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ProteomicsNew insight into sclerotial generation in medicinal fungus Polyporus umbellatus
Polyporus umbellatus sclerotia are medicinal tissue, but little is known about acetylome of sclerotia generated from hyphae. Based on acetylome analysis results and expression levels of targeted protein that associated with sclerotia generation were verified by PRM using Orbitrap Fusion (Thermo-Fish...
ORGANISM(S): Polyporus umbellatus GSX09 
2022-05-20 | PXD031198 | Pride
Polyporus umbellatus Ultimate3000 rslc nano 
ProteomicsProteomic analysis of collagen membrane and matrix
High-resolution shotgun proteomic analysis on two porcine collagen-based biomaterials designed for guided bone regeneration and soft tissue augmentation was perfomed. A porcine-derived collagen membrane and a collagen matrix derived from peritoneum and/or skin were digested, separated by nano-revers...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-09-09 | PXD019298 | Pride
Soft tissue augmentation Collagen Bone regeneration 
ProteomicsSerum proteomic pattern in female stress urinary incontinence
The pathophysiology of Stress Urinary Incontinence (SUI) is poorly understood. The aim of this study was to identify the serum proteomic profile in patients with SUI and to replicate findings from a preceding study in which a significant difference in the urinary proteome was identified. Serum samp...
ORGANISM(S): Homo sapiens (Human) 
2018-01-24 | PXD008553 | Pride
Urinary incotinence Proteomics Female Serum Stress 
ProteomicsExtensive Rewiring of the EGFR Network in Colorectal Cancer Cells Expressing Transforming Levels of KRASG13D
RAW files of full proteome profiling of SILAC labeled HCT 116 and HKE 3 cells
ORGANISM(S): Homo sapiens (Human) 
2019-12-03 | PXD016549 | Pride
Egfr pathway Ap-ms Interactomic Silac Proteins network Hke-3 Hct-116 Proteomic profiling 
ProteomicsParalogue specific TTC30A knockout downregulates Sonic hedgehog signaling
Cilia assembly, maintenance and the localization of signal-transduction proteins necessitate a functioning intraflagellar transport (IFT). The IFT machinery moves cargo along a microtubule scaffold from the proximal to the distal end of the cilium. This anterograde transport is facilitated by a larg...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD044183 | Pride
Ttc30 paralogues Sonic hedgehog signaling Affinity proteomics Ift Pka Cilia 
ProteomicsIdentification of RNA binding proteins that interact with AU-rich elements of Lif 3`UTR
Leukemia inhibitory factor (LIF) is an important endogenous factor for photoreceptor protection. Lif is known to be upregulated both in induced and inherited disease models of photoreceptor degeneration only in a subset of Muller cells. Since Lif is induced in Muller cells in response to photorecept...
ORGANISM(S): Rattus norvegicus (Rat) 
2016-07-20 | PXD001463 | Pride
Ltq orbitrap velos Silac Rna-pulldown Maxquant 
ProteomicsProteomic analysis of leaf development in wild-type tobacco plants and siblings expressing a chloroplast-targeted cyanobacterial flavodoxin
Foliar development involves successive phases of cell proliferation and expansion that determine the final leaf size, and is characterized by an early burst of reactive oxygen species generated in the photosynthetic electron transport chain (PETC). To further characterize this process, we performed ...
ORGANISM(S): Nicotiana tabacum (Common tobacco) 
2024-03-13 | PXD041855 | Pride
Tobacco Leaf development Label-free quantitative proteomics Flavodoxin 
ProteomicsCFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module
Axonemal dynein ATPases direct eukaryotic ciliary and flagellar beating via adenosine triphosphate (ATP) hydrolysis. The modulatory effect of adenosine monophosphate (AMP) and adenosine diphosphate (ADP) on flagellar beating is not fully understood. Here we describe a deficiency of CFAP45 in both hu...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2020-11-05 | PXD019806 | Pride
Motile cilia Protein complexes Cfap45 
ProteomicsNAD+/NADH Redox Alterations Reconfigure Metabolism and Rejuvenate Senescent Human Mesenchymal Stem Cells In Vitro
Human mesenchymal stem cells (hMSCs) promote endogenous tissue regeneration and have become a promising candidate for cell therapy. However, in vitro culture expansion of hMSCs induces a rapid decline of stem cell properties through replicative senescence. Here we characterize metabolic profiles of...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022395 | Pride
Msc 
ProteomicsAccurate Prediction of Kinase-Substrate Networks Using Knowledge Graphs
Phosphorylation of specific substrates by protein kinases is a key control mechanism for vital cell-fate decisions and other cellular processes. However, discovering specific kinase-substrate relationships is time-consuming and often rather serendipitous. Computational predictions alleviate these ch...
ORGANISM(S): Homo sapiens (Human) 
2022-02-20 | PXD018905 | Pride
Statistical relational learning Cell signaling Kinase-substrate predictions Machine learning Linkphinder 
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