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TranscriptomicsWhite-to-brown metabolic conversion of human adipocytes by JAK inhibition
The rising incidence of obesity and related disorders such as diabetes and heart disease has focused considerable attention on the discovery of novel therapeutics. One promising approach has been to increase the number or activity of brown-like adipocytes in white adipose depots, as this has been...
ORGANISM(S): Homo sapiens 
2014-10-31 | E-GEOD-57896 | biostudies-arrayexpress
TranscriptomicsDysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS
The progressive loss of CNS myelin in patients with multiple sclerosis (MS) has been proposed to result from the combined effects of damage to oligodendrocytes and failure of remyelination. A common feature of demyelinated lesions is the presence of oligodendrocyte precursors (OLPs) blocked at a pre...
ORGANISM(S): Mus musculus 
2009-12-10 | E-GEOD-19403 | biostudies-arrayexpress
GenomicsEpigenome in brown and white adipose tissue
For comparative epigenomic analysis of brown fat and white fat in mice, H3K27ac and PolII ChIP-seq were performed in each depot. H3K27ac histone modification and PolII transcription profiles in mouse brown and white adipose tissues
ORGANISM(S): Mus musculus 
2015-02-10 | E-GEOD-63964 | biostudies-arrayexpress
TranscriptomicsEpigenomic profiling in visceral white adipose tissue of offspring of mice exposed to late gestational sleep fragmentation
Background: Late gestational sleep fragmentation (LG-SF) is one of the major perturbations associated with sleep apnea and other sleep disorders during pregnancy. Objectives: To investigate the effects of late LG-SF on the epigenome of visceral white adipose tissue (VWAT) in the offspring. Methods: ...
ORGANISM(S): Mus musculus 
2015-04-02 | E-GEOD-63208 | biostudies-arrayexpress
TranscriptomicsLongitudinal and Diurnal Experiments of M. hapla and M. truncatula
We have infected the model legume Medicago truncatula with Meloidogyne hapla and harvested tissue over a time course. Transcriptome sequencing was performed on each sample using the Illumina RNA-Seq method. [Longitudinal Experiment] RNA was isolated from M. hapla eggs and pre-penetration juveniles...
ORGANISM(S): root metagenome 
2017-04-30 | E-MTAB-4724 | biostudies-arrayexpress
TranscriptomicsGenetic architecture of murine skin inflammation and tumor susceptibility
Gene expression in self-renewing epithelial tissues is controlled by cis- and trans-activating regulatory factors that mediate responses to exogenous agents capable of causing tissue damage, infection, inflammation, or tumorigenesis. We used network construction methods to analyze the genetic archi...
ORGANISM(S): Mus musculus 
2008-12-31 | E-GEOD-12248 | biostudies-arrayexpress
TranscriptomicsDEPTOR cell-autonomously promotes adipogenesis and associates with obesity
An understanding of the mechanisms regulating white adipose tissue (WAT) formation is key for developing of new tools to treat obesity and its related diseases. Here, we identify DEPTOR as a positive regulator of adipogenesis whose expression is associated with obesity. In a polygenic mouse model of...
ORGANISM(S): Mus musculus 
2012-08-14 | E-GEOD-38321 | biostudies-arrayexpress
TranscriptomicsIdentification of Hipk2 as a central regulator of white fat development
Homeodomain interacting protein kinase 2 (Hipk2) has previously been implicated in control of several transcription factors involved in embryonic development, apoptosis, cell proliferation and tumour development1–3. Analysis of gene expression in tissues from genetically heterogeneous mouse or human...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-46077 | biostudies-arrayexpress
GenomicsDynamics of Genomic H3K27me3 Domains and Role of EZH2 during Pancreatic Endocrine Specification
Endoderm cells undergo a sequence of fate choices to generate insulin-secreting M-NM-2 cells. Studies of chromatin transitions during this process have been limited to the pancreatic progenitor stage that can be reconstituted from stem cells in vitro, with a gap in understanding the induction of end...
ORGANISM(S): Mus musculus 
2014-07-28 | E-GEOD-56617 | biostudies-arrayexpress
UnknownEpigenetic Profiles of Triple-Negative Breast Cancers of African American and White Females.
Not available
S-EPMC10556970 | biostudies-literature
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