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ProteomicsProteomic maps of breast cancer subtypes
Systems-wide profiling of breast cancer has so far built on RNA and DNA analysis by microarray and sequencing techniques. Dramatic developments in proteomic technologies now enable very deep profiling of clinical samples, with high identification and quantification accuracy. We analyzed 40 estrogen ...
ORGANISM(S): Homo sapiens (Human) 
2016-01-05 | PXD002619 | Pride
Classification Shotgun proteomics Breast cancer subtypes 
OtherMachine Learning Based Classification of Diffuse Large B-cell Lymphoma Patients by their Protein Expression Profiles.
Data from ProteomeXchange, PXD ID: PXD002052. Experiment: TRR37, file: folder summary. Published as part of Mol Cell Proteomics. 2015 Aug 26 . From the Abstract: {{i}} ... Here, we develop a state of the art quantitative mass spectrometric pipeline to characterize formalin-fixed paraffin-embedded (...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320017943 | GPMDB
Resource Reanalysis 
ProteomicsMachine Learning Based Classification of Diffuse Large B-cell Lymphoma Patients by their Protein Expression Profiles
Characterization of tumors at the molecular level has improved our knowledge of cancer causation and progression. Proteomic analysis of their signaling pathways promises to enhance our understanding of cancer aberrations at the functional level, but this requires accurate and robust tools. Here, we ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-30 | MSV000080813 | MassIVE
ProteomicsLung cancer patients display increased expression of Bovine Meat and Milk Factor (BMMF) proteins in peritumor alveolar macrophages
Besides smoking and exposure to specific environmental risk factors, also diet and in particular red meat consumption/exposure are described as risk factors contributing to lung cancer development. Incidence of non-smoking associated lung cancer is rising rapidly, globally. Global epidemiology supp...
ORGANISM(S): Homo sapiens (Human) 
2026-06-03 | PXD077096 | Pride
Lung cancer  bovine meat and milk factors  chronic inflammation  dietary cancer risk factors  indirect carcinogenesis 
ProteomicsHigh-throughput screening and proteomic characterization of compounds targeting myeloid-derived suppressor cells
Myeloid-derived suppressor cells are a heterogeneous cell population of incompletely differentiated immune cells. They are known for suppressing T cell activity and are implicated in multiple chronical diseases, which makes them an attractive drug target for the pharmaceutical industry. Here, we dif...
ORGANISM(S): Homo sapiens (Human) 
2023-08-15 | PXD043407 | Pride
Mdsc Proteomics Screening Ptm Phosphorylation 
ProteomicsUnconventional RNA-binding proteins in mitosis
Ribonucleoprotein complexes are dynamic assemblies of RNA associated with RNA-binding proteins (RBPs), which can modulate the fate of the RNA molecules from transcription to degradation. Dysregulation of RBPs is linked to diseases such as cancer and neurological disorders, which motivated the develo...
ORGANISM(S): Homo sapiens (Human) 
2025-02-25 | PXD056233 | Pride
Rna-dependent protein-protein interactions Mitotic factors Rna-binding proteins 
ProteomicsSelective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordoma
Aberrant expression of the embryonal transcription factor TBXT (also known as brachyury) drives chordoma, a rare spinal neoplasm with no effective drug therapies. The gene network regulated by TBXT is poorly understood, and strategies to disrupt its abnormal activity for therapeutic purposes are lac...
ORGANISM(S): Homo sapiens (Human) 
2025-07-31 | PXD055982 | Pride
Tbxt Chordoma Darpin Brachyury 
ProteomicsProteomic maps of breast cancer subtypes
Systems-wide profiling of breast cancer has so far built on RNA and DNA analysis by microarray and sequencing techniques. Dramatic developments in proteomic technologies now enable very deep profiling of clinical samples, with high identification and quantification accuracy. We analyzed 40 estrogen ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080757 | MassIVE
ProteomicsThe function of the Receptor for Advanced Glycation End Products (RAGE) in ductular reaction-mediated liver fibrosis during cholestasis
Ductular reaction (DR) is the hallmark of cholestatic diseases manifested in the proliferation of bile ductules lined by biliary epithelial cells (BECs). It is commonly associated with increased risk of fibrosis and liver failure. The Receptor for Advanced Glycation End Products (RAGE) was identifie...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-16 | PXD065854 | Pride
Biliary epithelial cells chronic liver injury genetically modified mice hepatic stellate cells receptor for advanced glycation end products 
ProteomicsA Mitochondria-Driven Quality Control Pathway Eliminates Mislocalized Peroxisomal Membrane Proteins
Protein quality control (PQC) systems are essential for maintaining a healthy proteome by removing aberrant proteins, including mislocalized proteins. However, the mechanisms for eliminating mislocalized Peroxisomal Membrane Proteins (PMPs) have remained elusive. Here, using quantitative proteomics ...
ORGANISM(S): Homo sapiens (Human) 
2026-05-14 | PXD069489 | Pride
Peroxisome Protein degradation March5 E3 ligases Mul1 Ubiquitin Protein quality control Peroxisomal membrane proteins (pmps) 
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