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ProteomicsPlatelet carbamylated protein LC-MS/MS
Urea undergoes natural hydrolysis to form cyanate, a reactive species capable of inducing protein carbamylation. To determine whether elevated urea levels promote carbamylation of platelet proteins, whether this modification is mediated by the urea transporter B (UT-B) expressed on platelets, and wh...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-28 | PXD066058 | Pride
Carbamylation Platelet Urea transporter b 
ProteomicsHuman platelet carbamylated protein LC-MS/MS
The concentration of blood urea is markedly elevated in patients with advanced chronic kidney disease (CKD). Urea undergoes natural hydrolysis to form cyanate, a reactive species capable of inducing protein carbamylation. To determine whether elevated urea levels promote carbamylation of platelet pr...
ORGANISM(S): Homo sapiens (Human) 
2026-05-28 | PXD067646 | Pride
Human Carbamylation Platelet Lc-ms/ms 
Proteomics15 cm Aurora Gen3 column benchmarking on an Exploris 480
A comprehensive proteome map is essential to elucidate molecular pathways and protein functions. Although great improvements in sample preparation, instrumentation and data analysis already yield-ed impressive results, current studies suffer from a limited proteomic depth and dynamic range there-for...
ORGANISM(S): Homo sapiens (Human) 
2024-02-13 | PXD045457 | Pride
Vanquish neo Orbitrap exploris 480 Trap-and-elute 
ProteomicsProteomics data of hepatocytes in metabolism dysfunction associated steatohepatitis.
In this study, metabolism dysfunction associated steatohepatitis (MASH) hepatocytes and normal hepatocytes were collected from three MASH mouse models and normal diet control fixed-frozen liver sections with laser capture microdissection (LCM), respectively. Protein was processed from these LCM sam...
ORGANISM(S): Mus Musculus 
PXD067929 |
ProteomicsIntegrated proteomic analysis of CD4⁺ T cells from DSS-induced colitis mice treated with Akkermansia muciniphila
This study investigates the effects of Akkermansia muciniphila on CD4⁺ T cells in a DSS-induced colitis mouse model. Spleen-derived CD4⁺ T cells were isolated from mice treated with either A. muciniphila or PBS by oral gavage, followed by DSS administration. Proteomic profiling was performed using L...
ORGANISM(S): Mus Musculus 
PXD069245 |
ProteomicsQuantitative TMT proteomics of myristoylated proteins in Trypanosoma cruzi and human cardiomyocytes during N-myristoyltransferase inhibition
This project investigates the impact of N-myristoyltransferase (NMT) inhibition on the myristoylated proteome of Trypanosoma cruzi and human cardiomyocytes in the context of Chagas disease. Human AC16 cardiomyocytes were infected with T. cruzi (CL Brener strain) and treated with the reference NMT in...
ORGANISM(S): Trypanosoma cruzi Homo sapiens (Human) 
2026-01-26 | PXD071927 | Pride
N-myristoyltransferase N-myristoylation Tmt sixplex Orbitrap exploris 240 Chagas disease Ac16 cardiomyocytes Trypanosoma cruzi Click chemistry Quantitative proteomics Lc–ms/ms 
ProteomicsBreak-induced replication is enhanced by a phospho-activated RPA-binding module in Pol32
Break-induced replication (BIR) mediates single-ended DNA double-strand break (DSB) repair. Upon strand invasion into a homologous repair template, BIR is catalysed by a minimal replisome comprising PCNA, DNA polymerase delta, and the Pif1 helicase. Here, we identify an interaction between Polymeras...
ORGANISM(S): Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2026-06-15 | PXD074712 | Pride
Cdc5 Break-induced replication Vanquish neo uhplc Ddk Orbitrap exploris 480 Pol32 Cka2 Saccharomyces cerevisiae 
ProteomicsBenchmarking of 5.5 cm, 50 cm and 110 cm micropillar array columns as compared to packed bed columns
A comprehensive proteome map is essential to elucidate molecular pathways and protein functions. Although great improvements in sample preparation, instrumentation and data analysis already yield-ed impressive results, current studies suffer from a limited proteomic depth and dynamic range there-for...
ORGANISM(S): Homo sapiens (Human) Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2024-02-13 | PXD039576 | Pride
E. coli Yeast Direct injection Micropillar array chromatography Vanquish neo Hela Orbitrap exploris 480 Trap-and-elute 
UnknownThermal inkjet makes label-free single-cell proteomics accessible and easy.
Not available
S-EPMC11371764 | biostudies-literature
MetabolomicsExercise-Associated Microbial Metabolites Prevent Skeletal Muscle Atrophy in Adult Mice
We previously reported that skeletal muscle adaptation to regular exercise requires a healthy gut microbiome, contributing to growing evidence that some exercise benefits are mediated by microbiome-derived metabolites. Here, to identify such exercise-associated microbial metabolites, we transfer cec...
2026-05-27 | MTBLS14386 | MetaboLights
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