Sort   by:  
 Page size 
MetabolomicsImproving Metabolite Identification with DecoID for Database-Assisted Deconvolution of Metabolomic MS/MS Spectra

Chimeric MS/MS spectra contain fragments from multiple precursor ions and therefore hinder compound identification in metabolomics. Historically, deconvolution of these chimeric spectra has been challenging and relied upon specific experimental methods that introduce variation in the ratios of pr...

2021-04-29 | MTBLS2207 | MetaboLights
MetabolomicsCorrelation-based Deconvolution (CorrDec) to generate high-quality MS2 spectra from data-independent acquisition in multi-sample studies (Urine assay)

Data-independent acquisition mass spectrometry (DIA-MS) is essential for information-rich spectral annotations in untargeted metabolomics. However, the acquired MS2 spectra are highly complex, posing significant annotation challenges. We have developed a correlation-based deconvolution (CorrDec) ...

2020-07-13 | MTBLS816 | MetaboLights
MetabolomicsCorrelation-based Deconvolution (CorrDec) to generate high quality MS2 spectra from data independent acquisition in multi-sample studies (Chemical standards assay)

Data-independent acquisition mass spectrometry (DIA-MS) is essential for information-rich spectral annotations in untargeted metabolomics. However, the acquired MS2 spectra are highly complex, posing significant annotation challenges. We have developed a correlation-based deconvolution (CorrDec) ...

2020-07-13 | MTBLS787 | MetaboLights
TranscriptomicsDeconvolution of ChIP-chip MBF occupancies reveals the temporal recruitment of Rep2 at the MBF-target genes
Deconvolution analysis using Rpb1 ChIP-chip results distinguishes the Cdc10 bindings at the Rpb1-poor loci (promoters) from those at the Rpb1-rich loci (intragenic sequences). Importantly, Res1 binding at the Rpb1-poor loci, but not at the Rpb1-rich loci, are dependent on the Cdc10 function, suggest...
ORGANISM(S): Schizosaccharomyces pombe 
2010-11-26 | E-GEOD-9912 | biostudies-arrayexpress
MetabolomicsMechanistic profiling of Bifemetstrobin against the tea anthracnose pathogen and candidate evaluation of an amine oxidase target

Tea anthracnose caused by Glomerella cingulata threatens yield and quality, while resistance to legacy fungicides highlights the need for new modes of action. We characterized the antifungal activity and mechanism of bifemetstrobin against G. cingulata by combining efficacy assays with cell ...

2026-03-13 | MTBLS13992 | MetaboLights
ProteomicsComprehensive chemical proteomics for target deconvolution of the redox active drug auranofin
Chemical proteomics encompasses novel drug target deconvolution methods in which compound modification is not required. Herein we use Thermal Proteome Profiling, Functional Identification of Target by Expression Proteomics and multiplexed redox proteomics for deconvolution of auranofin targets to ai...
ORGANISM(S): Homo sapiens (Human) 
2020-03-19 | PXD016776 | Pride
Cancer Nfkb2 Mass spectrometry Hct116 Thioredoxin reductase Expression Chordc1 Database A375 Drug Proteomics Resource Rko Chemotherapeutic Auranofin Compound 
ProteomicsChemoproteomic target deconvolution of Lipoic acid reveals Histone Deacetylases as the main targets
Here we set out to identify protein targets of Lipoic acid and Lipoamide by chemical proteomics approaches. We generated Lipoamide-based affinity matrices to pulldown target proteins and quantify them via bottom-up proteomics. Use of the same affinity matrix in dose dependent compeition assays allow...
ORGANISM(S): Homo sapiens (Human) 
2026-06-02 | PXD036810 | Pride
Lc-msms Drug target deconvolution Cancer cell lines 
ProteomicsLiP-Quant, an automated chemoproteomic approach to identify drug targets in complex proteomes, p3
LiP-Quant MS sample preparation for target deconvolution
ORGANISM(S): Homo sapiens (Human) 
2020-09-09 | PXD019902 | Pride
Small molecules Lc-ms Target deconvolution Lip-quant 
ProteomicsProteome Integral Solubility Alteration (PISA): a high-throughput proteomics assay for target deconvolution
Various agents, including drugs as well as non-molecular influences, induce alterations in the physic-chemical properties of proteins in cell lysates, living cells and organisms. These alterations can be probed by applying a stability-modifying factor, such as elevated temperature, to a varying degr...
ORGANISM(S): Homo sapiens (Human) 
2020-04-01 | PXD013182 | Pride
Protein stability Target deconvolution Tmt Thermal profiling Quantitative proteomics 
UnknownExploiting polypharmacology for drug target deconvolution.
Not available
S-EPMC3977247 | biostudies-literature
Sort   by:  
 Page size