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ProteomicsThe mitochondrial acyl-carrier protein interaction network highlights important roles for LYRM family members in complex I and mitoribosome assembly
NDUFAB1 is the mitochondrial acyl carrier protein (ACP) essential for cell viability. Through its pantetheine-4’-phosphate post-translational modification, NDUFAB1 interacts with members of the leucine-tyrosine-arginine motif (LYRM) protein family. Although many LYRM proteins have been well describe...
ORGANISM(S): Homo sapiens (Human) 
2019-10-31 | PXD013706 | Pride
Ap-ms Lyr motif Topographical heatmap Lc-ms Mitochondria Mitoribosome Ndufab1 Respirastory chain 
ProteomicsDissecting the Roles of Mitochondrial Complex I Intermediate Assembly (MCIA) Complex Factors in the Biogenesis of Complex I
Mitochondrial Complex I harbors 7 mitochondrial and 38 nuclear-encoded subunits. Its biogenesis requires the assembly and integration of distinct intermediate modules, mediated by numerous assembly factors. The Mitochondrial Complex I Intermediate Assembly (MCIA) complex, containing assembly factors...
ORGANISM(S): Homo sapiens (Human) 
2020-04-22 | PXD018075 | Pride
Assembly factors Mitochondria Nadh-ubiquinone dehydrogenase Mcia complex Complex i Oxidative phosphorylation 
ProteomicsAbnormalities of mitochondrial dynamics and bioenergetics in neuronal cells from CDKL5 deficiency disorder
CDKL5 deficiency disorder (CDD) is a rare neurodevelopmental disorder caused by pathogenic variants in the Cyclin-dependent kinase-like 5 (CDKL5) gene, resulting in dysfunctional CDKL5 protein. It predominantly affects females and causes seizures in the first few months of life, ultimately resulting...
ORGANISM(S): Homo sapiens (Human) 
2025-04-28 | PXD063372 | Pride
Cdkl5  cdkl5 deficiency disorder  induced pluripotent stem cell  mitochondria  oxidative phosphorylation  proteomics. 
ProteomicsMitochondrial microproteins link metabolic cues to respiratory chain biogenesis
Electron transport chain (ETC) biogenesis is tightly coupled to energy levels and availability of ETC subunits. Coenzyme Q: cytochrome c oxidoreductase (complex III or CIII) occupies a central position in the ETC, receiving electrons from diverse fuel sources to control the ubiquinol:ubiquinone (CoQ...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-25 | PXD030258 | Pride
Metabolism Sep Mitochondria Oxphos Micropeptides 
ProteomicsIntegrated multi-omics for rapid rare disease diagnosis on a national scale
The Australian Acute Care Genomics program provides ultra-rapid diagnostic testing to critically ill infants and children with suspected genetic conditions. Over two years, we performed whole genome sequencing (WGS) in 290 families, with average time to result of 2.9 days, and diagnostic yield of 47...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042001 | Pride
Proteomics Genomics Intensive care Transcriptomics 
UnknownFactors associated with D-dimer levels in HIV-infected individuals.
Not available
S-EPMC3953205 | biostudies-literature
ProteomicsProteomic analysis of integrin activation-state-dependent adhesion complexes
Proteomic analysis of integrin activation-state-dependent adhesion complexes. Adhesion complexes were isolated from K562 cells using activation-state-specific monoclonal antibodies coupled to magnetic beads.Tandem mass spectra were extracted using extract_msn (Thermo Fisher Scientific) executed in M...
ORGANISM(S): Homo sapiens (Human) 
2015-01-26 | PXD000155 | Pride
Human K562 Adhesion complex Integrin Activation state Ms Proteomics 
MetabolomicsThe effect of changing haylages of differing chemical composition on the equid metabonome
Rapid changes between feeds can cause dysbiosis and colic. The metabolic consequences of changing between haylages is currently unknown. Objectives Characterise urinary and faecal metabonomics in ponies transitioned between haylages varying in botanical composition and physiological age and to deter...
2026-09-29 | MTBLS15865 | MetaboLights
UnknownDevelopment and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study.
Not available
S-EPMC4380415 | biostudies-literature
UnknownMitochondria-hubs for regulating cellular biochemistry: emerging concepts and networks.
Not available
S-EPMC6731593 | biostudies-literature
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