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ProteomicsA proteogenomics study using the Seer Proteograph platform
In recent years, the development of molecular clocks has provided avenues for estimation of biological age. Traditionally, methylation-based epigenetic clocks have been the focus of age predictor developments, however individual proteomics, transcriptomics, and ATAC-Seq have provided avenues for oth...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD048709 | Pride
Gwas Proteomics Mass spectrometry Genome-wide association studies Protein quantitative trait loci Pqtl Proteograph™ workflow 
ProteomicsHuman Bone Marrow Interstitial Fluid Plasma Cell Dyscrasias LC-MSMS
Bone Marrow Interstital Fluid from 120 patients with various plasma cell dyscrasias were assessed using Seer's Proteograph XT platform and an LC-MS system. For each sample, two MS injections were performed, one for each nanoparticle incubation used in the Proteograph XT.
ORGANISM(S): Homo sapiens (Human) 
2025-10-21 | PXD059339 | Pride
Lc-msms Bone marrow interstitial fluid Multiple myeloma 
UnknownA genome-wide association study of mass spectrometry proteomics using the Seer Proteograph platform.
Not available
S-EPMC11160678 | biostudies-literature
ProteomicsImpact of Sample Preparation Strategies on The Quantitative Accuracy of Low-Abundance Serum Proteins in Shotgun Proteomics
Serum proteomics plays a crucial role in biomarker discovery and disease research, yet the selection of an optimal sample preparation method remains challenging. Evaluating the accuracy of protein quantitation is of major importance and a vital part of a benchmarking study in proteomics, since clini...
ORGANISM(S): Homo sapiens (Human) 
2025-09-15 | PXD062785 | Pride
Reproducibility Quantitative accuracy Serum proteomics Depth of coverage 
ProteomicsMultiplexed Nanoparticle Protein Corona Enables Accurate and Precise Deep Plasma Proteomics
The Proteograph Product Suite, a multiplexed nanoparticle (NP) protein corona-based proteomics workflow, substantially improves the depth of detection of proteins by mass spectrometry (MS) by compressing the dynamic range of protein abundances. Here, we explore the quantitative performance of the Pr...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2025-10-22 | PXD066813 | Pride
Lc-ms Plasma proteomics Precision Nanoparticle Protein corona Quantification accuracy Proteograph product suite 
ProteomicsMultiplexed Nanoparticle Protein Corona Enables Accurate and Precise Deep Plasma Proteomics
The Proteograph Product Suite, a multiplexed nanoparticle (NP) protein corona-based proteomics workflow, substantially improves the depth of detection of proteins by mass spectrometry (MS) by compressing the dynamic range of protein abundances. Here, we explore the quantitative performance of the Pr...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2025-10-22 | PXD066700 | Pride
Lc-ms Plasma proteomics Precision Nanoparticle Protein corona Quantification accuracy Proteograph product suite 
ProteomicsMultiplexed Nanoparticle Protein Corona Enables Accurate and Precise Deep Plasma Proteomics
The Proteograph Product Suite, a multiplexed nanoparticle (NP) protein corona-based proteomics workflow, substantially improves the depth of detection of proteins by mass spectrometry (MS) by compressing the dynamic range of protein abundances. Here, we explore the quantitative performance of the Pr...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2025-10-22 | PXD066817 | Pride
Lc-ms Plasma proteomics Precision Nanoparticle Protein corona Quantification accuracy Proteograph product suite 
ProteomicsCross-Platform Evaluation Reveals Sample Preparation-Driven Biological Biases despite Advances in Mass Spectrometry Performance in Serum Proteomics
Advances in mass spectrometry (MS) instrumentation and protein extraction technologies are reshaping proteomics; however, whether improved analytical performance alters the biological information accessible from different sample preparation strategies remains unclear. Here, we performed a cross-plat...
ORGANISM(S): Homo sapiens (Human) 
2026-09-11 | PXD078563 | Pride
Serum proteomics Reproducibility Quantitative accuracy Depth of proteome Orbitrap exploris 480 Bruker tims-tof ht Biomarker discovery 
ProteomicsComparison of deep plasma proteome enrichment methods
Plasma is a complex biological fluid containing extracellular vesicles (EVs), residual platelets, and soluble proteins, all of which can serve as biomarkers for pathological conditions. While conventional plasma proteomics typically identifies hundreds of proteins, recent enrichment strategies have ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-17 | PXD063673 | Pride
Enrichplus Proteograph Magnet Timstof Enrichment Plasma Evs Lc-ms/ms 
ProteomicsMultiplexed Nanoparticle Protein Corona Enables Accurate and Precise Deep Plasma Proteomics
The Proteograph Product Suite, a multiplexed nanoparticle (NP) protein corona-based proteomics workflow, substantially improves the depth of detection of proteins by mass spectrometry (MS) by compressing the dynamic range of protein abundances. Here, we explore the quantitative performance of the Pr...
ORGANISM(S): Homo sapiens (Human) 
2025-10-22 | PXD066851 | Pride
Lc-ms Plasma proteomics Precision Nanoparticle Protein corona Quantification accuracy Proteograph product suite 
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