Sort   by:  
 Page size 
ProteomicsMelanoma spliced and linear HLA-I peptides
In this project we have identifed and linear and spliced HLA-I bound peptides to LM-MEl-44, 53 and 33 cell lines in two different condition, treated and not treated with interferone gamma.
ORGANISM(S): Homo sapiens (Human) 
2020-09-25 | PXD014397 | Pride
Spliced peptides Melanoma Hla peptides 
ProteomicsEstimating the Contribution of Proteasomal Spliced Peptides to the HLA-I Ligandome
Spliced peptides are short protein fragments spliced together in the proteasome by peptide bond formation. True estimation of the contribution of proteasome-spliced peptides (PSPs) to the global Human Leukocyte Antigen (HLA) ligandome is critical. A recent study suggested that PSPs contribute up to ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-11-13 | MSV000086452 | MassIVE
ProteomicsEstimating the Contribution of Proteasomal Spliced Peptides to the HLA-I Ligandome
Spliced peptides are short protein fragments spliced together in the proteasome by peptide bond formation. True estimation of the contribution of proteasome-spliced peptides (PSPs) to the global Human Leukocyte Antigen (HLA) ligandome is critical. A recent study suggested that PSPs contribute up to ...
ORGANISM(S): Homo sapiens (Human) 
2018-09-03 | PXD010793 | Pride
Lc-msms Immunopeptidomics Proteasomal splicing Hla-i peptides 
ProteomicsIdentification of spliced peptides in pancreatic islets uncovers errors leading to false assignments
Spliced peptides have been identified in the class I major histocompatibility complex (MHC) peptidomes of several tumors and have emerged as novel autoantigens that can stimulate highly specific T cells. A special class of spliced peptides, hybrid insulin peptides (HIPs), bound to histocompatibility...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-02-11 | PXD019819 | Pride
Mhc-i peptidome Crinosomes 
ProteomicsDatabase search engines and target database features impinge upon the identification of post-translationally cis-spliced peptides in HLA class I immunopeptidomes
Unconventional epitopes presented by HLA class I complexes are emerging targets for T cell targeted immunotherapies. Their identification by mass spectrometry required development of novel methods to cope with the large number of theoretical candidates. Methods to identify post-translationally splic...
ORGANISM(S): Homo sapiens (Human) 
2022-04-06 | PXD031709 | Pride
K562 cell line Mass spectrometry Peptide splicing Immunopeptidome Hla-i Cis-spliced peptides 
ProteomicsKRAS G12V spliced neoepitope is produced by proteasomes
This dataset contains further evidence that the HLA-A*02:01+ KRAS G12V+ spliced neoepitope we previously identified (Mishto et al., Front. Immunol. 2019) is produced by proteasomes in various experimental conditions
ORGANISM(S): Homo sapiens (Human) 
2022-09-05 | PXD024528 | Pride
Mass spectrometry Epitope discovery Peptide splicing Proteasome Cis-spliced peptides Kras 
GenomicsLarge-Scale Immuno-Peptidome Analysis Reveals Recurrent Post-Translational Splicing of Cancer and Immune-Associated Genes
Post-translational spliced peptides
PRJEB53723 | ENA
ProteomicsDigging deeper into the HLA peptidome – Characterization of the post-translationally modified peptides
Peptides displayed by MHC molecules on a cell’s surface, referred to as its immunopeptidome, play an important role in the adaptive the immune response. Antigen processing for MHC class I presentation is a ubiquitous pathway present in all nucleated cells which generate and present peptides of both ...
ORGANISM(S): Homo sapiens (Human) 
2021-06-07 | PXD024562 | Pride
Spliced peptides Immunopeptidome Post-translational modifications Mhc class i Mhc binding motifs 
ProteomicsSPI-ART and the features of cis-spliced peptides in HLA class I immunopeptidomes
The identification of peptides presented by HLA class I molecules to CD8+ T cells – i.e. the HLA-I immunopeptidome - is a useful tool to fish epitopes suitable for vaccinations and immunotherapies against cancer, infection and autoimmunity. These peptides are mainly generated by proteasomes through ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD025346 | Pride
K562 cell line Mass spectrometry Peptide splicing Immunopeptidome Hla-i Cis-spliced peptides 
ProteomicsTrans-splicing of class I HLA bound peptides diversifies the immunopeptidome
The diversity of peptides displayed by class I HLA plays an essential role in T cell immunity. The peptide repertoire is extended by various post-translational modifications, including cis-splicing of peptides from the same protein. Here, we have applied a novel bioinformatic workflow and demonstrat...
ORGANISM(S): Homo sapiens (Human) 
2021-12-06 | PXD017922 | Pride
Hla Post-translational modification Mass spectrometry Immunopeptidome Proteasome Spliced peptides 
Sort   by:  
 Page size