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ProteomicsN‑Glycoproteomics Study of Putative N‑Glycoprotein Biomarkers of Drug Resistance in MCF‑7/ADR Cells
Currently, drug resistance of anti-cancer therapy has become the main cause of low survival rate and poor prognosis. Full understanding of drug resistance mechanisms is an urgent request for further development of anti-cancer therapy and improvement of prognosis. Here we present our N-glycoproteomi...
ORGANISM(S): Homo sapiens (Human) 
2023-12-30 | PXD036101 | Pride
Mcf-7/adr cells · mcf-7 cells · drug resistance · diferential n-glycosylation · n-glycoproteomics 
Proteomicsmonoclonal antibody NIST8671 LC-MS/MS
The characteristics of monoclonal antibodies (mAbs) cohering various function effectors shows great expectation in therapy. Glycosylation, one of the common post-translational modifications, deeply influences the cohesion. It is necessary to grasp monosaccharide composition/sequence and glycan struc...
ORGANISM(S): Homo sapiens (Human) 
2022-04-14 | PXD032275 | Pride
Monocloanl antibody nist8671 
ProteomicsLarge-scale identification and visualization of human Liver N-glycome enriched from LO2 cells
Large-scale identification and visualization of human Liver N-glycome enriched from LO2 cells
ORGANISM(S): Homo sapiens (Human) 
2018-05-09 | PXD008158 | Pride
Lo2 N-glycome Human Liver 
ProteomicsComparative glycomics study of N-glycans in breast cancer cell line MCF7 versus normal cell line
This study designed to characterize the differences in N-glycan expressions between normal and breastcancer cells, MCF10A and MCF7. Permethylated N-glycans released by PNGase F were enriched and then analyzed by LC-ESI/MS. The in-house-developed software GlySeeker was used to search IDs of N-glycan...
ORGANISM(S): Homo sapiens (Human) 
2022-03-02 | PXD010454 | Pride
Lc-esi/ms Breast cancer Mcf7 cell 
ProteomicsHuman Breast LC-MSMS - Quantitative site- and structure-specific N-glycoproteomics characterization of differential N-glycosylation in MCF-7/ADR cancer stem cells
Cancer stem cells (CSCs) are reported to be responsible for tumor initiation, progression, metastasis, and therapy resistance where P-glycoprotein (P-gp) as well as other glycoproteins are involved. Identification of these glycoprotein markers is critical for understanding the resistance mechanism a...
ORGANISM(S): Homo sapiens (Human) 
2020-02-21 | PXD013836 | Pride
Human Breast Lc-msms Cscs Mcf7/adr 
Proteomicsdifferentially expressed N-glycopeptides in HepG2 related to LO2 cell line
With isotopically dimethyl labeling, ZIC-HILIC enrichment, C18 pre-fractionation, differentially expressed N-glycosylation in HCC HepG2 cells (relative to normal liver LO2 cells) were analyzed using penta-HILIC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2019-05-31 | PXD012424 | Pride
N-glycopeptides Q excactive Human liver Hcc 
ProteomicsA comprehensive landscape of human organ N-glycoproteome
N-glycosylation, as a common post-translational modification with enormous structures, plays key roles in protein folding, cellular recognition and signaling pathways. State-of-the-art mass spectrometry-based N-glycoproteomics has enabled deep N-glycoproteome characterization of various human organs...
ORGANISM(S): Homo sapiens (Human) 
2026-05-13 | PXD070547 | Pride
Tissue Human N-glycosylation Profile 
ProteomicsOVA N-glycans PGC-LC-MSMS - Large-scale identification and visualization of N-glycans with primary structures using GlySeeker
With PNGase F digestion, PGC enrichment,OVA N-glycans were analyzed using PGC nanoLC-ESI-MS/MS.Datasets were analyzed by the N-glycan database search engine called GlycanGoggle developed in our group.
ORGANISM(S): Gallus gallus (Chicken) 
2019-01-17 | PXD006400 | Pride
Pgc-lc-msms Ova N-glycans 
ProteomicsHuman stomach LC-MSMS China Human Proteome Project
With the optional setting of multiple stepped collisional energies (NCEs), higher-energy collisional dissociation (HCD) as available on Orbitrap instruments is a widely adopted dissociation method for intact N-glycopeptide characterization, where peptide backbones and N-glycan moieties are selective...
ORGANISM(S): Homo sapiens (Human) 
2020-05-11 | PXD016865 | Pride
Human Lc-msms Hcd Stepped nces Stomach 
ProteomicsPutative N-glycoprotein markers of MCF-7/ADR cancer stem cells from N-glycoproteomics characterization of the whole cell lysate
Being the most malignant disease among females, breast cancer has morbidity and mortality in the first and second positions among various cancers [1]. Up to now, chemotherapy has been the most common therapy [2]; however, multidrug resistance (MDR) often occurs to give low overall survival rate. Thu...
ORGANISM(S): Homo sapiens (Human) 
2023-07-04 | PXD036095 | Pride
Mcf-7/adr cscsmcf-7 cscsdrug resistancedifferential n-glycosylationn-glycoproteomics 
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