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ProteomicsHepatocyte Deletion of Triglyceride-Synthesis Enzyme DGAT2 Reduces Steatosis without Increasing Inflammation or Fibrosis
Non-alcoholic fatty liver disease (NAFLD) is characterized by excess lipid accumulation in hepatocytes and reprepresents a huge public health problem owing to its propensity to progress to non-alcoholic steatohepatitis (NASH), fibrosis, and liver failure. The lipids stored in hepatic steatosis are p...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD013423 | Pride
Triacylglycerol Liver Diacylglycerol Nonalcoholic fatty liver disease Steatohepatitis Dietary lipids 
ProteomicsInhibiting sphingolipid synthesis improves outcomes and survival in GARP-mutant wobbler mouse, an ALS model
Defects of the endosomal and lysosomal systems have been increasingly linked to adult neurodegenerative diseases1,2. Deficiencies in the retrograde trafficking pathway between endosomes and the Golgi apparatus lead to forms of Alzheimer’s and Parkinson’s diseases in the case of retromer mutations, o...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD007981 | Pride
Lc-msms Silac Mef 
UnknownEffect of Carbohydration on the Theranostic Tracer PSMA I&T.
Not available
S-EPMC6068695 | biostudies-literature
UnknownTRPM7 and magnesium orchestrate human CD4 T-cell activation and differentiation.
Not available
S-EPMC12670122 | biostudies-literature
UnknownTRPM7 activity drives human CD4 T-cell activation and differentiation in a magnesium dependent manner.
Not available
S-EPMC11643021 | biostudies-literature
UnknownAberrant regulation of hematopoiesis by T cells in BAZF-deficient mice.
Not available
S-EPMC1952080 | biostudies-literature
UnknownTRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut.
Not available
S-EPMC5714948 | biostudies-literature
MetabolomicsGlobal Analyses of Selective Insulin Resistance in Hepatocytes due to Palmitate Lipotoxicity
Obesity is tightly linked to hepatic steatosis and insulin resistance. One feature of this association is the paradox of selective insulin resistance: insulin fails to suppress hepatic gluconeogenesis but activates lipid synthesis in the liver. How lipid accumulation interferes selectively with some...
2018-04-26 | MTBLS582 | MetaboLights
UnknownA P2rx7 Passenger Mutation Affects the Vitality and Function of T cells in Congenic Mice.
Not available
S-EPMC7733020 | biostudies-literature
ProteomicsFitm2 is required for ER homeostasis and normal function of murine liver
The ER-resident prote in fat-inducing transcript 2 (FIT2) catalyzes acyl-CoA cleavage in vitro, and in cells is required for endoplasmic reticulum (ER)homeostasis and normal lipid storage. The gene encoding FIT2 is essential for viability of mice and worms. Whether FIT2 acts as anacyl-CoA diphosphat...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD033884 | Pride
Lipid metabolism Acyl-coa Endoplasmic reticulum Liver Fitm2 
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