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ProteomicsProtein and Signaling Pathway Responses to rhIL-6 Intervention before Lobaplatin Treatment in Osteosarcoma Cells using LC-MS/MS
Lobaplatin is a third-generation platinum-based antineoplastic agent and is widely used for osteosarcoma treatment before and after tumor removal. However, treatment failure often results from lobaplatin drug resistance. In our study, we found that SaOS-2 and SOSP-9607 osteosarcoma cells became less...
ORGANISM(S): Homo sapiens (Human) 
2021-02-25 | PXD021564 | Pride
Human Lobaplatin Rhil-6 Osteosarcoma Liquid chromatography-tandem mass spectrometry 
ProteomicsProtein and Signaling Pathway Responses to rhIL-6 Intervention before Lobaplatin Treatment in Osteosarcoma Cells using Quantitative Phosphoproteome Analysis
IL-6 plays a pivotal role in the process of drug resistance to kinds of chemotherapeutics including lobaplatin. However, the underlying changes of phosphoproteins and related signaling pathways in the posttranslational modification level is still uncover. In our study, a quantitative phosphoproteome...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025970 | Pride
Human Phosphoproteome analysis Lobaplatin Il-6 Osteosarcoma 
ProteomicsProteomics-based identification of potential therapeutic targets of artesunate in a lupus nephritis MRL/lpr mouse model
A total of 6527.0 proteins were identified in the First Affiliated Hospital of Sun Yat sen University, of which 5732.0 proteins contained quantitative information. If we take 1.5 times as the differential expression change threshold and t-test p-value < 0.05 as the significance threshold, we found t...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-24 | PXD046815 | Pride
Lupus nephritis artesunate tmt-based quantitative proteomics 
ProteomicsAnalysis of the Byssus of Chinese Green Mussel proteomics by LC-MS/MS
Here, we integrated high-throughput transcriptome and proteome sequencing to construct a comprehensive protein database for the byssus of Chinese green mussel (Perna viridis), aiming at providing novel insights into the molecular mechanisms of byssal binding to heavy metals.
ORGANISM(S): Perna viridis 
2019-04-30 | PXD009183 | Pride
Proteomics Byssus Lc-msms 
ProteomicsIdentification of a biomarker to predict doxorubicin/cisplatin chemotherapy efficacy for osteosarcoma patients by 4D data-independent acquisition (DIA) mass spectrometry with parallel reaction monitoring (PRM) verification
We analyzed the differentially expressed proteins in 37 resected tissue samples from osteosarcoma patients using paraffin- embedded specimens and 4D data-independent acquisition (DIA) quantitative mass spectrometry to investigate biomarkers for predicting the efficacy of doxorubicin/cisplatin chemot...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD051097 | Pride
Osteosarcoma  doxorubicin/cisplatin chemotherapy efficacy  data-independent acquisition (dia) mass spectrometry with parallel reaction monitoring (prm)  ctsg  neutrophil extracellular traps (nets) 
TranscriptomicsMolecular basis for chromatin binding and regulation of MLL5
The human mixed lineage leukemia 5 (MLL5) protein mediates hematopoietic cell homeostasis, cell cycle and survival, however, the molecular basis underlying MLL5 activities remains unknown. Here, we show that MLL5 is recruited to gene-rich euchromatic regions via the interaction of its PHD finger wit...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-47100 | biostudies-arrayexpress
ProteomicsData indpendent acquisition (DIA) proteomics Analysis of Tobacco Root Tip
Protein expression profiling of root tip of tobacco hybrids and parental was analyzed by data indpendent acquisition proteomics
ORGANISM(S): Nicotiana Tabacum 
PXD028624 |
ProteomicsProteomic profiling reveals the impact of surface functionalization on the protein corona formed on superparamagnetic iron oxide nanoparticles
The protein corona formed on the surface of nanomaterials is critical to understanding their biological behavior, as it is regulated by both the physicochemical properties of the nanomaterials and the physiological environment. The interplay between material synthesis characteristics, protein corona...
ORGANISM(S): Homo Sapiens 
PXD056769 |
ProteomicsPick-up single-cell proteomic analysis for quantifying up to 3000 proteins in a tumor cell
The shotgun proteomic analysis is currently the most promising single-cell protein sequencing technology, however its identification level of ~1000 proteins per cell is still insufficient for practical applications. Here, we develop a pick-up single-cell proteomic analysis (PiSPA) workflow to achiev...
ORGANISM(S): Homo Sapiens 
2023-10-30 | PXD041966 |
ProteomicsSimultaneous deep transcriptome and proteome profiling in single mouse oocytes
Deep proteome data in the single-cell multi-omics analysis of single mouse oocytes.
ORGANISM(S): Mus Musculus 
PXD043935 |
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