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ProteomicsGAK and PRKCD are positive regulators of Parkin-independent mitophagy
Mitophagy plays a key cellular role for the programmed or damage induced removal of mitochondria, however, precisely how this process is orchestrated in response to different stimuli still requires investigation. In this work we have screened for regulators of PARKIN-independent mitophagy using an s...
ORGANISM(S): Homo sapiens (Human) 
2021-09-29 | PXD022773 | Pride
Gak Dfp Prkcd Mitophagy Protein kinase c delta Cyclin g associated kinase 
Proteomics: GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics through ER-Mitochondria cholesterol transport
During autophagy, cytosolic cargo is sequestered into double-membrane vesicles called autophagosomes. The origin and identity of the membranes that form the autophagosome remain to be fully characterized. Here, we investigated the role of cholesterol in starvation-induced autophagy and identify a ro...
ORGANISM(S): Homo sapiens (Human) 
2022-10-19 | PXD027502 | Pride
Er-mitochondria Autophagy Ms Cholesterol transport 
ProteomicsSNX10 regulates the clearance of mitochondrial proteins and mitochondrial bioenergetics
We here show that SNX10 localizes to endocytic compartments in a PtdIns3P-dependent manner and that mutations in the PX domain associated with autosomal recessive osteopetrosis prevent its endosomal recruitment. We demonstrate that SNX10 regulates endosomal trafficking but also interacts with mitoch...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056720 | Pride
Mitochondrial homeostasis Autophagy Mitophagy Mitochondria Endosomes Snx10 Endocytosis 
ProteomicsStrategies to inhibit FGFR4 V550L-driven rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is a paediatric cancer driven either by a fusion protein (e.g. PAX3-FOXO1) or by mutations in key signalling molecules (e.g. RAS or FGFR4). Despite the latter giving potential for precision medicine approaches in RMS, there are no such treatments implemented in the clinic yet....
ORGANISM(S): Homo sapiens (Human) 
2022-10-19 | PXD029719 | Pride
Proteomics Rhabdomyosarcoma Fgfr4 V550l 
UnknownCHSI costing study-Challenges and solutions for cost data collection in private hospitals in India.
Not available
S-EPMC9744278 | biostudies-literature
ProteomicsInterplay between cultured human osteoblastic and skeletal muscle cells: Effects of conditioned media on glucose and fatty acid metabolism
The interplay between skeletal muscle and bone is primarily mechanical, however, biochemical crosstalk by secreted mediators has recently gained increased attention. The aim of this study was to investigate metabolic effects of conditioned medium from osteoblasts (OB-CM) on myotubes and vice versa. ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD045723 | Pride
Energy metabolism  myokines  osteoblastic cells  osteokines  primary human myotubes 
UnknownCOVISHIELD vaccine-induced thyroiditis: a case report.
Not available
S-EPMC10722757 | biostudies-literature
UnknownDevelopment of a ZnOS+C Composite as a Potential Adsorbent for the Effective Removal of Fast Green Dye from Real Wastewater.
Not available
S-EPMC10018503 | biostudies-literature
UnknownCost of Surgical Care at Public Sector District Hospitals in India: Implications for Universal Health Coverage and Publicly Financed Health Insurance Schemes.
Not available
S-EPMC9216290 | biostudies-literature
UnknownProcess evaluation of health system costing - Experience from CHSI study in India.
Not available
S-EPMC7219765 | biostudies-literature
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