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GenomicsX-chromosome dynamics revealed by the RNA interactome and chromosomal binding of CTCF
CTCF is a master regulator that plays a role in genome architecture and gene expression. A key aspect of CTCF’s mechanism involves bringing together distant genetic elements for intra- and inter-chromosomal interactions. Evidence from epigenetic processes, such as X-chromosome inactivation (XCI), su...
ORGANISM(S): Mus musculus 
2015-01-09 | E-GEOD-58242 | biostudies-arrayexpress
TranscriptomicsA comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation
The inactive X chromosome (Xi) serves as a model to understand gene silencing on a global scale. Here, we perform identification of direct RNA interacting proteins? (iDRiP) to isolate a comprehensive protein interactome for Xist, an RNA required for Xi silencing. We discover multiple classes of inte...
ORGANISM(S): Mus musculus 
2015-06-19 | E-GEOD-67516 | biostudies-arrayexpress
ProteomicsReader interactome of epigenetic histone marks in birds
Lysine methylation is part of the posttranscriptional histone code employed to recruit modification specific readers to chromatin. Unbiased, quantitative mass spectrometry approaches combined with peptide pull-downs have been used to study histone methylation-dependent binders in mammalian cells. He...
ORGANISM(S): Gallus gallus (Chicken) Taeniopygia guttata (Zebra finch) (Poephila guttata) 
2016-01-04 | PXD002282 | Pride
Histone Birds Lc-msms Interactome 
ProteomicsDevelopment of nucleus-targeted synthetic histone photoaffinity probes
Dissection of the physiological interactomes of histone post-translational modifications (hPTMs) is crucial for understanding fundamental epigenetic regulatory pathways. Current peptide- or protein-based histone photoaffinity probes have greatly expanded the ability to probe the epigenetic interacto...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-21 | PXD045620 | Pride
Nucleus-targeted histone photoaffinity probe Lactylation The epigenetic interactome Hard-to-transfect cells Native cells 
GenomicsTargeting the CALR Interactome in Myeloproliferative Neoplasms
Targeting the CALR Interactome in Myeloproliferative Neoplasms
PRJNA491714 | ENA
UnknownDevelopment of nucleus-targeted histone-tail-based photoaffinity probes to profile the epigenetic interactome in native cells.
Not available
S-EPMC11704063 | biostudies-literature
ProteomicsThe Akirin2 regulome and interactome reveal gene/protein targets, candidate functional complements and role in epigenetic regulation
The Akirin (AKR) family of transcription cofactors are involved in the regulation of different biological processes such as immunity, interdigital regression, muscle and neural development throughout the metazoan. This model regulatory proteins do not have catalytic or DNA-binding capability and exe...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022073 | Pride
Regulome Akirin2 Knockdown Interactome Hl60 
GenomicsElucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma
Elucidation of the BMI1 interactome identifies novel regulatory roles in glioblastoma
PRJNA670408 | ENA
ProteomicsEpigenetic inactivation of the 5-methylcytosine RNA methyltransferase NSUN7 is associated with clinical outcome and therapeutic vulnerability in liver cancer
RNA modifications are important regulators of transcript activity and an increasingly emerging body of data suggest that the epitranscriptome and its associated enzymes are altered in human tumors. In this study, the initial screening for genetic and epigenetic defects of 5-methylcytosine RNA methyl...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD038422 | Pride
Maxquant Nsun7 Interactome Label free Methyltransferase 
UnknownIdentification of the RSX interactome in a marsupial shows functional coherence with the Xist interactome during X inactivation.
Not available
S-EPMC11112854 | biostudies-literature
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