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MetabolomicsCocaine administration and withdrawal (part II)
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ORGANISM(S): Rattus norvegicus 
ST000555 | MetabolomicsWorkbench
MetabolomicsIntegrated Analyses of the Gut Microbiota, Intestinal Permeability and Serum Metabolome Phenotype in Rats with Alcohol Withdrawal Syndrome
The etiology of alcohol dependence is not completely understood. Increasing evidence reveals that gut microbiota dysbiosis is associated with certain psychiatric disorders, including alcoholism, through the 'microbiota-gut-brain' axis. The aims were to evaluate the effect of alcohol abuse on the gut...
2021-07-30 | MTBLS2688 | MetaboLights
TranscriptomicsEffects of cocaine and withdrawal on the mouse nucleus accumbens transcriptome.
Genetic association studies, pharmacological investigations and analysis of mice-lacking individual genes have made it clear that Cocaine administration and Withdrawal have a profound impact on multiple neurotransmitter systems. The GABAergic medium spiny neurons of the nucleus accumbens (NAc) exhib...
ORGANISM(S): Mus musculus 
2013-01-10 | E-GEOD-43410 | biostudies-arrayexpress
TranscriptomicsEffect of Sunitinib treatment withdrawal on Immunodeficient mice bearing MDA-MB231 tumors
Immunodeficient RAG1-/- mice bearing MDA-MB231-LUC+ tumors of 50-70 mm3 were daily administrated by gavage with vehicle (containing, 0.5% carboxymethylcellulose, 1.8 % NaCl, 0.4 % Tween-80, 0.9 %. benzyl alcohol, and ultrapure water adjusted to pH 6.0) or sunitinib (40mg/kg/day) for 30 days followed...
ORGANISM(S): Mus musculus 
2014-08-24 | E-GEOD-50795 | biostudies-arrayexpress
TranscriptomicsTranscriptional effects of chronic heroin and methamphetamine treatment in the mouse striatum
To identify molecular effects of chronic drug treatment, heroin and methamphetamine treated animals were compared with saline treated animals at multiple time-points using microarray technology. Gene expression profile was assessed 14 h after the last dose of 1, 3, 6 or 12 days drug treatment and af...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-30305 | biostudies-arrayexpress
TranscriptomicsPrefrontal cortex gene expression in WSP and WSR male and female mice following chronic ethanol exposure during peak withdrawal at 8hr
While women are more vulnerable than men to many of the medical consequences of alcohol abuse, the role of sex in the response to ethanol is controversial. Neuroadaptive responses that result in the hyperexcitability associated with withdrawal from chronic ethanol likely reflect gene expression chan...
ORGANISM(S): Mus musculus 
2014-09-17 | E-GEOD-56249 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of endothelial cell apoptosis induced by serum withdrawal
To understand the regulatory relationships among EC transcripts during apoptosis using serum withdrawal time series microarray data and use this to identify master regulators of endothelial cell apoptosis. In the study presenty here, HUVEC isolates from 10 different individuals were pooled. The extr...
ORGANISM(S): Homo sapiens 
2012-07-19 | E-GEOD-23067 | biostudies-arrayexpress
ProteomicsProteomic analysis reveals the neurotoxic effects of chronic methamphetamine self-administration-induced cognitive impairments and the role of melatonin-enhanced restorative process during drug withdrawal.
, this study aimed to investigate the mechanisms underlying neuropathological processes related to cognitive impairment in mice chronically-treated with METH. In addition, the effective melatonin on recovery of neurological dysfunction and neurobehavioral deficits during METH withdrawal was also inv...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD043828 | Pride
Mitophagy Cognitive function Methamphetamine Neurotoxicity Mitochondria Neuroplasticity Drug addiction Neurodegeneration Proteomics. Melatonin 
TranscriptomicsImportance of genetic background for risk of relapse shown in altered prefrontal cortex gene expression during abstinence following chronic alcohol intoxication.
Alcoholism is a relapsing disorder associated with excessive consumption after periods of abstinence. Neuroadaptations in brain structure, plasticity and gene expression occur with chronic intoxication but are poorly characterized. Here we report identification of pathways altered during abstinence ...
ORGANISM(S): Mus musculus 
2011-01-05 | E-GEOD-23165 | biostudies-arrayexpress
TranscriptomicsPrefrontal cortex gene expression in WSP and WSR male and female mice following 72h of chronic ethanol vapor exposure
Ethanol is the most common substance of abuse in the US, and abuse can lead to physical dependence, addiction, brain damage and premature death. The cycle of alcohol addiction has been described as a composite consisting of three stages: intoxication, withdrawal and craving/abstinence. As a comple...
ORGANISM(S): Mus musculus 
2014-09-17 | E-GEOD-56247 | biostudies-arrayexpress
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