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ProteomicsQuantitative Proteomics Identifies Protein Tyrosine Phosphatase 1B as Modulator of B Cell Antigen Receptor Signaling
B cell antigen receptor (BCR) signaling is initiated by protein kinases and limited by counteracting phosphatases that currently are less well studied in their regulation of BCR signaling. We here used the B cell line Ramos to identify and quantify human B cell signaling components. Specifically, a ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD024037 | Pride
Bcr signaling Ramos b cells Whole proteome analysis 
ProteomicsIdentification of novel STAT6-regulated proteins in mouse B cells by comparative transcriptome and proteome analysis
IL-4/STAT6-regulated transcriptome and proteome were compared in primary B cells isolated from wild-type and STAT6-deficient mice. B cells were purified from the spleen and stimulated in vitro with anti-CD40 and LPS or anti-IgM-F(ab)2 in the presence or absence of IL-4. Transcriptome analysis was pe...
ORGANISM(S): Mus musculus (Mouse) 
2017-03-06 | PXD005224 | Pride
Stat6 Label-free quantitative mass spectrometry B cells Il-4 
ProteomicsQuantitative Proteomics Identifies Protein Tyrosine Phosphatase 1B as Modulator of B Cell Antigen Receptor Signaling
B cell antigen receptor (BCR) signaling is initiated by protein kinases and limited by counteracting phosphatases that currently are less well studied in their regulation of BCR signaling. We here used the B cell line Ramos to identify and quantify human B cell signaling components. Specifically, a ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD024086 | Pride
Ramos b cells Ptp1b Bcr signaling Co-ip Silac Substrate trapping 
ProteomicsQuantitative Proteomics Identifies Protein Tyrosine Phosphatase 1B as Modulator of B Cell Antigen Receptor Signaling
B cell antigen receptor (BCR) signaling is initiated by protein kinases and limited by counteracting phosphatases that currently are less well studied in their regulation of BCR signaling. We here used the B cell line Ramos to identify and quantify human B cell signaling components. Specifically, a ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD024038 | Pride
Bcr signaling Ptp1b knockout Silac Ramos b cells Crispr Whole proteome analysis 
ProteomicsIdentification of TFG- and autophagy-regulated proteins and glycerophospholipids in B cells shows a role for TFG in metabolism
Autophagy supervises proteostasis and survival of plasma cells. TFG (Trk-fused gene) promotes autophagosome-lysosome flux in murine CH12 B cells, as well as their survival. Moreover, TFG is abundant in plasma cells. Hence, quantitative proteomics of CH12tfgKO and WT B cells in combination with lyso...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-27 | PXD039180 | Pride
Autophagy  autophagy flux  lysosome  b cell  endoplasmic reticulum stress  ribosome  immunoglobulin  plasma cell  jchain  trk-fused gene  phosphatidylglycerol 
ProteomicsCD22 interactome
CD22 (Siglec-2) is a member of the Siglec family. It is an inhibitory co-receptor of the B-cell-receptor (BCR) and inhibits B–cell activation. Upon BCR stimulation ITIMs in the cytoplasmic tail of CD22 are phosphorylated. This triggers CD22 signalling pathways, which lead to a decreased calcium mobi...
ORGANISM(S): Gallus gallus (Chicken) 
2020-05-06 | PXD013801 | Pride
Cullin 3 Silac B cells Cd22 Qexactive plus Dt40 cells 
ProteomicsQuantitative phosphoproteomics analysis of olfactory receptor signaling in prostate cancer cells
The olfactory receptor PSGR1 is not only expressed in olfactory tissue but shows expression in the prostate. In addition, the expression of this receptor is elevated in prostate cancer as well as other prostate diseases and can be used as diagnostic marker. The signalling cascade triggered by the ac...
ORGANISM(S): Homo sapiens (Human) 
2016-07-08 | PXD000985 | Pride
Nhe1 Prostate cancer Pyk2 Psgr1 Ionone Phosphoproteomics 
ProteomicsCharacterisation of a highly diverged putative mitochondrial ATP synthase peripheral stalk subunit b in Trypanosoma brucei
The mitochondrial F1Fo ATP synthase of Trypanosoma brucei has been studied in detail. Whereas its F1 moiety is relatively highly conserved in structure and composition, the same is not the case for the Fo part and the peripheral stalk. A core subunit of the latter, the normally conserved subunit b, ...
ORGANISM(S): Trypanosoma brucei 
2022-05-20 | PXD031259 | Pride
Silac Trypanosoma brucei Quantitative proteomics Rnai 
ProteomicsCharacterisation of a highly diverged putative mitochondrial ATP synthase peripheral stalk subunit b in Trypanosoma brucei
The mitochondrial F1Fo ATP synthase of Trypanosoma brucei has been studied in detail. Whereas its F1 moiety is relatively highly conserved in structure and composition, the same is not the case for the Fo part and the peripheral stalk. A core subunit of the latter, the normally conserved subunit b, ...
ORGANISM(S): Trypanosoma brucei 
2022-05-20 | PXD031256 | Pride
Co-immunoprecipitation Silac Trypanosoma brucei Quantitative proteomics 
ProteomicsFunctional proteomics identifies acinus L as a direct insulin- and amino acid-dependent mTORC1 substrate
The serine/threonine kinase mammalian target of rapamycin (mTOR) governs growth, metabolism, and aging in response to insulin and amino acids (aa), and is often activated in metabolic disorders and cancer. Much is known about the regulatory signaling network around mTOR, but surprisingly few direct ...
ORGANISM(S): Homo sapiens (Human) 
2015-04-28 | PXD001245 | Pride
Lc-ms Human Ms-based in vitro kinase assay Mtor 
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