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TranscriptomicsGene expression changes associated with progression of Irf8M-bM-^@M-^S/M-bM-^@M-^S CML-like disease into blast crisis after M-NM-2-catenin activation
Progression and disease relapse of chronic myeloid leukemia (CML) depends on leukemia-initiating cells (LIC) that resist treatment. Using mouse genetics, we observed that compound constitutive activation of M-NM-2-catenin and deletion of Irf8 results in progression of CML-like disease into fatal bla...
ORGANISM(S): Mus musculus 
2013-09-26 | E-GEOD-49054 | biostudies-arrayexpress
UnknownPolygenic Risk Score to Identify Subclinical Coronary Heart Disease Risk in Young Adults.
Not available
S-EPMC8530876 | biostudies-literature
ProteomicsC-BERST: Defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2
Mapping proteomic composition at distinct genomic loci and subnuclear landmarks in living cells has been a long-standing challenge. Here we report that dCas9-APEX2 Biotinylation at genomic Elements by Restricted Spatial Tagging (C-BERST) allows the unbiased mapping of proteomes near defined genomic ...
ORGANISM(S): Homo sapiens (Human) 
2018-05-07 | PXD009216 | Pride
Apex2 Biotinylation Centromere Proteomes Cas9 Subnuclear Telomere 
ProteomicsSarcoglycan interactions in murine muscle membranes
The sarcoglycan complex (SC) is part of a network that links the striated muscle cytoskeleton to the basal lamina across the sarcolemma. The SC coordinates changes in phosphorylation and Ca++-flux during mechanical deformation, and these processes are disrupted with loss-of-function mutations in gam...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-16 | PXD028584 | Pride
Muscle proteomics Immunoaffinity purification Sarcoglycan complex Shotgun proteomics Sarcolemma Limb girdle muscular dystrophy Skeletal muscle Archvillin Membrane biochemistry Protein-protein interactions 
ProteomicsGlycan shield of the ebolavirus envelope glycoprotein GP
The envelope glycoprotein GP of the ebolaviruses is essential for host cell attachment and entry. It is also the primary target of the protective and neutralizing antibody response in both natural infection and vaccination. GP is heavily glycosylated with up to 17 predicted N-linked sites, numerous ...
ORGANISM(S): Bundibugyo ebolavirus Zaire ebolavirus 
2022-08-02 | PXD031459 | Pride
Virus  ebola  glycosylation 
UnknownLow prevalence of glomerulonephritis in transplanted kidneys from deceased donors with active hepatitis C virus infection.
Not available
S-EPMC12380177 | biostudies-literature
GenomicsGenomewide occupancy of the synovial sarcoma-associated SYT-SSX2 oncoprotein in C2C12 myoblasts
Synovial sarcoma is a rare malignancy that is characterized by the presence of a chromosomal translocation t(X;18). This genetic abnormality results in the fusion of 2 transcriptional co-regulators, SYT and SSX, which have been shown to mediate transcriptional activation and repression, respectivel...
ORGANISM(S): Mus musculus 
2011-09-26 | E-GEOD-26564 | biostudies-arrayexpress
UnknownNear-Infrared Intraoperative Chemiluminescence Imaging.
Not available
S-EPMC5061038 | biostudies-literature
UnknownA genome-wide association study of heparin-induced thrombocytopenia using an electronic medical record.
Not available
S-EPMC4433536 | biostudies-literature
ProteomicsQuantitative proteomics study of Mecp2 KO versus wild type mice
Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutations in the transcriptional regulator MeCP2. RTT is characterized by having apparently normal development until 6-18 months, when a progressive decline in motor and language functions begins and breathing abnormalities and...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-02 | PXD006460 | Pride
Dia Mouse brain cortex Rett syndrome 
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