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MetabolomicsUltra-High Mass Resolving Power, Mass Accuracy, and Dynamic Range MALDI Mass Spectrometry Imaging by 21-T FT-ICR MS

Detailed characterization of complex biological surfaces by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) requires instrumentation that is capable of high mass resolving power, mass accuracy and dynamic range. Fourier transform ion cyclotron resonance mass sp...

2022-01-28 | MTBLS3154 | MetaboLights
ProteomicsTMT proteomics of Cmtr1 cKO naive CD4 T cells
We aim to find the gene-specific effects of Cmtr1 KO in mouse CD4 T cells. TMT proteomics datasets were generated to find out which proteins are dependent on Cmtr1 for their expression.
ORGANISM(S): Mus musculus (Mouse) 
2025-10-16 | PXD058819 | Pride
T cell lymphocyte cmtr1 rna cap 
ProteomicsTMT proteomics of Cmtr1 cKO activated CD4 T cells
We aim to find the gene-specific effects of Cmtr1 KO in mouse CD4 T cells. TMT proteomics datasets were generated to find out which proteins are dependent on CMTR1 for their expression.
ORGANISM(S): Mus musculus (Mouse) 
2025-10-16 | PXD058851 | Pride
T cell lymphocyte cmtr1 cap rna 
ProteomicsDefining the T cell proteome and the role of mTORC1 during differentiation using quantitative proteomics
High-resolution quantitative mass-spectrometry reveals similarities and disparities in how murine naïve CD4 and CD8 T cells respond to immune activation and re-structure proteomes as they differentiate to effector cells. The data map core transcriptional, metabolic and protein synthesis machinery, n...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-28 | PXD012058 | Pride
Mouse T cell Mtorc1 Fusion Tmt Mtor Rapamycin 
ProteomicsThe NAE1-mediated Neddylation operates as an essential post-translational modification checkpoint for effector CD8+ T cells
Cells were lysed with TFA, and precipitated with cold acetone. The precipitates were transferred to E3filters and digestion was performed overnight with trypsin. The peptides were desalted with StageTips, and were analyzed on Eclipse Orbitrap with DIA mode. For MS1, the resolution was set to 120,00...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-02-27 | MSV000094179 | MassIVE
ProteomicsImmunological Proteome Resource (ImmPRes): Liver derived CD4+ T cell proteomes
T cells play a critical role in liver immunity and take part both in the initiation and in the resolution of intrahepatic inflammation. The liver contains conventional CD4 T cells, and Natural Killer T (NKT) cells that express an invariant Vα14 T cell receptor that recognizes glycolipid/CD1d antig...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-26 | PXD036319 | Pride
Cd4 Liver T cell Nkt Tmt 
ProteomicsLack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development
Regulatory T (Treg) cells are essential for the maintenance of immunological tolerance, yet the molecular components required for their maintenance and effector functions remain incompletely defined. Inactivation of VPS34 in Treg cells led to an early, lethal phenotype, with massive effector T cell ...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-29 | PXD048981 | Pride
Mouse Vps34 Pi3k T cells T regs 
TranscriptomicsMurine DN T-reg cells impart prolonged cardiac allograft survival
Recent studies have demonstrated that both mouse and human alpha beta TCR(+)CD3(+)NK1.1(-)CD4(-)CD8- double-negative regulatory T (DN Treg) cells can suppress Ag-specific immune responses mediated by CD8+ and CD4+ T cells. To identify molecules involved in DN Treg cell function, we generated a panel...
ORGANISM(S): Mus musculus 
2005-07-29 | E-GEOD-3024 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse double-negative regulatory T Cells
Lee et al. (2005)Expression Profiling of Murine Double-Negative Regulatory T Cells Suggest Mechanisms for Prolonged Cardiac Allograft Survival. The Journal of Immunology, 2005, 174: 4535 4544. Type 2 experiment where functional DN T-reg cells (CN4 or TN12) were cy-3 labeled and co-hybridized with n...
ORGANISM(S): Mus musculus 
2005-07-21 | E-SMDB-3283 | biostudies-arrayexpress
ProteomicsProteome of CD4 T cells activated through the TCR in the presence of IL2 and IL12 - Part 1
To activate primary T cells, lymph nodes were removed and disaggregated. Cells were cultured in RPMI 1640 containing L-glutamine, 10% FBS, 50 μM β-mercaptoethanol and penicillin/streptomycin. Cells were stimulated with 1 μg/ml of the CD3 monoclonal antibody (2C11) and 2 μg/ml anti-CD28 (37.51) in t...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-29 | PXD012052 | Pride
Metabolism Methioine Transport T cells 
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