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ProteomicsIn vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis
Cancer progresses through distinct stages and mouse models recapitulating traits of this progression are frequently used to explore genetic, morphological and pharmacological aspects of tumor development. To complement genomic investigations of this process, here we quantify phosphoproteomic changes...
ORGANISM(S): Mus musculus (Mouse) 
2013-03-13 | PXD000821 | Pride
Mouse Silac Phosphoproteomics Skin carcinogenesis 
TranscriptomicsAnalysis of HeLa cells after transfection with miR-1, miR-124 and miR-181.
Analysis of HeLa cells at 24 hours after transfection with wild type miR-1, miR-124, miR-181 versus control transfected HeLa cells. Results were compared to protein down-regulation at 48 hours measured by SILAC-MS. Analysis of HeLa cells at 24 hours after transfection with wild type miR-1, miR-124,...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-11968 | biostudies-arrayexpress
UnknownIdentification of disease specific pathways using in vivo SILAC proteomics in dystrophin deficient mdx mouse.
Not available
S-EPMC3650321 | biostudies-literature
ProteomicsTET1 interactome by SILAC IP-MS in mouse ESCs
TET1 maintains hypomethylation at bivalent promoters through its catalytic activity in embryonic stem cells (ESCs). However, whether and how TET1 exerts catalytic activity-independent functions in regulating bivalent genes is not well understood. Therefore, we mapped the TET1 interactome in mouse ES...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-10 | PXD033587 | Pride
Silac Ip-ms Tet1 Escs 
ProteomicsNIH 3T3 AHA p-c, SILAC p-c, inhibitor, and enrichment control experiments
We developed a pulse-chase method in where fully SILAC (heavy, medium-heavy and Light) labelled cells were pulsed with Azidohomoalanine (AHA) and then chased for different length of times. These experiments were performed with 0, 1, 2, 4, 8, 16 and 13 h of chase. Data from 3 biological replicates ar...
ORGANISM(S): Mus musculus (Mouse) 
2016-10-06 | PXD004929 | Pride
Azidohomoalanine Mouse Silac Degradation Aneuploidy 
ProteomicsComparative proteomic profiling of 3T3-L1 adipocyte differentiation using SILAC quantification
Comparative proteomic profiling of 3T3-L1 adipocyte differentiation using SILAC quantification
ORGANISM(S): Mus musculus (Mouse) 
2020-10-26 | PXD019716 | Pride
Differentiation 3t3-l1 Adipocyte Silac 
ProteomicsPlant SILAC: Stable-Isotope Labelling with Amino Acids of Arabidopsis Seedlings for Quantitative Proteomics.
Stable Isotope Labelling by Amino acids in Cell culture (SILAC) is a powerful technique for comparative quantitative proteomics, which has recently been applied to a number of different eukaryotic organisms. Inefficient incorporation of labelled amino acids in cell cultures of Arabidopsis thaliana h...
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
2016-08-15 | MSV000080043 | MassIVE
Proteomicsspint1 specific knokout in mouse pancreas islet SILAC
SPINT1 is a membrane-anchored serine protease inhibitor that modulates pericellular proteolysis. The pancreas-specific disruption of Spint1 in mice significantly decreased islet size and mass, leading to glucose intolerance, which was causally related to the down-regulation of MafA and insulin. Mech...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-01 | PXD039190 | Pride
Spint1 Silac Islet Mouse 
ProteomicsSysQuan: repurposing SILAC mice for affordable absolute quantitation of the human proteome
Relative quantitation, used by most MS-based proteomics laboratories to determine protein fold-changes, requires that samples are processed and analyzed together to enable best comparability through minimizing batch differences. This limits the detection of subtle but relevant changes in heterogeneo...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-06-16 | PXD057266 | Pride
Proteomics Silac Stable isotope Targeted proteomics Absolute quantitation 
ProteomicsSILAC labelled tendon fibroblasts
Monitoring protein abundance using Mass Spectrometry within cells is a widely used technique and commonly used. The abundance however is a static measurement with no real information about the dynamics of those proteins and so clearly missing important information. In order to get a better appreciat...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-23 | PXD036794 | Pride
Silac tendon fibroblasts turnover 
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