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ProteomicsArsenic induces reversible nitrosative stress and behavioural changes in mice
Studies on exposure of mice to Arsenic, combined with unique tools developed in our laboratory to determine the consequences of NO formation in mouse brain and neuronal cell culture, will probe mechanistic pathways of nitrosative damage operable in behavioural development.
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD012691 | Pride
Nitric oxide Brain Autism. s-nitrosylation Snotrap Arsenic 
ProteomicsS-nitrosylation in P301S mouse tauopathy model
We looked to find earlier molecular changes in 2-month-old transgenic P301S mice. S-nitrosylated (SNO) proteins were identified in two brain regions, cortex and hippocampus, in P301S and Wild Type (WT) littermate control mice.
ORGANISM(S): Mus musculus (Mouse) 
2019-11-08 | PXD010106 | Pride
Tauopathy Nitric oxide Mass spectrometry S-nitrosylation Tau Alzheimer's 
ProteomicsS-nitrosation of proteins relevant to Alzheimer’s disease during early stages of neurodegeneration
Protein S-nitrosation (SNO-protein) is a post-translational modification in which a cysteine (Cys) residue is modified by nitric oxide (SNO-Cys). SNO-proteins impact many biological systems, but their identification has been technically challenging. We developed a chemical proteomic strategy - SNOTR...
ORGANISM(S): Mus musculus (Mouse) 
2016-03-31 | PXD003802 | Pride
S-nitrosylation Alzheimer's disease Neurodegeneration 
TranscriptomicsmicroRNA and mRNA expression profiles of human embryonic stem cells treated with activin A
Human embryonic stem (hES) cells have the capacities to propagate for extended periods and to differentiate into cell types from all three germ layers both in vitro and in vivo. These characteristics of self-renewal and pluripotency enable hES cells having the potential to provide an unlimited suppl...
ORGANISM(S): Homo sapiens 
2010-09-10 | E-GEOD-16910 | biostudies-arrayexpress
ProteomicsCompositional analysis of extracellular aggregates in the eyes of patients with exfoliation syndrome and exfoliation glaucoma.
Exfoliation syndrome (XFS) is a condition characterized by the production of insoluble fibrillar aggregates (exfoliation material; XFM) in the eye and elsewhere. Many patients with XFS progress to exfoliation glaucoma (XFG), a significant cause of global blindness. We used quantitative mass spectrom...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026764 | Pride
Human Exfoliation syndrome Shotgun proteomics Psr-ohsu Lens capsule Aqueous humor Tmt labeling Quantitative proteomics Exfoliation glaucoma 
UnknownA feeder-free culture using autogeneic conditioned medium for undifferentiated growth of human embryonic stem cells: comparative expression profiles of mRNAs, microRNAs and proteins among different feeders and conditioned media.
Not available
S-EPMC2958897 | biostudies-literature
ProteomicsFight-or-flight responses require augmentation of Ca2+ influx via Rad phosphorylation
Fight-or-flight responses involve β-adrenergic-induced increases in heart rate and contractile force. Despite decades of investigations, predominantly focusing on ryanodine receptor and phospholamban phosphorylation, the molecular mechanisms underlying the sympathetic nervous system control of cardi...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-26 | PXD033492 | Pride
Contractility Heart Mass spectrometry Adrenergic Calcium Phosphorylation Pka Phosphatases Ion channels 
TranscriptomicsmicroRNA and mRNA expression profiles of human pancreatic islet-like cell clusters
Type 1 diabetes is an autoimmune destruction of pancreatic islet beta cell disease, and it is important to find new alternative source of the islet beta cells to replace the damaged cells. Human embryonic stem (hES) cells possess unlimited self-renewal and pluripotency and thus have the potential to...
ORGANISM(S): Homo sapiens 
2010-09-29 | E-GEOD-14503 | biostudies-arrayexpress
ProteomicsFacile one-pot nanoproteomics for label-free proteome profiling of 50-1000 mammalian cells
We report a facile one-pot nanoproteomics method termed SOPs-MS (Surfactant-assisted One-Pot sample processing at the standard volume coupled with MS) for convenient proteome profiling of 50-1000 mammalian cells. Building upon our recent development of SOP-MS for label-free single-cell proteomics at...
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse) 
2022-05-11 | PXD025918 | JPOST Repository
ProteomicsFacile one-pot nanoproteomics for label-free proteome profiling of 50-1000 mammalian cells
We report a facile one-pot nanoproteomics method termed SOPs-MS (Surfactant-assisted One-Pot sample processing at the standard volume coupled with MS) for convenient proteome profiling of 50-1000 mammalian cells. Building upon our recent development of SOP-MS for label-free single-cell proteomics at...
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse) 
2021-07-23 | PXD026009 | JPOST Repository
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