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ProteomicsRelating human gut metagenome and metaproteome
Gut microbiome research is rapidly moving towards the functional characterization of the microbiota by means of shotgun meta-omics. Here, we selected a cohort of healthy subjects from an indigenous and monitored Sardinian population to analyze their gut microbiota using both shotgun metagenomics and...
ORGANISM(S): human gut metagenome 
2017-07-19 | PXD005780 | Pride
Gut metagenome Gut metaproteome Metaproteomics 
ProteomicsMouse_T1D_microbiota - Clostridial Butyrate Biosynthesis Enzymes Are Significantly Depleted in the Gut Microbiota of Nonobese Diabetic Mice
A metaproteomic approach was exploited to investigate microbiota protein expression in feces from Eα16 and NOD mice at 10 weeks of age (n=6 vs 6 mice)
ORGANISM(S): Mus musculus (Mouse) gut metagenome 
2018-10-15 | PXD003616 | Pride
Butyrate Gut microbiota Mouse Diabetes Metaproteomics 
ProteomicsMouse caecum vs faeces - Metaproteogenomics Reveals Taxonomic and Functional Changes between Cecal and Fecal Microbiota in Mouse
We compared the microbiota of paired mouse caecal contents and faeces by applying a multi-omic approach, including 16S rDNA sequencing, shotgun metagenomics, and shotgun metaproteomics. The aim of the study was to verify whether faecal samples are a reliable proxy for the mouse colonic luminal micro...
ORGANISM(S): mouse gut metagenome 
2017-03-31 | PXD004911 | Pride
Caecum Mouse Faeces Gut microbiota Metaproteomics 
ProteomicsThe sheep host fecal proteome - The Sarda Sheep Host Fecal Proteome
Characterization of the fecal (host) proteome in 5 Sarda sheep
ORGANISM(S): Ovis aries 
2018-01-15 | PXD006145 | Pride
Proteomics Gut Stool Sheep 
ProteomicsSequence database choice significantly affects taxonomic and functional metaproteomic results in gut microbiota studies
Elucidating the role of gut microbiota in physiological and pathological processes has recently emerged as a key research aim in life sciences. In this respect, metaproteomics (the study of the whole protein complement of a microbial community) can provide a unique contribution by revealing which fu...
ORGANISM(S): human gut metagenome 
2016-10-10 | PXD004039 | Pride
Metagenomics Bioinformatics Gut microbiota Metaproteomics 
ProteomicsEnrichment or depletion? The impact of stool pretreatment on metaproteomic characterization of the human gut microbiota
Up to date, most metaproteomic studies of the gut microbiota describe the use of stool sample pretreatment methods to enrich for microbial components. However, a specific investigation aimed at assessing if, how and to what extent this may impact on the final taxonomic and functional results is stil...
ORGANISM(S): Homo sapiens (Human) 
2015-02-25 | PXD001573 | Pride
Differential centrifugation  gut microbiome  host  metaproteomics  sample preparation 
ProteomicsSheep fecal microbiota - Diversity and functions of the sheep faecal microbiota: a multi-omic characterization
Characterization of the fecal metaproteome of dairy sheep
ORGANISM(S): Microbiota 
2017-02-22 | PXD004524 | Pride
Metaproteomics Sheep Stool 
ProteomicsCaloric restriction and rat fecal microbiota
Characterization of the fecal metaproteome in rats fed ad libitum or following a caloric restriction diet
ORGANISM(S): rat gut metagenome 
2018-10-08 | PXD007252 | Pride
Proteomics Rat Microbiome Diet Gut Stool 
ProteomicsFecal metaproteome profiles of celiac disease patients with poly-autoimmunity
Twenty-eight subjects were selected for the study from among celiac disease patients regularly followed at the Medical Clinic of the University of Sassari. Celiac disease (CD) was diagnosed according to international guidelines. Patients were divided into two groups of 14 subjects based on the prese...
ORGANISM(S): Homo sapiens (Human) human gut metagenome 
2025-10-16 | PXD069517 | Pride
Gut microbiome Celiac disease Autoimmunity Metaproteomics 
ProteomicsMetaproteomic portrait of the healthy human gut microbiota
Metaproteomic portrait of the healthy human gut microbiota. Re-analysis of existing datasets, selected based on the following inclusion criteria: human cohort including at least 5 healthy (clearly not labeled as diseased) adult (>18 years old) individuals; data derived from LC-MS/MS DDA label-free a...
ORGANISM(S): human gut metagenome 
2024-05-16 | PXD046818 | Pride
Metaproteomics Healthy human gut Functions Gut microbiota Stool 
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