partitioning and bulk Earth abundance.
Not available
S-EPMC12638987 | biostudies-literature
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAD targeted time-course)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7253 | MetaboLights
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Mouse NAMPT targeted therapy)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7252 | MetaboLights
UnknownBeta-lactam plus macrolide treatment versus beta-lactam monotherapy for community-acquired pneumonia: a propensity score analysis using data from a multicenter prospective cohort study.
Not available
S-EPMC12860014 | biostudies-literature
UnknownMultimodal mechanisms of human centriole engagement and disengagement
Not available
S-SCDT-10_1038-S44318-024-00350-8 | biostudies-other
ProteomicsProteome analysis of muscle, liver, and blood samples associated with cancer cachexia
We analyzed samples from multiple mouse cancer cacheixa modles and human gastric cancer patients by quantitative proteomics and protein acylation profiling.
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse) 
2023-08-04 | PXD035832 | JPOST Repository
ProteomicsProteome analysis of liver samples associated with cancer cachexia_sex
We analyzed samples from multiple mouse cancer cacheixa modles by quantitative proteomics.
ORGANISM(S): Mus Musculus (mouse) 
2023-08-04 | PXD042807 | JPOST Repository
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