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UnknownAllogeneic T Cells That Express an Anti-CD19 Chimeric Antigen Receptor Induce Remissions of B-Cell Malignancies That Progress After Allogeneic Hematopoietic Stem-Cell Transplantation Without Causing Graft-Versus-Host Disease.
Not available
S-EPMC4872017 | biostudies-literature
ProteomicsZBTB48 is a pioneer factor regulating B-cell-specific CIITA expression
CIITA is the master regulator of MHC II genes expression and hence the adaptive immune response. CIITA expression itself is tightly regulated by three cell type-specific promoters, pI, pIII, and by pIV, and can also be induced by IFNg in non-immune cells. While key regulatory elements have been iden...
ORGANISM(S): Homo sapiens (Human) 
2024-12-22 | PXD043134 | Pride
Mhc ii Adaptive immunity B cell Zinc finger Pioneer factor Molecular switch Ciita Zbtb48 
ProteomicsZNF524 directly interacts with telomeric DNA and supports telomere integrity
Telomeres are nucleoprotein structures at the ends of linear chromosomes. In humans, they consist of TTAGGG repeats, which are bound by dedicated proteins such as the shelterin complex. This complex blocks unwanted DNA damage repair at telomeres, e.g. by suppressing non-homologous end joining (NHEJ)...
ORGANISM(S): Homo sapiens (Human) 
2023-10-21 | PXD043084 | Pride
Trf2 Genome integrity Alt Telomeres Rap1 Znf524 Osteosarcoma 
ProteomicsA novel enzyme-mediated method for covalent surface modification of extracellular vesicles to achieve targeted drug delivery
Natural extracellular vesicles (EVs) are ideal drug carriers due to their remarkable biocompatibility. Their delivery specificity can be achieved by the conjugation of targeting ligands. However, existing methods to engineer target-specific EVs are tedious or inefficient, having to compromise betwee...
ORGANISM(S): Homo sapiens (Human) 
2021-03-24 | PXD021926 | Pride
Extracellular vesicles Rbcevs Drug delivery 
ProteomicsZNF524 directly binds telomeres and supports their integrity via TRF2/RAP1
Telomeres are nucleoprotein structures at the ends of linear chromosomes. In humans, they consist of TTAGGG repeats, which are bound by dedicated proteins such as the shelterin complex. This complex consists of six proteins (TRF1, TRF2, RAP1, POT1, TPP1 and TIN2) and blocks unwanted DNA damage repai...
ORGANISM(S): Homo sapiens (Human) 
2023-10-21 | PXD024630 | Pride
Genome stability Telomeres Znf524 Bioid 
UnknownParticle-like topologies in light.
Not available
S-EPMC8608860 | biostudies-literature
UnknownInfluence of methylation and demethylation on plant uptake of emerging contaminants.
Not available
S-EPMC9988749 | biostudies-literature
UnknownThe growth of the central region by acquisition of counterrotating gas in star-forming galaxies.
Not available
S-EPMC5075802 | biostudies-literature
GenomicsOCAC OncoArray data
Germline genotype data on 56,479 ovarian cancer cases and controls
EGAD00010001192 | EGA
GenomicsThe Ovarian Cancer Association Consortium OncoArray genome-wide association study
A custom Illumina genotyping array, the OncoArray. The array includes a genome-wide backbone, comprising 230,000 SNPs tagging most common genetic variants, together with dense mapping of known susceptibility regions, rare variants from sequencing experiments, pharmacogenetic markers, and cancer-rela...
EGAS00001002305 | EGA
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