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TranscriptomicsSynaptosomal microRNAs and Alzheimer's disease
Purpose of our study is to determine the status of synaptosomal microRNAs in Alzheimer's disease and their roles in Alzheimer's progression.
ORGANISM(S): Homo sapiens 
2022-08-01 | E-MTAB-11983 | biostudies-arrayexpress
GenomicsTranscriptome analysis of striatal synaptosome and synaptosomal polyribosome of WT and Shank3 TG mice
Transcriptome analysis of striatal synaptosome and synaptosomal polyribosome of WT and Shank3 TG mice
PRJNA686431 | ENA
UnknownPreparation of purified perikaryal and synaptosomal mitochondrial fractions from relatively small hypothalamic brain samples.
Not available
S-EPMC4887559 | biostudies-literature
ProteomicsRepeated hypoglycemia in diabetic mice induce hypothalamic mitochondrial and synaptic activity deregulations characteristic of neurodegenerative diseases
Repeated exposures to insulin-induced hypoglycemia in diabetic patients progressively impair the counter-regulatory response (CRR) that restores normoglycemia. This defect is characterized by reduced secretion of glucagon and other counter-regulatory hormones. Evidence indicates that glucose respons...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-13 | PXD040183 | Pride
Hypothalamus Synaptosomal fractions Hypoglycemia Whole lysate Mouse Diabetes 
TranscriptomicsTranscriptome analysis of striatal synaptosome and synaptosomal polyribosome of WT and Shank3 TG mice
Shank3 protein is a core organizer of the macromolecular complex in excitatory postsynapses, and its defects cause numerous synaptopathies including autism spectrum disorders. Although Shank3 function as a postsynaptic scaffold is well established, other potential mechanisms how Shank3 broadly modul...
ORGANISM(S): Mus musculus 
2023-12-18 | GSE163528 | GEO
ProteomicsDeep and precise quantification of the mouse synaptosomal proteome reveals substantial remodeling during postnatal maturation
In order to understand the molecular underpinnings of the functional and morphological heterogeneity of synapses and their regulation during development it is essential to identify the set of proteins that form these structures. Here, we prepared cortical synaptosomal fractions from juvenile and adu...
ORGANISM(S): Mus musculus (Mouse) 
2014-08-28 | PXD000552 | Pride
Synapse proteome ageing 
UnknownAged monkey brains reveal the role of ubiquitin-conjugating enzyme UBE2N in the synaptosomal accumulation of mutant huntingtin.
Not available
S-EPMC4321442 | biostudies-literature
UnknownQuantitative Proteomics of Synaptosomal Fractions in a Rat Overexpressing Human DISC1 Gene Indicates Profound Synaptic Dysregulation in the Dorsal Striatum.
Not available
S-EPMC5808171 | biostudies-literature
ProteomicsA brain-enriched circular RNA controls excitatory neurotransmission and restricts sensitivity to aversive stimuli
The biological significance of circular RNAs remains largely unexplored due to the lack of loss-of-function animal models. In this study, we focused on circTulp4, a highly abundant circRNA that is enriched in the brain and synaptic compartments. We created a circTulp4-deficient (CD) mouse model and ...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-15 | PXD045787 | Pride
Synaptosomes Label-free proteomics Mass spectrometry Circtulp4 Phenotyping Neurophysiology Circular rna 
ProteomicsProteomics of rat overexpressing human DISC1 in the dorsal striatum
Disrupted-in-schizophrenia 1 (DISC1) is a key protein involved in behavioral processes and various mental disorders, including schizophrenia and major depression. A transgenic rat modestly overexpressing non-mutant human DISC1, modeling aberrant proteostasis of the DISC1 protein, displays behavioral...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2018-02-27 | PXD008123 | Pride
Synapse Disc1 Synaptosome Human 
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