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ProteomicsErythrocytes lacking the Langereis blood group protein ABCB6 are resistant to Plasmodium falciparum malaria parasites
Epstein Barr virus (EBV) replication contributes to multiple human diseases, including infectious mononucleosis, nasopharyngeal carcinoma, B-cell lymphomas, and oral hairy leukoplakia. We performed systematic quantitative analyses of temporal changes in host and EBV proteins during lytic replication...
ORGANISM(S): Homo sapiens (Human) 
2018-10-19 | PXD008752 | Pride
Human Lc-msmsms Malaria Host-pathogen interaction Quantitative proteomics Tandem mass tag 
ProteomicsADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways
Human cytomegalovirus (HCMV) is a major human pathogen whose life-long persistence is enabled by its remarkable capacity to systematically subvert host immune defences. In exploring the finding that HCMV infection upregulates tumor necrosis factor receptor 2 (TNFR2), a ligand for the proinflammatory...
ORGANISM(S): Cytomegalovirus Homo sapiens (Human) 
2023-10-11 | PXD044082 | Pride
Ul148 Tnfr2 Immune Adam17 Natural killer cell Human cytomegalovirus 
ProteomicsControl of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation
The human cytomegalovirus (HCMV) US12 family consists of ten sequentially arranged genes (US12-21) with poorly characterized function. We now identify novel NK cell evasion functions for four members: US12, US14, US18 and US20. Using a systematic multiplexed proteomics approach to quantify ~1,300 c...
ORGANISM(S): Homo sapiens (Human) Human cytomegalovirus (HHV-5) (Human herpesvirus 5) 
2017-02-14 | PXD005883 | Pride
Multiplexed proteomics Cell surface Human cytomegalovirus Natural killer 
ProteomicsHigh definition analysis of protein stability during cytomegalovirus infection informs on cellular restriction
Human cytomegalovirus (HCMV) is an important pathogen and a paradigm of viral immune evasion. Here, we describe a multiplexed approach to discover proteins with novel innate immune functions on the basis of their active proteasomal or lysosomal degradation during the early phase of HCMV infection. U...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus 
2018-08-16 | PXD009945 | Pride
Innate immunity Immune evasion Lysosome Restriction factor Host-pathogen interaction Proteasome Protein degradation Tandem mass tag Quantitative proteomics Pulsed silac 
ProteomicsHuman cytomegalovirus long non-coding RNA1.2 suppresses extracellular release of the pro-inflammatory cytokine IL-6 by blocking NF-κB activation
Long non-coding RNAs (lncRNAs) are transcripts of more than 200 nucleotides that are not translated into functional proteins. Cellular lncRNAs have been shown to act as regulators by interacting with target nucleic acids or proteins and modulating their activities. We investigated the role of RNA1.2...
ORGANISM(S): Human herpesvirus 5 strain Merlin Homo sapiens (Human) 
2020-07-08 | PXD018328 | Pride
Tprg1l Il-6 Gene regulation Nf-κb Lncrna Transcriptomics Human cytomegalovirus 
ProteomicsViral lncRNA upregulates multiple A+U-richViral lncRNA upregulates multiple A+U-rich transcripts to promote cell motility and viral dissemination transcripts to promote cell motility and viral dissemination
Long non-coding RNAs are frequently associated with broad modulation of gene expression and thus provide the cell with the ability to synchronize entire metabolic processes. We used transcriptomic and proteomic approaches to investigate whether the most abundant human cytomegalovirus-encoded lncRNA,...
ORGANISM(S): Human herpesvirus 5 strain Merlin Homo sapiens (Human) 
2021-07-27 | PXD022277 | Pride
Cell motility Gene regulation Lncrna A+u rich Transcriptomics Human cytomegalovirus Viral dissemination 
UnknownAge-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2.
Not available
S-EPMC8373615 | biostudies-literature
UnknownComplement lectin pathway activation is associated with COVID-19 disease severity, independent of MBL2 genotype subgroups.
Not available
S-EPMC10084477 | biostudies-literature
UnknownHuman Cytomegalovirus Infection of Epithelial Cells Increases SARS-CoV-2 Superinfection by Upregulating the ACE2 Receptor.
Not available
S-EPMC9927080 | biostudies-literature
UnknownSingle-cell multi-omics analysis of the immune response in COVID-19.
Not available
S-EPMC8121667 | biostudies-literature
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