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ProteomicsThe HLA-Ligand-Atlas. A resource of natural HLA ligands presented on benign tissues
The human leukocyte antigen (HLA) complex regulates the adaptive immune response by showcasing the intracellular and extracellular protein content to the immune system. T cells recognize these HLA-presented peptides as self or foreign and can elicit an immune response. In this work, we describe the...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-31 | MSV000096271 | MassIVE
ProteomicsHepatocyte Deletion of Triglyceride-Synthesis Enzyme DGAT2 Reduces Steatosis without Increasing Inflammation or Fibrosis
Non-alcoholic fatty liver disease (NAFLD) is characterized by excess lipid accumulation in hepatocytes and reprepresents a huge public health problem owing to its propensity to progress to non-alcoholic steatohepatitis (NASH), fibrosis, and liver failure. The lipids stored in hepatic steatosis are p...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD013423 | Pride
Triacylglycerol Liver Diacylglycerol Nonalcoholic fatty liver disease Steatohepatitis Dietary lipids 
TranscriptomicsExpression of SUDHL-1 cell line treated by ALK inhibitors
In this study we compared the effects of ALK inhibitor on the gene expression, activation of cell signaling pathways, and functional properties of cells derived from a patient with Anaplastic Large Cell Lymphoma. we used microarrays to map the genome-wide gene expression patterns in ALK+TCL cells in...
ORGANISM(S): Homo sapiens 
2013-10-31 | E-GEOD-50803 | biostudies-arrayexpress
UnknownNPM-ALK-Induced Reprogramming of Mature TCR-Stimulated T Cells Results in Dedifferentiation and Malignant Transformation.
Not available
S-EPMC8260452 | biostudies-literature
UnknownMalignant transformation of CD4+ T lymphocytes mediated by oncogenic kinase NPM/ALK recapitulates IL-2-induced cell signaling and gene expression reprogramming.
Not available
S-EPMC3889215 | biostudies-literature
UnknownGestational weight gain during the second and third trimesters and adverse pregnancy outcomes, results from a prospective pregnancy cohort in urban Tanzania.
Not available
S-EPMC9204988 | biostudies-literature
UnknownRelationship Between Central Retinal Vessel Trunk Location and Visual Field Loss in Glaucoma.
Not available
S-EPMC5376509 | biostudies-literature
ProteomicsA Proteomic Survey of Enzymes in the Plasma and Gastric Fluid of Burmese Python
Background: Exceptional and extreme feeding behaviour makes the Burmese python (Python bivittatus) an interesting model to study physiological remodelling and metabolic adaptation in response to refeeding after prolonged starvation. In this study, we used transcriptome sequencing of five visceral o...
ORGANISM(S): Python bivittatus 
2018-10-24 | PXD006665 | Pride
Gastric fluid Burmese python Plasma Lc-ms/ms 
UnknownReversal of Glaucoma Hemifield Test Results and Visual Field Features in Glaucoma.
Not available
S-EPMC6706864 | biostudies-literature
ProteomicsSystematic genome perturbation reveals coordination of lipid droplets and metabolic gene regulation
Lipid droplets (LDs) store lipids for metabolic eneergy and are central to cellular lipid homeostasis. The mechanisms coordinating lipid storage in LDs with cellular metabolism are unclear but relevant to obesity-related diseases. Here we utilized genome-wide screening to identify genes that modulat...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD012640 | Pride
Metabolism Chrebp Mlx Mondoa Mondob Transcription facot Mlxipl Lipid droplets Glucose Mlxip 
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