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ProteomicsProteomics of human tau-transgenic mice reveals protein modules associated with tau pathologies
Abnormally accumulated tau protein aggregates are one of the hallmarks of dementia, including Alzheimer’s disease (AD), and are believed to play a critical role in neurodegeneration. In order to investigate proteomic alteration driven by tau aggregates, we implemented quantitative proteomics to anal...
ORGANISM(S): Mus Musculus (mouse) 
2022-07-05 | PXD031129 | JPOST Repository
ProteomicsProperties of Alzheimer’s disease brain-derived tau aggregates define tau processing by human astrocytes
The templated misfolding of tau proteins accounts for tau pathology spread in Alzheimer’s disease (AD). Post-translational modifications, including phosphorylation at specific residues, are closely linked with tau seeding ability and clinical disease progression. This study investigates the role of ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056614 | Pride
Tau  alzheimer’s disease  astrocyte 
ProteomicsTruncated Tau
Tau is a microtubule-associated protein that ensures neuronal shape and function. Besides, Tau is a central player in Alzheimer’s disease (AD) and related Tauopathies where it is found aggregated in degenerating neurons. Mechanisms leading to Tau pathology and its progression are far from being eluc...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-27 | MSV000081020 | MassIVE
ProteomicsAnalysis of pathological tau associated with a wide range of tauopathies
We have analyzed and compared the post-translational modifications in the pathological tau proteins prepared from a wide range of tauopathies.
ORGANISM(S): Homo Sapiens (human) 
2020-07-15 | PXD020371 | JPOST Repository
GenomicsTau aggregates are RNA-protein assemblies that mis-localize multiple nuclear speckle components
Tau aggregates are RNA-protein assemblies that mis-localize multiple nuclear speckle components
PRJNA625487 | ENA
ProteomicsSpecific post-translational modifications of the soluble tau protein distinguish between Alzheimer’s disease, 4R-, and 3R-tauopathies
The tau protein aggregates in several neurodegenerative disorders, referred to as tauopathies. The type of tau isoforms (4R/3R) observed in brain aggregates is used to classify tauopathies. However, distinguishing tauopathies in cerebrospinal fluid remains challenging. Here, we demonstrated that the...
ORGANISM(S): Homo sapiens (Human) 
2023-06-22 | PXD038901 | Pride
Brain Post-translational modifications Humain Tau Tauopathies 
ProteomicsPathogenic human tau in the Line 66 model of frontotemporal dementia
Transgenic human tau in subcellular fractions extracted after electrophoresis of L66 mouse brain extract. For higher sequence coverage trypsin (Tr) and thermolysin (TL) digests were analysed.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2020-08-13 | MSV000085945 | MassIVE
ProteomicsAggregation-state–resolved analysis of the tau interactome in Alzheimer’s disease
This project investigates how tau-associated protein networks are remodelled in Alzheimer’s disease and how these changes relate to the progression of tau aggregation in the human brain. Using post-mortem brain tissue from individuals with Alzheimer’s disease and age-matched healthy controls, the st...
ORGANISM(S): Homo sapiens (Human) 
2026-09-28 | PXD072117 | Pride
Human Brain Tau aggregates Interactome 
TranscriptomicsTau aggregates are RNA-protein assemblies that mis-localize multiple nuclear speckle components
We report the isolation and sequencing of tau aggregates from [1] HEK293 cells expressing Tau-RD-P301S-CFP/YFP that have been seeded with preformed fibrils from the brain of P301S mice (B6-Tg(Thy1-MAPT*P301S)2541; referred to as Tg2541 mice). Tau aggregates were isolated by differential centrifugati...
ORGANISM(S): Mus musculus Homo sapiens 
2021-04-06 | GSE148716 | GEO
ProteomicsBassoon contributes to tau-seed neurotoxicity and propagation.
Tau aggregates are critical pathological features of Alzheimer’s disease (AD) and other tauopathies. Growing evidence suggests that soluble tau aggregates trigger neurodegenerative phenotypes. However, the nature of the tau species and interactors involved in its aggregation and spreading remains un...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD027451 | Pride
Tauopathy Psp Bassoon. Brain Ad Tau Neurotoxicity Lc-msms Aggregation Propagation 
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