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ProteomicsThe Parkinson’s disease kinase LRRK2 impairs release sites of vulnerable dopamine axons -striatal synaptosomes phosphoproteomic study
We and others previously reported that knock-in mice expressing the pathogenic hyperactive Lrrk2G2019S mutation, exhibit deficits in dopamine release within the striatum. To investigate the underlying molecular mechanisms, we conducted quantitative phosphoproteomic Liquid Chromatography-Mass Spectro...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-19 | PXD065006 | Pride
Lc-ms Lrrk2 Striatal synaptosomes 
ProteomicsSynaptosome proteome IGF2 enhancer knockout mice
We identified an enhancer element near IGF2 locus that is possibly involved with dopamine function and schizophrenia. A knockout mouse was generated for the enhancer element in the IGF2 locus. We then characterized the striatal synaptosomes ( i.e. biological fraction representing pre- post synaptic ...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-31 | PXD012786 | Pride
Dopamine Schizophrenia Striatum Synaptosome Igf2 
UnknownLeucine-rich repeat kinase 2 (LRRK2) inhibitors differentially modulate glutamate release and Serine935 LRRK2 phosphorylation in striatal and cerebrocortical synaptosomes.
Not available
S-EPMC6536420 | biostudies-literature
ProteomicsProteomics quantification of striatal fraction from DAT-KO and WT rats
The study aimed to find out quantitative changes at the protein level in the total membrane fraction enriched in synaptosomes and mitochondria upon the absence of the dopamine transporter in rat brain. Therefore, the brain of male rats (Wister Han) DAT-wildtype and DAT-knockout animals, were dissect...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-05-19 | PXD028157 | Pride
Lc-msms Dat-ko Knockout Striatum Rat Brain Dat Proteomics Dopamine transporter 
ProteomicsProteome of R1441C and G2019S LRRK2 knock in mice after striatal motor learning task
LRRK2 mutations are associated with both familial and sporadic forms of Parkinson’s disease (PD). Convergent evidence suggests that LRRK2 plays critical roles in regulating striatal function. Here, by using knock-in mouse lines that express the two most common LRRK2 pathogenic mutations—G2019S and R...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-15 | PXD037003 | Pride
Mouse Brain Striatum Lc-ms/ms 
UnknownPharmacological characterization of a high-affinity p-tyramine transporter in rat brain synaptosomes.
Not available
S-EPMC5128819 | biostudies-literature
UnknownFlow cytometry analysis of synaptosomes from post-mortem human brain reveals changes specific to Lewy body and Alzheimer's disease.
Not available
S-EPMC4184945 | biostudies-literature
UnknownCryo-correlative light and electron tomography of dopaminergic axonal varicosities reveals non-synaptic modulation of cortico-striatal synapses.
Not available
S-EPMC12749485 | biostudies-literature
ProteomicsProteome of mouse striatal dopamine synaptosomes purified by fluorescence sorting
Dopamine transmission is a monoaminergic system involved in reward processing and motor control. Volume transmission is thought to be the main mechanism by which monoamines modulate effector transmission though synaptic structures are scarcely described. In the present work we aimed to unravel the c...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD027534 | Pride
Synapse Dopamine Striatum Fass Synaptosome Mouse Proteome 
UnknownReal-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models.
Not available
S-EPMC4829692 | biostudies-literature
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