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ProteomicsFunction of CK2 selectively affects the endoplasmic reticulum and the Golgi apparatus in mTOR-mediated autophagy induction.
Selective autophagy of the endoplasmic reticulum, known as ER-phagy, is essential to maintain ER homeostasis. We recently showed that members of the autophagy receptor family FAM134 are regulated by phosphorylation-dependent ubiquitination. In an unbiased screen we had identified several kinases dow...
ORGANISM(S): Homo sapiens (Human) 
2025-03-07 | PXD049341 | Pride
Human Multiplexed Lc-ms Tmtpro 18plex Gprc Compounds 
ProteomicsThe function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways.
Selective autophagy of the endoplasmic reticulum (ER), known as ER-phagy, is an important regulator of ER remodeling and is critical to maintaining cellular homeostasis during environmental changes. We recently showed that members of the FAM134 family play a role during stress-induced ER-phagy. How...
ORGANISM(S): Homo sapiens (Human) 
2023-11-16 | PXD043003 | Pride
Ck2 Er homeostasis Lysosomal degradation Er remodeling Er fragmentation Chek1 Atr Selective autophagy Atm Ubiquitination. Stress response Fam134b Fam134c Endoplasmic reticulum Mtor 
UnknownFrailty Trajectories Preceding Dementia in the US and UK.
Not available
S-EPMC11555573 | biostudies-literature
TranscriptomicsAnalyzing synergistic and non-synergistic interactions in signalling pathways using Boolean Nested Effect Models
Understanding the structure and interplay of cellular signalling pathways is one of the great challenges in molecular biology. Boolean Networks can infer signalling networks from observations of protein activation. In situations where it is difficult to assess protein activation directly, Nested Eff...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-68761 | biostudies-arrayexpress
UnknownRole of FAM134 paralogues in endoplasmic reticulum remodeling, ER-phagy and Collagen quality control
Not available
S-SCDT-EMBOR-2020-52289-T | biostudies-other
UnknownAssociation of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19.
Not available
S-EPMC10219675 | biostudies-literature
UnknownEffect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance: A Randomized Clinical Trial.
Not available
S-EPMC6143100 | biostudies-literature
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