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ProteomicsAcetaminophen Adducts of Rat Liver Microsomal Proteins using LC-MSMS
The metabolism of xenobiotics in the liver can give rise to reactive metabolites that may covalently bind to tissue macromolecules, such as proteins. Determination of proteins which are targeted by reactive metabolites is of importance in drug discovery and molecular toxicology. However, there are d...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-11-04 | PXD002590 | Pride
Napqi High-resolution tandem mass spectrometry Reactive metabolites Acetaminophen Rat liver microsomes Drug-induced liver injury Covalent binding 
ProteomicsTear proteome analysis by LC-MS/MS
We have analysed the tear proteome from multiple volunteers without ocular disease using untargeted LC-MS/MS with and without pre-fractionation of peptide digests. Standard LC-MS/MS was compared to results from fractionation by mixed-mode cation exchange SPE and reverse-phase HPLC fractionation. The...
ORGANISM(S): Homo sapiens (Human) 
2023-09-01 | PXD041752 | Pride
Tear proteome Data-dependent acquisition Proteomics Lc-ms/ms 
ProteomicsRat Liver Microsomes by 2D-LC-MS/MS
Rat liver microsomes were analysed using offline strong cation exchange fractionation followed by reverse-phase chromatography coupled to quadrupole-time-of-flight high-resolution mass spectrometry using trypsin and pepsin parallel digestions. MS/MS files were searched against the UniProt protein da...
ORGANISM(S): Rattus norvegicus (Rat) 
2013-02-19 | PXD000128 | Pride
Rat Strong cation exchange Microsomes Pepsin Liver Trypsin Qqtof 
ProteomicsInvestigating byssogenesis with proteomic analysis of byssus, foot and mantle in Mytilus mussels by LC-MS/MS
Mussels synthesize an interesting class of biological materials with unique properties to adhere onto virtually any solid surface. Inter- and cross-species analyses have revealed that mussel byssus fabrication is influenced by environmental factors. In this study, proteins expressed specifically bys...
ORGANISM(S): Mytilus edulis (Blue mussel) Mytilus californianus 
2020-09-17 | PXD021023 | Pride
Mussel Byssus Bottom-up proteomics Foot Lc-ms/ms 
ProteomicsProtein Targets of Acetaminophen Covalent Binding in Rat and Mouse Liver Studied by LC-MS/MS
Acetaminophen (N-acetyl-p-aminophenol; APAP) is a mild analgesic and antipyretic used commonly worldwide. Although APAP is considered a safe and effective over-the-counter medication, it is also the leading cause of drug-induced acute liver failure. Its hepatotoxicity has been linked to the covalent...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2022-02-17 | PXD027674 | Pride
Covalent binding Reactive metabolite Napqi Acetaminophen Rat Liver Mouse 
ProteomicsProteomic Analysis of Rat Liver S9 Fraction by 2D-LC-MSMS
Liver plays a crucial role in numerous metabolic processes and therefore is the primary target of study in drug discovery and molecular toxicology. Devising an appropriate analytical strategy for an efficient analysis of the liver samples has been a major concern in proteomics. The aim of this study...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-03-26 | PXD000717 | Pride
2d-lc-msms Tripletof Proteinpilot Rat liver s9 fraction 
ProteomicsProteomic Analysis of Rat Liver Microsomes by 2D-LC-MSMS
Liver plays a crucial role in numerous metabolic processes and therefore is the primary target of study in drug discovery and molecular toxicology. Devising an appropriate analytical strategy for an efficient analysis of the liver samples has been a major concern in proteomics. The aim of this study...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-03-26 | PXD000720 | Pride
2d-lc-msms Tripletof Rat liver microsomes Proteinpilot 
ProteomicsProteomic Analysis of Human Liver Microsomes by 2D-LC-MSMS
Liver plays a crucial role in numerous metabolic processes and therefore is the primary target of study in drug discovery and molecular toxicology. Devising an appropriate analytical strategy for an efficient analysis of the liver samples has been a major concern in proteomics. The aim of this study...
ORGANISM(S): Homo sapiens (Human) 
2015-03-26 | PXD000721 | Pride
2d-lc-msms Tripletof Proteinpilot Human liver microsomes 
ProteomicsProteomic Analysis of Human Liver S9 Fraction by 2D-LC-MSMS
Liver plays a crucial role in numerous metabolic processes and therefore is the primary target of study in drug discovery and molecular toxicology. Devising an appropriate analytical strategy for an efficient analysis of the liver samples has been a major concern in proteomics. The aim of this study...
ORGANISM(S): Homo sapiens (Human) 
2015-03-26 | PXD000734 | Pride
Human liver s9 fraction 2d-lc-msms Tripletof Proteinpilot 
ProteomicsProteomic Analysis of Mouse Liver Microsomes by 2D-LC-MSMS
Liver plays a crucial role in numerous metabolic processes and therefore is the primary target of study in drug discovery and molecular toxicology. Devising an appropriate analytical strategy for an efficient analysis of the liver samples has been a major concern in proteomics. The aim of this study...
ORGANISM(S): Mus musculus (Mouse) 
2015-03-26 | PXD000731 | Pride
Mouse liver microsomes 2d-lc-msms Tripletof Proteinpilot 
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