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ProteomicsProteome analysis of testis from infertile protein C inhibitor deficient mice reveals predominant changes in serpin processing and prostaglandin metabolism
Serine protease inhibitors have therapeutic potential in a variety of pathogenic processes, ranging from thrombosis, altered immune response to liver cirrhosis. To investigate the physiological effects of protein C inhibitor (PCI, serpinA5) this gene was inactivated in a mouse model with the resulti...
ORGANISM(S): Mus musculus (Mouse) 
2015-12-07 | PXD002944 | Pride
Mouse Proteomics Serpin 
ProteomicsIntermittent Fasting Drives Metabolic Reprogramming Through Tissue-Specific and Shared Molecular Adaptations
Intermittent fasting (IF) has emerged as a powerful dietary intervention with significant metabolic benefits, yet the tissue-specific molecular mechanisms underlying these effects remain poorly understood. In this study, we employed a multi-omics approach, integrating proteomics and transcriptomics,...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-18 | PXD063124 | Pride
Intermittent fasting Bioinformatics Metabolic reprogramming Transcriptomics Serpina1c Proteomics 
UnknownPhosphorylation regulation of cardiac proteins in Babesia microti infected mice in an effort to restore heart function.
Not available
S-EPMC8935697 | biostudies-literature
TranscriptomicsTranscription profiling of mouse embyronic stem cells cultured with PI3-K signalling inhibitor LY294002 to identify PI3K-target genes
This experiment is part of the FunGenES project (FunGenES - Functional Genomics in Embryonic Stem Cells partially funded by the 6th Framework Programme of the European Union, http://www.fungenes.org).The experiment was conducted at the Unyversity of Bath, Bath, UK. Aim of the experiment is the ident...
ORGANISM(S): Mus musculus 
2009-05-07 | E-TABM-673 | biostudies-arrayexpress
TranscriptomicsIntegrated genomic profiling of endometrial carcinoma
Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation Although 75% of endometrial cancers are treated at an early stage, 15% to 20% of these recur. We performed an integrated analysis of genome-wide expression and copy-number dat...
ORGANISM(S): Homo sapiens 
2009-03-23 | E-GEOD-14860 | biostudies-arrayexpress
no omics definedTranscription profiling of human KNS42 cells treated with the dual pI3-kinas/mTOR inhibitor PI-103
Sensitivity to temozolomide (TMZ) is restricted to a subset of glioblastoma patients, with the major determinant of resistance a lack of promoter methylation of the gene encoding the DNA methyltransferase MGMT, although other mechanisms are thought to be active. In a genome-wide screen of paediatric...
ORGANISM(S): Homo sapiens 
2011-01-08 | E-TABM-890 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embyronic stem cells cultured with PI3-K signalling inhibitor LY294002 for different lengths of time to identify PI3K-target genes
This experiment is part of the FunGenES project (FunGenES - Functional Genomics in Embryonic Stem Cells partially funded by the 6th Framework Programme of the European Union, http://www.fungenes.org).The experiment was conducted at the Unyversity of Bath, Bath, UK. Aim is to identify genes regulated...
ORGANISM(S): Mus musculus 
2009-05-07 | E-TABM-674 | biostudies-arrayexpress
TranscriptomicsGene expression changes upon treatment of T47D breast cancer cells with the Pan-PI3 kinase inhibitor GDC-0941
We sought to determine genes whose expression changed upon treatment with a selective inhibitor of class I PI3 kinase. Total of 6 samples: cells were treated with GDC-0941 at a concentration of 1mM for 6 hours (3 replicates) and control (3 replicates)
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-20719 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human paediatric acute lymphoblastic leukaemia
We addressed the clinical significance and mechanisms behind in vitro cellular responses to ionising radiation (IR)-induced DNA double strand breaks in 74 paediatric ALL patients. We found an apoptosis-resistant response in 36% of patients and an apoptosis-sensitive response in the remaining 64% of ...
ORGANISM(S): Homo sapiens 
2008-11-13 | E-GEOD-13280 | biostudies-arrayexpress
ProteomicsPhosphorylation regulation of cardiac proteins in Babesia microti infected mice in an effort to restore heart function
The dynamic changes of all proteins in the heart of mice infected with Babesia were studied by using DIA quantitative proteomics technology, and the regulation strategy of proteins in the heart of mice infected with Babesia was discussed.
ORGANISM(S): Mus Musculus 
2021-11-01 | PXD029452 |
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