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ProteomicsAPX2, the ascorbate peroxidase-related protein, regulates the levels of plastocyanin in Chlamydomonas
The function of ascorbate peroxidase-related (APX-R) proteins, present in all green photosynthetic eukaryotes, remains unclear. This study focuses on APX-R from Chlamydomonas reinhardtii, namely ascorbate peroxidase 2 (APX2). We showed that apx2 mutants exhibited a faster oxidation of the PSI primar...
ORGANISM(S): Chlamydomonas reinhardtii 
2024-01-29 | PXD046605 | Pride
Chlamydomonas Apx2 Plastocyanin Cytochrome c6 Copper-deficiency P700 
ProteomicsHuman Ovarian Proteome - A draft map of the human ovarian proteome for tissue engineering and clinical applications
Fertility preservation research in women today is increasingly taking advantage of bioengineering techniques to develop new biomimetic materials and solutions to safeguard ovarian cell function and microenvironment in vitro and in vivo. However, available data on the human ovary are limited and fund...
ORGANISM(S): Homo sapiens (Human) 
2018-02-27 | PXD008183 | Pride
Matrisome Ovarian Proteome 
ProteomicsDivide-and-conquer matrisome protein (DC-MaP) strategy: an optimal approach to proteomic matrisome characterization
Currently, the extracellular matrix (ECM) is considered a pivotal complex meshwork of macromolecules playing a plethora of biomolecular functions in health and disease beyond its commonly known mechanical role. Only by unravelling its composition, we can leverage related tissue engineering and pharm...
ORGANISM(S): Homo sapiens (Human) 
2020-12-03 | PXD020823 | Pride
Proteins Identifcation Matrisome Fractionation Human Ovarian 
ProteomicsTracking the dynamics of the glycolytic metabolite fructose 1,6-bisphosphate in liver cancer cells with a fluorescent biosensor
HYlight is a genetically encoded fluorescent biosensor that ratiometrically monitors fructose 1,6-bisphosphate (FBP), a key glycolytic metabolite. Given the role of glucose in liver cancer metabolism, we expressed HYlight in human liver cancer cells and primary mouse hepatocytes. Through in vitro, i...
ORGANISM(S): Homo sapiens (Human) 
2024-11-14 | PXD051879 | Pride
6-bisphosphate  hepatocellular carcinoma  metabolomics  biosensor Glycolysis  fructose 1 
ProteomicsIdentification of RSK substrates using an analog-sensitive kinase approach
RSK1 and RSK4 are two of the four members of the p90 ribosomal protein S6 kinases (RSK) family. These kinases are downstream kinases of mitogen-activated protein kinase 1 (ERK or MAPK1) in the ERK MAP kinase pathway. RSKs are implicated in fine tuning of cellular processes such as translation, trans...
ORGANISM(S): Homo sapiens (Human) 
2024-02-06 | PXD047020 | Pride
Rsk1 Rsk4 Mapk pathway Kinase Substrate 
ProteomicsIn vivo trapping of thioredoxin substrates
Thioredoxin (Trx) is a ubiquitous oxidoreductase maintaining protein-bound cysteine residues in the reduced thiol state. Here, we combined a well-established method to trap Trx substrates with the power of bacterial genetics to comprehensively characterize the in vivo Trx redox interactome in the mo...
ORGANISM(S): Escherichia coli 
2016-04-19 | PXD003098 | Pride
Trx1 Substrates E. coli 
ProteomicsProtein expression and phosphoproteome of brown adipose tissue in the hibernating ground squirrel
Mammalian hibernation is characterized by metabolic rate depression and a strong decrease in core body temperature that together create energy savings such that most species do not have to eat over the winter months. Brown adipose tissue (BAT), a thermogenic tissue that uses uncoupled mitochondrial ...
ORGANISM(S): Spermophilus tridecemlineatus (Thirteen-lined ground squirrel) 
2017-07-11 | PXD004261 | Pride
Mitochondrial protein expression Lipolysis Protein phosphorylation Metabolic depression 
ProteomicsComparative proteomic from different cocoa genotypes to reveals new insights into the common and fine-flavor metabolism
The organoleptic quality of cocoa beans relies on a combination of factors that include post-harvest processing and the genotype. Fine-flavor genotypes are characterized by their great organoleptic quality. Among these, the difference between the content of the storage proteins and endogenous enzyme...
ORGANISM(S): Theobroma cacao (Cacao) (Cocoa) 
2025-10-10 | PXD045216 | Pride
Cocoa flavor Unfermented cocoa beans Proteome Theobroma cacao 
ProteomicsUnique shaping of the chloroplastic iron-sulfur transfer protein NFU1 sustains dark chlorophyll synthesis and fermentation in Chlamydomonas reinhardtii
The sulfur mobilization (SUF) machinery is required for the synthesis of iron-sulfur (Fe- S) clusters and their insertion into client proteins in plastids. The final step relies on several Fe-S cluster transfer proteins, including NIFU-like (NFU) proteins. In this study, we focused on the chloroplas...
ORGANISM(S): Chlamydomonas reinhardtii 
2026-07-07 | PXD070162 | Pride
Iron-sulfur cluster  transfer protein Endonuclease domain  gyi-yig motif  nfu domains  green microalga  chloroplast 
ProteomicsIdentification, synthesis, and in vitro activity of antimicrobial peptide from African catfish against the Extended-Spectrum Beta-Lactamase (ESBL) producing Escherichia coli.
The global surge in multi-drug resistant bacteria, including extended-spectrum β-lactamase (ESBL)-producing Escherichia coli has led to a growing need for new antibacterial compounds. Despite being promising, the potential of fish-derived antimicrobial peptides (AMPs) in combating ESBL-E. coli is la...
ORGANISM(S): Clarias gariepinus 
2024-06-25 | PXD049239 | Pride
Catfish Esbls Antimicrobial peptides Drug discovery Lc-ms/ms 
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