Sieber Stephan A SA

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Proteomics (49)

Organisms

Aerococcus urinae NBRC 15544 = CCUG 36881 (47)
Allexis (47)
Apostichopus japonicus (47)
Canis lupus familiaris (47)
Carya cathayensis (47)
Clostridioides difficile 630 (47)
Cyanophora paradoxa (47)
Ensifer adhaerens (47)
Enterococcus faecalis (47)
Globicatella sanguinis (47)
Histomonas meleagridis (47)
Human immunodeficiency virus 1 (47)
Listeria monocytogenes (47)
Marchantia polymorpha (47)
Methylohalobius crimeensis 10Ki (47)
Mus musculus (47)
Mycobacterium tuberculosis (47)
Ophrys garganica (47)
Ophrys sphegodes (47)
Physcomitrium patens (47)
Pseudomonas aeruginosa SJTD-1 (47)
Pseudomonas putida KT2440 (47)
Rattus norvegicus (47)
Rhizobium sp. Leaf68 (47)
Schizosaccharomyces pombe 927 (47)
Schizosaccharomyces pombe 972h- (47)
Sphingomonas sp. Leaf257 (47)
Staphylococcus aureus (47)
Homo sapiens (1)
Pseudomonas aeruginosa PAO1 (1)

Repository

pride (47)
PanoramaPublic (2)

Tissue

Cell culture (10)
Epithelial cell (5)
HeLa cell (3)
Cell suspension culture (2)
Fibroblast (2)
Permanent cell line cell (2)
T cell (2)
Brain (1)
Hepatocyte (1)
JURKAT cell (1)
Lung (1)

Disease

Acute leukemia (2)
Bacterial gastritis (1)
Bacterial infectious disease (1)
Breast cancer (1)
Disease by infectious agent (1)
Liver cancer (1)
Perrault syndrome (1)
Tuberculosis (1)

Technology Type

Mass Spectrometry (47)
Shotgun proteomics (31)
Affinity purification coupled with mass spectrometry proteomics (14)
Bottom-up proteomics (9)
Data-independent acquisition (6)
Data-dependent acquisition (5)
Top-down proteomics (4)
Affinity proteomics (3)
Chemical cross-linking coupled with mass spectrometry proteomics (3)

Publication Date

2022 (8)
2020 (6)
2019 (6)
2026 (5)
2025 (5)
2021 (4)
2023 (4)
2018 (4)
2024 (3)
2017 (3)
2016 (1)

Lab affiliation

Center for Functional Protein Assemblies (CPA), Department of Bioscience, TUM School of Natural Sciences, Technical University of Munich (TUM), Ernst-Otto-Fischer-Stra?e 8, 85748 Garching, Germany (2)
Center for Integrated Protein Science Munich (CIPSM) at the Department of Chemistry, Technische Universität München, Lichtenbergstraße 4, 85747 Garching b. München (2)
Center for Integrated Protein Science at the Department of Chemistry, Technische Universität München, Garching b. München 85747, Germany; Chair of Organic Chemistry II, Technische Universität München, Garching b. München 85747, Germany (2)
TUM School of Natural Sciences, Department Biosciences, Chair of Organic Chemistry II, Center for Functional Protein Assemblies (CPA), Technical University Munich (TUM), Ernst-Otto-Fischer Str. 8, Garching, 85748, Germany (2)
Center for Functional Protein Assemblies (CPA), Department of Chemistry, Chair of Organic Chemistry II, Technical University of Munich, 85748 Garching, Germany (1)
Center for Functional Protein Assemblies, Department of Bioscience, TUM School of Natural Sciences, Technical University of Munich, Ernst-Otto-Fischer-Straße 8, 85748 Garching, Germany. (1)
Center for Functional Protein Assemblies, TUM School of Natural Sciences, Technical University of Munich, Ernst-Otto-Fischer-Straße 8, 85748 Garching, Germany. (1)
Center for Functional Protein Assemblies, Technical University of Germany, Germany (1)
Center for Functional Protein Assemblies, Technical University of Munich, Germany (1)
Center for Integrated Protein Science Munich (CIPSM) at the Department of Chemistry, Technische Universität München, Lichtenbergstraße 4, 85747 Garching b. München ( lab head ) (1)
Centre for Functional Protein Assemblies, Technical University of Munich, Ernst-Otto-Fischer-Straße 8, D-85748 Garching, Germany. (1)
Chair of Organic Chemistry II Department of Chemistry Technical University Munich 85748 Garching (1)
Chair of Organic Chemistry II TU München Ernst-Otto-Fischer-Straße 8 D-85748 Garching Germany (1)
Chair of Organic Chemistry II, Technical University of Munich (1)
Departmen of Chemistry Chair for Organic Chemistry II Technical University Munich Lichtenbergstraße 4 85748 Garching (1)
Department of Chemistry Chair of Organic Chemistry II Technical University of Munich Germany (1)
Department of Chemistry, Chair of Organic Chemistry II, Center For Functional Protein Assemblies (CPA), Technische Universität München, Lichtenbergstraße 4, 85748 Garching, Germany (1)
Department of Chemistry, Chair of Organic Chemistry II, Center for Functional Protein Assemblies (CPA), Technical University of Munich, Ernst-Otto-Fischer Straße 8, 85748 Garching, Germany (1)
Department of Chemistry, Chair of Organic Chemistry II, Technical University of Munich, Germany (1)
Department of Chemistry, Technische Universität München, Garching bei München, Germany. (1)
Department of Chemistry, Technische Universität München, Germany (1)
Dr Stephan A. Sieber, TUM Center for Functional Protein Assemblies (CPA), Department of Chemistry and Chair of Organic Chemistry II, Technical University of Munich, Lichtenbergstraße 4, 85748 Garching, Germany. (1)
Lehrstuhl Organische Chemie II, Department of Chemistry, Technische Universität München, Lichtenbergstraße 4, 85747 Garching b. München (1)
Lehrstuhl fuer Organische Chemie II Department Chemie TU Muenchen (1)
Stephan A. Sieber, Center for Integrated Protein Science at the Department of Chemistry, Technische Universität München, Garching b. München 85747, Germany; Chair of Organic Chemistry II, Technische Universität München, Garching b. München 85747, Germany (1)
Stephan A. Sieber, Center for Integrated Protein Science at the Department of Chemistry, Technische Universitä¤t München, Garching b. München 85747, Germany; Chair of Organic Chemistry II, Technische Universität München, Garching b. München 85747, Germany (1)
TU Muenchen Center for Functional Protein Assemblies Department of Chemistry Chair for Organic Chemistry II (1)
TU Muenchen Department of Chemistry Organic Chemistry II (1)
TU Munich, Chair of Organic Chemistry II, Center for Protein Assemblies, Ernst-Otto-Fischer-Str. 8 85748 Garching (1)
TU Munich, Department of Chemistry Lichtenbergstr. 4 Garching, DE 85747 (1)

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The cytotoxic natural product vioprolide A targets nucleolar protein 14 essential for ribosome biogenesis

The cytotoxic and antifungal peptolides vioprolide A-D were discovered in 1996, however their mode-of-action has so far been unsolved. Anti-cancer effect of the most potent cytotoxic derivative vioprolide A (VioA) were evaluated, showing a prominent potency against human acute lymphoblastic leukemia...

ORGANISM(S): Homo sapiens (Human)

2020-01-13 | PXD015196 | Pride

Whole proteome and Secretome analysis of Staphylococcus aureus ClpXP mutant strains

Staphylococcus aureus represents an opportunistic pathogen which utilizes elaborate quorum sensing mechanisms to precisely control the expression and secretion of virulence factors. Previous studies indicated a role of the ClpXP proteolytic system in controlling pathogenesis. While detailed transcri...

ORGANISM(S): Bacteria Staphylococcus aureus

2021-03-12 | PXD018932 | Pride

Proteomics Staphylococcus aureus Whole proteome analysis Lc-ms/ms

NATURAL PRODUCT DERIVED IANTHELLIFORMISAMINES INHIBIT PROTEIN TRANSLATION AND BLOCK BACTERIAL FLAGELLUM ASSEMBLY

Natural products have been a great source for novel drugs especially antibiotics. Given the current antibiotic crisis, revisiting poorly characterized antibacterial natural products may reveal novel modes of action (MoA) as inspiration for drug development. Here, we selected the natural product clas...

ORGANISM(S): Escherichia coli

2026-05-25 | PXD070366 | Pride

Abpp E. coli k12 Orbitrap eclipse tribrid instrument

Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus

To combat methicillin-resistant Staphylococcus aureus (MRSA) infections novel drugs are desperately needed. From a screen, we found that the anti-cancer drug sorafenib effectively kills MRSA strains. By synthetic variation of key structural features, we identified a potent analog, PK150, exhibiting ...

ORGANISM(S): Staphylococcus aureus

2019-09-09 | PXD012946 | Pride

Full proteome Affinity-based protein profiling (afbpp) Q exactive plus Chemical proteomics Staphylococcus aureus subsp. aureus nctc 8325 Secretome Surfaceome Orbitrap fusion

A chemical proteomic analysis of illudin-interacting proteins

The illudin natural product family are fungal secondary metabolites with a characteristic spirocyclopropyl-substituted fused 6,5-bicyclic ring system. They have been extensively studied for their cytotoxicity in various tumor cell types and semisynthetic derivatives with improved therapeutic charact...

ORGANISM(S): Homo sapiens (Human)

2020-01-09 | PXD014175 | Pride

Illudins Activity based protein profiling

Degrasyn exhibits antibiotic activity against multi-resistant Staphylococcus aureus by modifying several essential cysteines

In this dataset, we investigate the targets of degrasyn in the methicillin-sensitive S. aureus strain NCTC 8325. This includes data on enrichment studies and competition studies with conventional ABPP using a degrasyn-derived probe, competition studies with residue-specific proteomics using the isoD...

ORGANISM(S): Staphylococcus aureus

2020-04-14 | PXD016413 | Pride

Chemoproteomics Antibioitcs S. aureus Isodtb-abpp

A chemical probe unravels the reactive proteome of health-associated catechols

Catechol-containing natural products are common constituents of foods, drinks, and drugs. Natural products carrying this motif are often associated with beneficial biological effects such as anticancer activity and neuroprotection. However, the molecular mode of action behind these properties is poo...

ORGANISM(S): Homo sapiens (Human)

2023-10-24 | PXD043348 | Pride

Dopamine Catechols Q exactive plus Sh-sy5y Human Hek293 Lc-ms/ms

A quantitative map of beta-lactone induced virulence regulation

Beta-lactones have recently been introduced as the first selective ClpP inhibitors that attenuate virulence of both sensitive Staphylococcus aureus and multiresistant strains (MRSA). Although previous knockout studies showed that ClpP is essential for S. aureus alpha-toxin production a link between ...

ORGANISM(S): Staphylococcus aureus

2017-02-08 | PXD004680 | Pride

Proteomics Chemical knockout S. aureus clpp Antivirulence Activity-based protein profiling

A chemical probe to monitor parkinsonism-associated protein DJ-1 in live cells

Oxidative stress is a contingent trigger of Parkinson`s disease (PD). DJ-1, a protein involved in oxidative stress sensing, gained major attention when mutations in its gene were identified in PD patients. Although the study of the corresponding protein function is still in its infancy, a crucial ox...

ORGANISM(S): Homo sapiens (Human)

2018-07-17 | PXD009444 | Pride

Human Lc-ms/ms

Pronucleotide probes reveal a diverging specificity for AMPylation vs. UMPylation of human and bacterial nucleotide transferases

AMPylation is a post-translational modification utilized by human and bacterial cells to modulate the activity and function of specific proteins. Major AMPylators such as human FICD and bacterial VopS have been studied extensively for their substrate and target scope in vitro. Recently, an AMP pronu...

ORGANISM(S): Homo sapiens (Human)

2024-02-27 | PXD045925 | Pride

Infection Ampylation Vops Umpylation Pronucleotide

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49 Results

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