Sort   by:  
 Page size 
TranscriptomicsGenome-wide quantitative enhancer activity maps identified by STARR-seq
Genomic enhancers are important regulators of gene expression, but their identification is a challenge and methods depend on indirect measures of activity. We developed a method termed STARR-seq to directly and quantitatively assess enhancer activity for millions of candidates from arbitrary sources...
ORGANISM(S): Homo sapiens 
2013-01-17 | E-GEOD-40739 | biostudies-arrayexpress
TranscriptomicsQuantitative genome-wide enhancer activity maps for five Drosophila species show functional enhancer conservation and turnover during cis-regulatory evolution
Phenotypic differences between closely related species are thought to arise primarily from changes in gene expression due to mutations in cis-regulatory sequences (enhancers). However, it has remained unclear, how frequently mutations alter enhancer activity or create functional enhancers de novo. H...
ORGANISM(S): Drosophila willistoni 
2014-04-28 | E-GEOD-48251 | biostudies-arrayexpress
TranscriptomicsHormone-responsive enhancer-activity maps reveal predictive motifs, indirect repression, and targeting of closed chromatin
Steroid hormones act as important developmental switches and their nuclear receptors regulate many genes. However, few hormone-dependent enhancers have been characterized and important aspects of their sequence architecture, cell type-specific activating and repressing functions, or the regulatory r...
ORGANISM(S): Drosophila melanogaster 
2014-03-27 | E-GEOD-47691 | biostudies-arrayexpress
ProteomicsAltered microbiota-host mutualism and bloom of Atopobium define severe pediatric Crohn's disease
Microbial dysbiosis has been identified in adult inflammatory bowel disease (IBD) patients. However, microbial composition and functional interplay between host genetics and microorganisms in early IBD onset remain poorly defined. Here, we identified and demonstrated the causal effect of Atopobium ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD000690 | Pride
Ibd Colon 
ProteomicsAscending colon biopsies from pediatric patients
We sought to identify proteins that enable differentiation between CD and UC in children with new onset IBD. Mucosal biopsies were obtained from children undergoing baseline diagnostic endoscopy prior to therapeutic interventions. Using a super-stable isotope labeling with amino acids in cell cultur...
ORGANISM(S): Homo sapiens (Human) 
2018-11-06 | PXD005086 | Pride
Colon Lcmsms 
ProteomicsAssociations between cellular energy and pediatric inflammatory bowel disease patient response to treatment
Crohn’s disease (CD) and ulcerative colitis are chronic inflammatory bowel diseases (IBD) of which the etiology and pathogenesis are not completely understood. In paediatric patients, the disease tends to be more severe and aggressive then in adults. Here, we perform a proteomic approach on ascendin...
ORGANISM(S): Homo sapiens (Human) 
2021-08-26 | PXD024229 | Pride
Inflammatory bowel disease Proteomics Pediatric 
ProteomicsHuman colon aspirate proteins analyzed by LC-MSMS
Colonic aspirates were collected at diagnostic colonoscopy from inflammatory bowel disease (IBD) and control, treatment-naive children. The colonic mucosal-luminal interface (MLI) proteomes were analyzed for 18 control and 42 IBD patients by liquid-chromatography mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2018-03-19 | PXD006383 | Pride
Human Lc-msms Colon aspirates 
UnknownOutcomes of eyes with lesions composed of >50% blood in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT).
Not available
S-EPMC4306628 | biostudies-literature
UnknownOutcomes in Eyes with Retinal Angiomatous Proliferation in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT).
Not available
S-EPMC4766028 | biostudies-literature
UnknownA randomized trial comparing intravitreal triamcinolone acetonide and focal/grid photocoagulation for diabetic macular edema.
Not available
S-EPMC2748264 | biostudies-literature
Sort   by:  
 Page size