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ProteomicsThermal proteome profiling of phosphorylated proteoforms
We combined thermal proteome profiling (TPP) with phosphopeptide enrichment to study the thermostability of phosphorylated proteoforms.
ORGANISM(S): Homo sapiens (Human) 
2021-01-04 | PXD015993 | Pride
Phosphopeptides Meltome Phosphoproteomics Thermal proteome profiling 
ProteomicsThermal proteome profiling of cell cycle
We combined quantitative mass spectrometry with thermal profiling to systematically analyze the thermal stability and solubility of proteins during the eukaryotic cell cycle on a proteome-wide scale.
ORGANISM(S): Homo sapiens (Human) 
2018-05-02 | PXD008646 | Pride
Complexes Disordered proteins Cell cycle Thermal stability 
ProteomicsThermal proteome profiling in Escherichia coli
We adapted thermal proteome profiling (TPP) to study the thermostability of Escherichia coli proteins in vivo. We monitored the E. coli meltome and proteome at different growth phases, in a tolC knock-out mutant and after drug treatment.
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2018-07-09 | PXD009495 | Pride
Target engagement Escherichia coli Drugs Growth phase Meltome Thermal proteome profiling 
ProteomicsThermal proteome profiling of temporal dynamics of infection of SARS-CoV-2
We performed two dimensional thermal proteome profiling (2D-TPP) to profile the infection dynamics of SARS-CoV-2 infection in Caco-2 cells.
ORGANISM(S): Homo sapiens (Human) 
2020-11-23 | PXD022115 | Pride
Virus Sars-cov-2 Infection Coronavirus Thermal proteome profiling 
ProteomicsThermal proteome profiling of yeast phosphodeficient mutants
We performed two dimensional thermal proteome profiling (2D-TPP) of phosphodeficient mutantsof Saccharomyces cerevisiae.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-09-17 | PXD017929 | Pride
Saccharomyces cerevisiae Thermal proteome profiling Phosphomutants 
ProteomicsThermal proteome profiling of darobactin in Escherichia coli
We performed two dimensional thermal proteome profiling (2D-TPP) of darobactin to study its impact in Escherichia coli.
ORGANISM(S): Escherichia coli 
2019-10-29 | PXD013319 | Pride
Target engagement Darobactin Escherichia coli Drugs Thermal proteome profiling 
ProteomicsProteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP - SPP datasets
Nucleotide triphosphates (NTPs) regulate numerous biochemical processes in cells as (co-)substrates, allosteric modulators, biosynthetic precursors, and signaling molecules1-3. Apart from its roles as energy source fueling cellular biochemistry, adenosine triphosphate (ATP), the most abundant NTP in...
ORGANISM(S): Homo sapiens (Human) 
2019-03-11 | PXD012356 | Pride
Atp Jurkat Spp 
ProteomicsProteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP - TPP datasets
Nucleotide triphosphates (NTPs) regulate numerous biochemical processes in cells as (co-)substrates, allosteric modulators, biosynthetic precursors, and signaling molecules1-3. Apart from its roles as energy source fueling cellular biochemistry, adenosine triphosphate (ATP), the most abundant NTP in...
ORGANISM(S): Homo sapiens (Human) 
2019-03-11 | PXD012423 | Pride
Atp Jurkat Tpp 
ProteomicsProteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP - effect of Mg dataset
Nucleotide triphosphates (NTPs) regulate numerous biochemical processes in cells as (co-)substrates, allosteric modulators, biosynthetic precursors, and signaling molecules1-3. Apart from its roles as energy source fueling cellular biochemistry, adenosine triphosphate (ATP), the most abundant NTP in...
ORGANISM(S): Homo sapiens (Human) 
2019-03-11 | PXD012745 | Pride
Atp Jurkat Spp 
ProteomicsThe small molecule lipoamide modulates stress granule condensation with beneficial outcomes for familial amyotrophic lateral sclerosis models
We have evaluate the in-situ targets of lipoamide - a compund that causes alteration of the fluidity of in-vito FUS condensate and dissolves stress granules in cells - in Hela cells stressed with 1 mM arsenate. We have used quantitative proteomics based thermal proteome profiling to characterise the...
ORGANISM(S): Homo sapiens (Human) 
2025-05-09 | PXD039501 | Pride
Target engagement Thermal proteome profiling Als Biomolecular condensates Lipoamide 
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