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TranscriptomicsIdentification of intermediate-sized non-coding RNAs involved in the UV-induced DNA damage response in C. elegans
We utilized high-throughput RNA-seq to uncover the intermediate-sized noncoding RNAs invovled in UV-DNA Damage Responses in C. elegans. 450 novel transfrags were discovered, some of which show dramatic expression change between the UV irradiation and control. This study should lead to a better under...
ORGANISM(S): Caenorhabditis elegans 
2012-05-01 | E-GEOD-37063 | biostudies-arrayexpress
ProteomicsProteomic discovery of DEK and NUMA1 as new players in UV-induced DNA damage repair mechanisms
Ultraviolet (UV)-induced DNA lesions threaten genomic stability and are associated with skin carcinogenesis. These lesions are primarily repaired by the nucleotide excision repair (NER) pathway. However, alternative repair mechanisms and regulators are emerging as critical contributors to managing U...
ORGANISM(S): Homo sapiens (Human) 
2025-12-01 | PXD061212 | Pride
Uv Uv Dek Numa1 Dna damage 
TranscriptomicsTranscription profiling of human skin fibroblasts to low and high doses of UVC radiation to assess cellular transcriptional responses to UVC-induced DNA damage
DNA damage caused by UV radiation initiates cellular recovery mechanisms, which involve activation of DNA damage response pathways, cell cycle arrest and apoptosis. To assess cellular transcriptional responses to UVC-induced DNA damage we compared time course responses of human skin fibroblasts to l...
ORGANISM(S): Homo sapiens 
2007-09-21 | E-GEOD-713 | biostudies-arrayexpress
GenomicsExcision repair hotspots of UV-induced DNA damage in the human genome
Excision repair hotspots of UV-induced DNA damage in the human genome
PRJNA623860 | ENA
ProteomicsPosttranslational modifications regulate cellular responses upon UV-induced DNA damage
SUMOylation is a posttranslational protein modification which is characterized by the covalent attachment of a small 11kDa protein, called Small Ubiquitin-like MOdifier (SUMO). SUMOylation plays a pivotal role in a multitude of cellular pathways including cellular responses upon DNA damage. Here, w...
ORGANISM(S): Homo sapiens (Human) 
2019-10-11 | PXD010609 | Pride
Human Post-translational modification Sumoylation Dna damage Csb Csa 
Proteomicsp38-MK2 signaling axis regulates RNA metabolism after UV light-induced DNA damage
Ultraviolet (UV) light radiation induces the formation of bulky photoproducts in the DNA that interfere with replication and transcription. Recent studies showed that exposure of human cells to UV light globally affects transcription and alternative splicing, however, the signaling pathways and mech...
ORGANISM(S): Homo sapiens (Human) 
2018-02-09 | PXD004255 | Pride
Uv Nelfe P38 Mk2 Phosphoproteomics 
TranscriptomicsCPD-seq mapping of UV damage formation and repair in yeast
UV-induced DNA lesions are an important contributor to mutagenesis and cancer, but it is not fully understood how the chromosomal landscape influences UV lesion formation and repair. We have used a novel high-throughput sequencing method to precisely map UV-induced cyclobutane pyrimidine dimers (CPD...
ORGANISM(S): Saccharomyces cerevisiae 
2016-08-19 | E-GEOD-79977 | biostudies-arrayexpress
ProteomicsRNF8 mediates NONO degradation following UV-induced DNA damage to properly terminate ATR-CHK1 checkpoint signaling
RNF8 is a key E3 ubiquitin ligase functioning in both DSB- and UV-induced DDR, identification of additional substrates will help further elucidate its role in DNA damage signaling. To identify substrates of ubiquitin ligases, we have recently devised a method based on proximity-dependent biotin labe...
ORGANISM(S): Homo sapiens (Human) 
2018-11-07 | PXD006156 | Pride
Substrate identification Rnf8 Dna damage E3 ligase 
ProteomicsH3K4me2 regulates the recovery of protein biosynthesis and homeostasis from UV-induced DNA damage during development and aging
DNA damage causes cancer, impairs development and accelerates aging. UV irradiation induces transcription-blocking lesions and defects in transcription-coupled nucleotide excision repair lead to developmental failure and premature aging in humans. Following DNA repair, the homeostatic processes need...
ORGANISM(S): Caenorhabditis elegans 
2020-10-13 | PXD015354 | Pride
Uv H3k4me2 C. elegans Dna damage 
GenomicsTRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism
DNA lesions encountered by replicative polymerases threaten genome stability and cell cycle progression. Here we report the identification of mutations in TRAIP, encoding an E3 RING ubiquitin ligase, in patients with microcephalic primordial dwarfism/Seckel syndrome. We establish that TRAIP relocali...
EGAS00001001501 | EGA
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