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TranscriptomicsAn Integrated Approach to Uncover Drivers of Cancer
We developed a computational framework that integrates chromosomal copy number and gene expression data for detecting aberrations that promote cancer progression. We demonstrate the utility of this framework using a melanoma dataset. Our analysis correctly identified known drivers of melanoma and pr...
ORGANISM(S): Homo sapiens 
2010-12-01 | E-GEOD-23884 | biostudies-arrayexpress
MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
TranscriptomicsTranscriptomic analysis of the metabolic impact of higher oligopeptide assimilation mediated by horizontally acquired oligopeptide transporters Fot1/2 in wine strains.
To assess the impact of a higher oligopeptide assimilation mediated by Fot1/2, oligopeptides transporters acquired by HGT on wine yeast cell metabolism in winemaking conditions,we carried out a comparison of transcriptomic profiles of the wine wild type strain 59A and the deletion mutant of FOT1/2 g...
ORGANISM(S): Saccharomyces cerevisiae 
2016-01-19 | E-GEOD-62446 | biostudies-arrayexpress
UnknownMultiplex Tissue Imaging Harmonization: A Multicenter Experience from CIMAC-CIDC Immuno-Oncology Biomarkers Network.
Not available
S-EPMC9777693 | biostudies-literature
UnknownEffect of Sustained Smoking Cessation Counseling and Provision of Medication vs Shorter-term Counseling and Medication Advice on Smoking Abstinence in Patients Recently Diagnosed With Cancer: A Randomized Clinical Trial.
Not available
S-EPMC8094414 | biostudies-literature
ProteomicsCARM1 targeting potentiates IMiD activity: a novel approach to multiple myeloma therapy
Advancements in the treatment of multiple myeloma (MM) have resulted in significant improvement in the survival rate for patients <65, however not for patients >65. There is a particular need for improved therapies for this patient population. The protein arginine methyltransferase, CARM1 (coactivat...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD046700 | Pride
Ikzf1 Ikzf3 Ezm2302 Aiolos Imid Synergy Ikaros Multiple myeloma 
UnknownHigh throughput single-cell detection of multiplex CRISPR-edited gene modifications.
Not available
S-EPMC7574538 | biostudies-literature
UnknownSynergy between BRD9- and IKZF3-Targeting as a Therapeutic Strategy for Multiple Myeloma.
Not available
S-EPMC11010819 | biostudies-literature
UnknownEarly TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model.
Not available
S-EPMC7031028 | biostudies-literature
UnknownImpact of promoter polymorphisms in key regulators of the intrinsic apoptosis pathway on the outcome of childhood acute lymphoblastic leukemia.
Not available
S-EPMC3912962 | biostudies-literature
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