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ProteomicsTissue specific protein-protein associations prioritize candidate disease associated genes
Proteins that interact together participate in the same cellular process and influence the same organismal traits. Despite the progress in mapping protein interactions we lack knowledge of how these change across tissues. Due to coordinated (post)transcriptional control, protein complex members have...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-05-17 | PXD049084 | Pride
Synapse synaptosome sec 
ProteomicsStructural and functional characterization of the IgSF21-Neurexin2α complex and its related signaling pathways in the regulation of inhibitory synapse organization
The prevailing model behind synapse development and specificity is that a multitude of adhesion molecules engage in transsynaptic interactions to induce pre- and post-synaptic assembly. How these extracellular interactions translate into intracellular signal transduction for synaptic assembly remain...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-04 | PXD048927 | Pride
C-jun n-terminal kinase Gabaergic synapse Src kinase Camkii kinase Neurexin2α Signal transduction Igsf21 Neuroligin2 
ProteomicsNeuroinflammatory Stress Preferentially Impacts Synaptic MAPK Signaling and Mitochondria in Excitatory Neurons
In this study, we have applied cell type-specific in vivo biotinylation of proteins (CIBOP) to label Camk2a excitatory neuronal proteomes, and imposed differential centrifugation to prepare synaptosome-enriched fractions, followed by proteomic analysis of biotinylated neuronal proteins. This approac...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-13 | PXD068874 | Pride
Mitochondria Excitatory neuron Neuroinflammation Synapse vulnerability Alzheimer's disease Cognitive resilience Mapk signaling Native-state proteomics Synaptosome 
TranscriptomicsCircadian and Sleep regulation of synaptic RNA
Circadian rhythms are present across almost all species and affect several physiological and behavioral aspects of living organisms. The evolutionary advantage conferred by these rhythms could be their anticipatory properties. In the nervous system, anticipation is particularly interesting due to th...
ORGANISM(S): Mus musculus 
2019-02-28 | E-MTAB-7347 | biostudies-arrayexpress
ProteomicsComparative hippocampal synaptic proteomes of rodents and primates: differences in neuroplasticity-related proteins
Key to the human brain’s unique capacities are a myriad of neural cell types, specialized molecular expression signatures, and complex patterns of neuronal connectivity. Neurons in the human brain communicate via well over a quadrillion synapses. Their specific contribution might be key to the dynam...
ORGANISM(S): marmosets Homo sapiens (Human) Mus musculus (Mouse) Rattus norvegicus (Rat) 
2018-10-22 | PXD009251 | Pride
Synapse Species Proteomics Rat Marmoset Human Synaptosome Mouse Swath 
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